%0 Journal Article %1 v5061587 %A Ersing, Ina %A Bernhardt, Katharina %A Gewurz, Benjamin E. %D 2013 %J Viruses %K myown %N 6 %P 1587 %R 10.3390/v5061587 %T NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1 %U http://www.mdpi.com/1999-4915/5/6/1587 %V 5 %X The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.

@article{v5061587, abstract = {The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.}, added-at = {2016-11-19T02:52:16.000+0100}, author = {Ersing, Ina and Bernhardt, Katharina and Gewurz, Benjamin E.}, biburl = {https://www.bibsonomy.org/bibtex/24d8430d61aeb07b9be86c3949fc5ccfc/bgewurz}, doi = {10.3390/v5061587}, interhash = {51ff8f9a296fa72db1e158902ebdd7fe}, intrahash = {4d8430d61aeb07b9be86c3949fc5ccfc}, issn = {1999-4915}, journal = {Viruses}, keywords = {myown}, number = 6, pages = 1587, pubmedid = {23793113}, timestamp = {2016-11-19T02:52:16.000+0100}, title = {NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1}, url = {http://www.mdpi.com/1999-4915/5/6/1587}, volume = 5, year = 2013 }