Abstract
Connections between perturbations that lie outside of our genome,
that is, epigenetic alternations, and tumorigenesis have become increasingly
apparent. Dynamic chromatin remodeling of the fundamental nucleosomal
structure (covered in this review) or the covalent marks residing
in the histone proteins that make up this structure (covered previously
in part I) underlie many fundamental cellular processes, including
transcriptional regulation and DNA-damage repair. Dysregulation of
these processes has been linked to cancer development. Mechanisms
of chromatin remodeling include dynamic interplay between ATP-dependent
complexes, covalent histone modifications, utilization of histone
variants and DNA methylation. In part II of this series, we focus
on connections between ATP-dependent chromatin-remodeling complexes
and oncogenesis and discuss the potential clinical implications of
chromatin remodeling and cancer.
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