An investigation was undertaken to determine the isolation rate and antibiotic resistance of Haemophilus influenzae from the nasopharynx of young children. The 996 subjects studied were up to 6 years of age. H. influenzae was isolated from 304 (30.5\%) and strains of capsular type b from 11 (1.1\%). Age, sibling status, season, respiratory infection and antibiotic therapy all influenced isolation rates. The overall prevalence of antibiotic resistance in the strains isolated was ampicillin 5.4\% (all beta-lactamase producers), cefaclor 0.3\%, chloramphenicol 1.3\%, erythromycin 38.2\%, tetracycline 1.3\%, trimethoprim 5.4\% and sulphamethoxazole 0\%. Ampicillin resistance was more common in type b than non-capsulated strains.