Article,

Characterization of Extended-Spectrum Beta-Lactamases and qnr Plasmid-Mediated Quinolone Resistance in German Isolates of Enterobacter Species

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Microbial Drug Resistance (Larchmont, N.Y.), 17 (1): 99--103 (March 2011)PMID: 21190474.
DOI: 10.1089/mdr.2010.0114

Abstract

The objective of this study was to characterize the antimicrobial resistance patterns of 100 clinical isolates of Enterobacter spp. with special regard to the occurrence of extended-spectrum beta-lactamases (ESBLs) and plasmid-mediated quinolone resistance by qnr-determinants. The rate of ESBL- and qnr-positive isolates was 7\% and 14\%, respectively. Thirteen isolates harbored a qnrA1, and a further isolate harbored a qnrB4 gene. Moreover, qnr-determinants were significantly associated with ESBL-expression. No carbapeneme or tigecycline resistance was detected in the collective tested. To conclude, these data confirm the increase of multiple antimicrobial resistance mechanisms in Enterobacter spp.

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