%0 Journal Article %1 Allington2005 %A Allington, Nanni %A Vivegnis, Danielle %A Gerard, Paul %D 2005 %J Acta Orthop Belg %K Adolescent; Anti-Inflammatory Agents; Cerebral Palsy; Child; Child, Preschool; Diphosphonates; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Neuromuscular Diseases; Osteoporosis; Pain; Prospective Studies; Treatment Outcome %N 1 %P 91--97 %T Cyclic administration of pamidronate to treat osteoporosis in children with cerebral palsy or a neuromuscular disorder: a clinical study. %V 71 %X Eighteen osteoporotic (Z-score at or below 2.5) nonambulatory children with cerebral palsy or a neuromuscular disorder received cyclic intravenous administration of pamidronate. One year after treatment, bone densitometry showed an improvement in all patients: a mean increase of 13\% +/- 15\% standard deviation (SD) (p < 10(-5)) on the global data, and a mean increase of 27\% +/- 15\% (p < 10(-5)) on the most significant area for each individual patient. Clinical improvement was found in all patients, with a decrease in pain on manipulation, and no new fractures. No major adverse effects were reported. Cyclic intravenous administration of pamidronate is a useful tool in the treatment of osteoporosis in these children.

@article{Allington2005, abstract = {Eighteen osteoporotic (Z-score at or below 2.5) nonambulatory children with cerebral palsy or a neuromuscular disorder received cyclic intravenous administration of pamidronate. One year after treatment, bone densitometry showed an improvement in all patients: a mean increase of 13\% +/- 15\% standard deviation (SD) (p < 10(-5)) on the global data, and a mean increase of 27\% +/- 15\% (p < 10(-5)) on the most significant area for each individual patient. Clinical improvement was found in all patients, with a decrease in pain on manipulation, and no new fractures. No major adverse effects were reported. Cyclic intravenous administration of pamidronate is a useful tool in the treatment of osteoporosis in these children.}, added-at = {2014-07-19T17:38:16.000+0200}, author = {Allington, Nanni and Vivegnis, Danielle and Gerard, Paul}, biburl = {https://www.bibsonomy.org/bibtex/2e72991c111a1c8c86251eeb8ac115a20/ar0berts}, groups = {public}, interhash = {598e131263ea44a5a376c9538564a6c7}, intrahash = {e72991c111a1c8c86251eeb8ac115a20}, journal = {Acta Orthop Belg}, keywords = {Adolescent; Anti-Inflammatory Agents; Cerebral Palsy; Child; Child, Preschool; Diphosphonates; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Neuromuscular Diseases; Osteoporosis; Pain; Prospective Studies; Treatment Outcome}, month = Feb, number = 1, pages = {91--97}, pmid = {15792214}, timestamp = {2014-07-19T17:38:16.000+0200}, title = {Cyclic administration of pamidronate to treat osteoporosis in children with cerebral palsy or a neuromuscular disorder: a clinical study.}, username = {ar0berts}, volume = 71, year = 2005 }