@article{joean2017suppression,
  abstract = {Because Th17-polarized airway inflammation correlates with poor control in bronchial asthma and is a feature of numerous other difficult-to-treat inflammatory lung diseases, new therapeutic approaches for this type of airway inflammation are necessary. We assessed different licensed anti-inflammatory agents with known or expected efficacy against Th17-polarization in mouse models of Th17-dependent airway inflammation. Upon intravenous transfer of in vitro derived Th17 cells and intranasal challenge with the corresponding antigen, we established acute and chronic murine models of Th17-polarised airway inflammation. Consecutively, we assessed the efficacy of methylprednisolone, roflumilast, azithromycin, AM80 and rapamycin against acute or chronic Th17-dependent airway inflammation. Quantifiers for Th17-associated inflammation comprised: bronchoalveolar lavage (BAL) differential cell counts, allergen-specific cytokine and immunoglobulin secretion, as well as flow cytometric phenotyping of pulmonary inflammatory cells. Only rapamycin proved effective against acute Th17-dependent airway inflammation, accompanied by increased plasmacytoid dendritic cells (pDCs) and reduced neutrophils as well as reduced CXCL-1 levels in BAL. Chronic Th17-dependent airway inflammation was unaltered by rapamycin treatment. None of the other agents showed efficacy in our models. Our results demonstrate that Th17-dependent airway inflammation is difficult to treat with known agents. However, we identify rapamycin as an agent with inhibitory potential against acute Th17-polarized airway inflammation.},
  added-at = {2017-11-28T10:05:53.000+0100},
  author = {Joean, O and Hueber, A and Feller, F and Jirmo, A C and Lochner, M and Dittrich, A M and Albrecht, Melanie},
  biburl = {https://www.bibsonomy.org/bibtex/2f54e5af29b87ee9b2f90b7d9452439cb/sparwasser},
  editor = {Rep, Sci},
  interhash = {30ecbfaf136d99b92fbb7eeddf611090},
  intrahash = {f54e5af29b87ee9b2f90b7d9452439cb},
  journal = {Sci Rep},
  keywords = {sparwasser},
  number = 1,
  pages = 15336,
  pubmedurl = {https://www.ncbi.nlm.nih.gov/pubmed/29127369},
  timestamp = {2017-11-28T10:05:53.000+0100},
  title = {Suppression of Th17-polarized airway inflammation by rapamycin},
  volume = 7,
  year = 2017
}