%0 Journal Article %1 Lin.2005 %A Lin, J. %A Lalani, A. S. %A Harding, T. C. %A Gonzalez, M. %A Wu, W. W. %A Luan, B. %A Tu, G. H. %A Koprivnikar, K. %A VanRoey, M. J. %A He, Y. %A Alitalo, K. %A Jooss, K. %D 2005 %J Cancer Res. %K Adenoviridae Animals C Carcinoma Cell Endothelial Factor Female Gene Genetic Growth Human Humans Kidney Line Lung Lymph Lymphangiogenesis Lymphatic Male Melanoma Metastasis Mice Neoplasms Nodes Nude Prostate Prostatic Receptor-3 Renal Techniques Therapy Transfer Tumor Vascular Vectors biosynthesis blood cells genetics immunology methods pathology secondary therapy %N 15 %P 6901-6909 %T Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor %U PM:16061674 %V 65 %X The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that the lymphangiogenic growth factor, vascular endothelial growth factor-C (VEGF-C), and its receptor, VEGF receptor-3 (VEGFR3), may play a pivotal role in the promotion of metastasis to regional lymph nodes. In this study, human prostate and melanoma tumor models that preferentially metastasize to the lymph nodes following s.c. tumor cell implantation were established from lymph node metastases via in vivo selection. Melanoma tumor cell sublines established from lymph node metastasis express higher amounts of VEGF-C than the parental tumor cells. The inhibition of tumor-derived VEGF-C with a soluble VEGFR3 decoy receptor, sVEGFR3-Fc, expressed via a recombinant adeno-associated viral vector, potently blocks tumor-associated lymphangiogenesis and tumor metastasis to the lymph nodes, when the treatment was initiated before the tumor impl

@article{Lin.2005, abstract = {The presence of metastases in regional lymph nodes is a strong indicator of poor patient survival in many types of cancer. It has recently been shown that the lymphangiogenic growth factor, vascular endothelial growth factor-C (VEGF-C), and its receptor, VEGF receptor-3 (VEGFR3), may play a pivotal role in the promotion of metastasis to regional lymph nodes. In this study, human prostate and melanoma tumor models that preferentially metastasize to the lymph nodes following s.c. tumor cell implantation were established from lymph node metastases via in vivo selection. Melanoma tumor cell sublines established from lymph node metastasis express higher amounts of VEGF-C than the parental tumor cells. The inhibition of tumor-derived VEGF-C with a soluble VEGFR3 decoy receptor, sVEGFR3-Fc, expressed via a recombinant adeno-associated viral vector, potently blocks tumor-associated lymphangiogenesis and tumor metastasis to the lymph nodes, when the treatment was initiated before the tumor impl}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Lin, J. and Lalani, A. S. and Harding, T. C. and Gonzalez, M. and Wu, W. W. and Luan, B. and Tu, G. H. and Koprivnikar, K. and VanRoey, M. J. and He, Y. and Alitalo, K. and Jooss, K.}, biburl = {https://www.bibsonomy.org/bibtex/24685622165a738ccc4fae9881358cc91/kanefendt}, interhash = {3c11f368a028ff00a650cf4257393739}, intrahash = {4685622165a738ccc4fae9881358cc91}, journal = {Cancer Res.}, keywords = {Adenoviridae Animals C Carcinoma Cell Endothelial Factor Female Gene Genetic Growth Human Humans Kidney Line Lung Lymph Lymphangiogenesis Lymphatic Male Melanoma Metastasis Mice Neoplasms Nodes Nude Prostate Prostatic Receptor-3 Renal Techniques Therapy Transfer Tumor Vascular Vectors biosynthesis blood cells genetics immunology methods pathology secondary therapy}, number = 15, pages = {6901-6909}, timestamp = {2010-02-05T11:28:41.000+0100}, title = {Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor}, url = {PM:16061674}, volume = 65, year = 2005 }