%0 Journal Article %1 budhu2008identification %A Budhu, Anuradha %A Jia, Hu-Liang %A Forgues, Marshonna %A Liu, Chang-Gong %A Goldstein, David %A Lam, Amy %A Zanetti, Krista A %A Ye, Qing-Hai %A Qin, Lun-Xiu %A Croce, Carlo M %A Tang, Zhao-You %A Wang, Xin Wei %D 2008 %J Hepatology %K 3 background cancer epigenetics mirnas %N 3 %P 897-907 %R 10.1002/hep.22160 %T Identification of metastasis-related microRNAs in hepatocellular carcinoma %U http://onlinelibrary.wiley.com/doi/10.1002/hep.22160/full %V 47 %X MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict (P < 0.001) primary HCC tissues with venous metastases from metastasis-free solitary tumors with 10-fold cross-validation. However, significant miRNAs could not be identified from the corresponding noncancerous hepatic tissues. A survival risk prediction analysis revealed that a majority of the metastasis-related miRNAs were associated with survival. Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively). These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. In addition, functional analysis of these miRNAs may enhance our biological understanding of HCC metastasis.

@article{budhu2008identification, abstract = {MicroRNAs (miRNAs) have been used as cancer-related biomarkers. Hepatocellular carcinoma (HCC) is an aggressive cancer with a dismal outcome largely due to metastasis and postsurgical recurrence. We investigated whether the expression of certain miRNAs are associated with HCC metastasis. We examined the miRNA expression profiles of 482 cancerous and noncancerous specimens from radical resection of 241 patients with HCC. Using a supervised algorithm and a clinically well-defined cohort of 131 cases, we built a unique 20-miRNA metastasis signature that could significantly predict (P < 0.001) primary HCC tissues with venous metastases from metastasis-free solitary tumors with 10-fold cross-validation. However, significant miRNAs could not be identified from the corresponding noncancerous hepatic tissues. A survival risk prediction analysis revealed that a majority of the metastasis-related miRNAs were associated with survival. Furthermore, the 20-miRNA tumor signature was validated in 110 additional cases as a significant independent predictor of survival (P = 0.009) and was significantly associated with both survival and relapse in 89 cases of early stage HCC (P = 0.022 and 0.002, respectively). These 20 miRNAs may provide a simple profiling method to assist in identifying patients with HCC who are likely to develop metastases/recurrence. In addition, functional analysis of these miRNAs may enhance our biological understanding of HCC metastasis.}, added-at = {2017-10-04T04:48:48.000+0200}, author = {Budhu, Anuradha and Jia, Hu-Liang and Forgues, Marshonna and Liu, Chang-Gong and Goldstein, David and Lam, Amy and Zanetti, Krista A and Ye, Qing-Hai and Qin, Lun-Xiu and Croce, Carlo M and Tang, Zhao-You and Wang, Xin Wei}, biburl = {https://www.bibsonomy.org/bibtex/2f3060ba3f452793b6adc77e43df1b2bc/artheibault}, description = {This article gives a list of microRNAs thought to contribute significantly to hepatocellular carcinoma. It lists miR-122 as being one of them, even though the article by Shi et al. did not determine miR-122 to be significantly dysregulated.}, doi = {10.1002/hep.22160}, interhash = {f1f8b06352802917faadc8de88827063}, intrahash = {f3060ba3f452793b6adc77e43df1b2bc}, journal = {Hepatology}, keywords = {3 background cancer epigenetics mirnas}, month = mar, number = 3, pages = {897-907}, timestamp = {2017-10-25T22:16:42.000+0200}, title = {Identification of metastasis-related microRNAs in hepatocellular carcinoma}, url = {http://onlinelibrary.wiley.com/doi/10.1002/hep.22160/full}, volume = 47, year = 2008 }