%0 Journal Article %1 Marbini2002 %A Marbini, Adriana %A Ferrari, A. %A Cioni, G. %A Bellanova, M. F. %A Fusco, C. %A Gemignani, F. %D 2002 %J Brain Dev %K Adolescent; Biopsy; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Immunohistochemistry; Male; Muscle Fibers, Fast-Twitch; Slow-Twitch; Spasticity; Muscle, Skeletal; Muscular Atrophy; Neural Cell Adhesion Molecules %N 2 %P 63--66 %T Immunohistochemical study of muscle biopsy in children with cerebral palsy. %V 24 %X Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.

@article{Marbini2002, abstract = {Muscle biopsy was examined in 20 children with cerebral palsy, using immunohistochemical methods for marker of denervation neural cell adhesion molecules (N-CAM) in addition to standard techniques. Histological and histochemical study showed mild myopathic changes, type 1 predominance, and type 1 and type 2 hypotrophy, in accord with previous observations. Immunohistochemical study showed N-CAM expression in most biopsies (15/20), usually in scattered fibers, whereas in four patients aged less than 6 years it was expressed in grouped fibers. Our study supports the hypothesis of motor unit remodeling as a consequence of spasticity, especially in early phases of the disease.}, added-at = {2014-07-19T20:45:36.000+0200}, author = {Marbini, Adriana and Ferrari, A. and Cioni, G. and Bellanova, M. F. and Fusco, C. and Gemignani, F.}, biburl = {https://www.bibsonomy.org/bibtex/2bf7dcd70209e7cb8d5da1c40d0f94f9a/ar0berts}, groups = {public}, interhash = {41140a671704a86d0d41e221bfec60ca}, intrahash = {bf7dcd70209e7cb8d5da1c40d0f94f9a}, journal = {Brain Dev}, keywords = {Adolescent; Biopsy; Cerebral Palsy; Child; Child, Preschool; Female; Humans; Immunohistochemistry; Male; Muscle Fibers, Fast-Twitch; Slow-Twitch; Spasticity; Muscle, Skeletal; Muscular Atrophy; Neural Cell Adhesion Molecules}, month = Mar, number = 2, pages = {63--66}, pii = {S0387760401003941}, pmid = {11891093}, timestamp = {2014-07-19T20:45:36.000+0200}, title = {Immunohistochemical study of muscle biopsy in children with cerebral palsy.}, username = {ar0berts}, volume = 24, year = 2002 }