From April 1996 to July 2004, an outbreak of metallo-beta-lactamase-positive (MBL) Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of VIM-2-positive strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The bla(VIM-2) gene responsible for VIM-2 MBL was not plasmid-encoded but part of a novel type of class 1 integron. VIM-2-positive strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin-tazobactam or aztreonam may be a reliable choice for treating infections with MBL-producing strains.
%0 Journal Article
%1 corvec_long-term_2008
%A Corvec, S
%A Poirel, L
%A Espaze, E
%A Giraudeau, C
%A Drugeon, H
%A Nordmann, P
%D 2008
%J The Journal of Hospital Infection
%K 80 Adult, Aged, Bacterial, Base Cross Data, Disease Drug Electrophoresis, Female, France, Gel, Hospitals, Humans, Infection, Infections Integrons, Male, Middle Molecular Multiple, Outbreaks, Phylogeny, Pseudomonas Resistance, Sequence Sequence, University, aeruginosa, and over, {Pulsed-Field,} {beta-Lactamases,}
%N 1
%P 73--82
%R 10.1016/j.jhin.2007.10.016
%T Long-term evolution of a nosocomial outbreak of Pseudomonas aeruginosa producing VIM-2 metallo-enzyme
%U http://www.ncbi.nlm.nih.gov/pubmed/18079018
%V 68
%X From April 1996 to July 2004, an outbreak of metallo-beta-lactamase-positive (MBL) Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of VIM-2-positive strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The bla(VIM-2) gene responsible for VIM-2 MBL was not plasmid-encoded but part of a novel type of class 1 integron. VIM-2-positive strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin-tazobactam or aztreonam may be a reliable choice for treating infections with MBL-producing strains.
@article{corvec_long-term_2008,
abstract = {From April 1996 to July 2004, an outbreak of metallo-beta-lactamase-positive {(MBL)} Pseudomonas aeruginosa occurred in the haematology ward at Nantes University Hospital in France. Fifty-nine patients were carriers of {VIM-2-positive} strains of whom 14 were infected (mostly urinary tract infections and pneumonia). Pulsed-field gel electrophoresis identified related isolates demonstrating resistance to all beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, rifampicin but not colistin. The {bla(VIM-2)} gene responsible for {VIM-2} {MBL} was not plasmid-encoded but part of a novel type of class 1 integron. {VIM-2-positive} strains were mostly from urine samples and clinical data suggest that in the absence of therapeutic guidelines, piperacillin-tazobactam or aztreonam may be a reliable choice for treating infections with {MBL-producing} strains.},
added-at = {2011-03-11T10:05:34.000+0100},
author = {Corvec, S and Poirel, L and Espaze, E and Giraudeau, C and Drugeon, H and Nordmann, P},
biburl = {https://www.bibsonomy.org/bibtex/2e73819f6abc5087ecb3c9d2cd19949d7/jelias},
doi = {10.1016/j.jhin.2007.10.016},
interhash = {8e1532765045f6b8d9c3d66a01e3a3d8},
intrahash = {e73819f6abc5087ecb3c9d2cd19949d7},
issn = {0195-6701},
journal = {The Journal of Hospital Infection},
keywords = {80 Adult, Aged, Bacterial, Base Cross Data, Disease Drug Electrophoresis, Female, France, Gel, Hospitals, Humans, Infection, Infections Integrons, Male, Middle Molecular Multiple, Outbreaks, Phylogeny, Pseudomonas Resistance, Sequence Sequence, University, aeruginosa, and over, {Pulsed-Field,} {beta-Lactamases,}},
month = jan,
note = {{PMID:} 18079018},
number = 1,
pages = {73--82},
timestamp = {2011-03-11T10:06:51.000+0100},
title = {Long-term evolution of a nosocomial outbreak of Pseudomonas aeruginosa producing {VIM-2} metallo-enzyme},
url = {http://www.ncbi.nlm.nih.gov/pubmed/18079018},
volume = 68,
year = 2008
}