%0 Journal Article %1 Vries2004 %A Vries, Linda S De %A Haastert, Inge-Lot C Van %A Rademaker, Karin J %A Koopman, Corine %A Groenendaal, Floris %D 2004 %J J Pediatr %K Cerebral Palsy; Cerebrovascular Disorders; Echoencephalography; Humans; Infant, Newborn; Premature; Leukomalacia, Periventricular; Netherlands; Predictive Value of Tests; Prognosis; Prospective Studies; Sensitivity and Specificity %N 6 %P 815--820 %R 10.1016/j.jpeds.2004.03.034 %T Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants. %U http://dx.doi.org/10.1016/j.jpeds.2004.03.034 %V 144 %X OBJECTIVE: To assess sequential high-resolution cranial ultrasound (US) in high-risk preterm infants to predict cerebral palsy (CP). STUDY DESIGN: Preterm infants were prospectively studied (n=2139), 1636 <or=32 weeks gestational age (GA) (group A) and 503 with a GA of 33 to 36 weeks (group B). US was performed once a week until discharge and at 40 weeks postmenstrual age (PMA), using a 7.5-MHz transducer. Grade III and IV hemorrhage, cystic periventricular leukomalacia (c-PVL), and focal infarction were considered major US abnormalities. A diagnosis of CP was made at a minimum age of 24 months. RESULTS: Seventy-six (5\%) of the 1460 survivors in group A developed CP. US abnormalities were present in 70 of 76 (92\%) infants, being major in 58 (83\%) and minor in 12 (17\%). In 29\% of the CP cases with major US abnormalities, cysts were first detected beyond day 28. A further 6 infants without US abnormalities developed CP, and 3 of these infants developed ataxic CP. Twenty-nine (6\%) of the 469 survivors in group B developed CP. US abnormalities were present in 28 of 29 (96\%) infants, being major in 25 (89\%) and minor in 3 (11\%). One infant without US abnormalities developed CP. Considering the major US abnormalities, a specificity of 95\% and 99\% and a sensitivity of 76\% and 86\% were found for group A and B, respectively. The positive predictive value was 48\% in group A and 83\% in group B. CONCLUSION: Seventy-nine percent of our CP cases had major US abnormalities. To detect c-PVL, the most predictive US marker for CP, sequential scans with a 7.5-MHz transducer are required.

@article{Vries2004, abstract = {OBJECTIVE: To assess sequential high-resolution cranial ultrasound (US) in high-risk preterm infants to predict cerebral palsy (CP). STUDY DESIGN: Preterm infants were prospectively studied (n=2139), 1636 <or=32 weeks gestational age (GA) (group A) and 503 with a GA of 33 to 36 weeks (group B). US was performed once a week until discharge and at 40 weeks postmenstrual age (PMA), using a 7.5-MHz transducer. Grade III and IV hemorrhage, cystic periventricular leukomalacia (c-PVL), and focal infarction were considered major US abnormalities. A diagnosis of CP was made at a minimum age of 24 months. RESULTS: Seventy-six (5\%) of the 1460 survivors in group A developed CP. US abnormalities were present in 70 of 76 (92\%) infants, being major in 58 (83\%) and minor in 12 (17\%). In 29\% of the CP cases with major US abnormalities, cysts were first detected beyond day 28. A further 6 infants without US abnormalities developed CP, and 3 of these infants developed ataxic CP. Twenty-nine (6\%) of the 469 survivors in group B developed CP. US abnormalities were present in 28 of 29 (96\%) infants, being major in 25 (89\%) and minor in 3 (11\%). One infant without US abnormalities developed CP. Considering the major US abnormalities, a specificity of 95\% and 99\% and a sensitivity of 76\% and 86\% were found for group A and B, respectively. The positive predictive value was 48\% in group A and 83\% in group B. CONCLUSION: Seventy-nine percent of our CP cases had major US abnormalities. To detect c-PVL, the most predictive US marker for CP, sequential scans with a 7.5-MHz transducer are required.}, added-at = {2014-07-19T21:53:45.000+0200}, author = {Vries, Linda S De and Haastert, Inge-Lot C Van and Rademaker, Karin J and Koopman, Corine and Groenendaal, Floris}, biburl = {https://www.bibsonomy.org/bibtex/2fe383c1ff1cb41cb964dfd27508aef47/ar0berts}, doi = {10.1016/j.jpeds.2004.03.034}, groups = {public}, interhash = {a33c015b6aec94010933fdc42124036e}, intrahash = {fe383c1ff1cb41cb964dfd27508aef47}, journal = {J Pediatr}, keywords = {Cerebral Palsy; Cerebrovascular Disorders; Echoencephalography; Humans; Infant, Newborn; Premature; Leukomalacia, Periventricular; Netherlands; Predictive Value of Tests; Prognosis; Prospective Studies; Sensitivity and Specificity}, month = Jun, number = 6, pages = {815--820}, pii = {S0022347604002343}, pmid = {15192633}, timestamp = {2014-07-19T21:53:45.000+0200}, title = {Ultrasound abnormalities preceding cerebral palsy in high-risk preterm infants.}, url = {http://dx.doi.org/10.1016/j.jpeds.2004.03.034}, username = {ar0berts}, volume = 144, year = 2004 }