@article{Bottcher2006dk,
title = {Computerized quantification of joint space narrowing and periarticular demineralization in patients with rheumatoid arthritis based on digital x-ray radiogrammetry.},
author = {J B{\"o}ttcher and A Pfeil and A Rosholm and P S{\"o}r{\"o}s and A Petrovitch and ML Schaefer and BE Seidl and A Malich and A Hansch and G Wolf and WA Kaiser},
journal = {Invest Radiol},
month = {Jan},
number = {1},
pages = {36-44},
volume = {41},
year = {2006},
description = {neuroscience literature},
abstract = {OBJECTIVES: The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring disease progression in patients with rheumatoid arthritis (RA). MATERIALS AND METHODS: Digital radiographs in 313 patients with varying severity of RA were performed annually and assessed by 2 radiologists using modified Larsen and also the Sharp scores within an observation period of 3 years. The hand radiographs underwent measurements of bone mineral density (BMD) and metacarpal index (MCI) by DXR, as well as computerized JSDA at the metacarpal-phalangeal articulation (JSD-MCP) for a cross-sectional and longitudinal study design. RESULTS: Both DXR-BMD (-29.6%; P < 0.01) and DXR-MCI (-31.0%; P < 0.01) revealed a notable reduction dependent on the severity of RA (from grade 1 to grade 5 of the modified Larsen score); the severity dependent decrease of mean JSD-MCP ranged from -31.9% (P < 0.01; Sharp erosion part) to -39.1% (P < 0.01) for the modified Larsen score. Over an observation period of 3 years, a significant decrease of DXR-BMD (-22.3%) and DXR-MCI (-23.3%) as well as JSD-MCP mean (-17.5%) was observed (P < 0.05), whereas an accentuated decline of DXR and JSDA parameters was verified for patients without disease-modifying antirheumatic drugs or methotrexate therapy. CONCLUSION: Computerized analysis of hand radiographs by DXR and JSDA is a promising approach to assess the severity and to monitor the progression of RA because DXR and JSDA are timely able to measure periarticular demineralization and also narrowing of JSD-MCP dependent on the severity, the medical treatment and the course of RA.},
issn = {0020-9996}, pubm = {Print}, au = {B{\"o}ttcher, J}, date-added = {2006-05-29 18:55:11 -0400}, jid = {0045377}, pmid = {16355038}, stat = {MEDLINE}, own = {NLM}, pt = {Journal Article}, so = {Invest Radiol 2006 Jan;41(1):36-44.}, pst = {ppublish}, edat = {2005/12/16 09:00}, dcom = {20060323}, date-modified = {2006-05-29 18:55:12 -0400}, da = {20051215}, language = {eng}, affiliation = {Institute of Diagnostic and Interventional Radiology; Friedrich-Schiller-University Jena, Germany. joachim.boettcher@med.uni-jena.de}, mhda = {2006/03/24 09:00},
keywords = {80 AND Adolescent Adult Aged Aged, Arthritis, Bone Demineralization, Densitometry, Disease Enhancement/*methods Female Gov't Humans Illness Image Index Joint/pathology Linear Male Metacarpophalangeal Middle Models Non-U.S. Nonparametric Pathologic/pathology Progression Radiographic Research Rheumatoid/pathology Severity Software Statistics, Support, X-Ray/*methods and neuroscience of over }
}
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