%0 Journal Article %1 Abbasoglu.Theeffectofhemeoxygenase1inductionbyoctreotideonradiationenteritis %A Abbasoglu, S. D. %A Erbil, Y. %A Eren, T. %A Giris, M. %A Barbaros, U. %A Yucel, R. %A Olgac, V. %A Uysal, M. %A Toker, G. %D 2006 %J Peptides %K abdomen Animals apoptosis caspase Caspase_3 Caspases Enteritis Gastrointestinal Gastrointestinal_Agents Heme_Oxygenase-1 ileum inflammation intestinal intestine irradiation Male Malondialdehyde metabolism myeloperoxidase Octreotide pathology Peroxidase pharmacology radiation Radiation_Injuries Experimental rat Rats Wistar Small_intestine %P 1570--1576 %T The effect of heme oxygenase-1 induction by octreotide on radiation enteritis %V 27 %X Radiation enteritis occurs as a response to abdominal radiation, which can cause mucosal damage in the gastrointestinal mucosal epithelium. The small intestine is one of the most radiosensitive organs in the abdomen. The present study was undertaken to investigate the effect of octreotide (OCT) administration on heme oxygenase-1 (HO-1) expression of the radiation enteritis model. Rats received 50 mg/kg/day OCT for 4 days before irradiation and continued for 3 days after irradiation. Intestinal myeloperoxidase (MPO) activities, malondialdehyde (MDA) levels are indicators of oxidative damage while caspase-3 activities reveal apoptosis degree of the small intestine. At histological examination, the terminal ileum tissue was analyzed for morphological changes. Irradiation significantly increased the intestinal MPO and caspase-3 activities, MDA levels and HO-1 expression in comparison to sham control group. OCT treatment was associated with increased HO-1 expression and caspase-3 activity, decreased MPO activity and MDA levels. Histological examination revealed that the intestinal mucosal structure was preserved in the OCT treated group. OCT appears to have protective effects against radiation-induced intestinal damage. This protective effect is, in part, mediated by modification of the inflammatory response and the induction of HO-1 expression

@article{Abbasoglu.Theeffectofhemeoxygenase1inductionbyoctreotideonradiationenteritis, abstract = {Radiation enteritis occurs as a response to abdominal radiation, which can cause mucosal damage in the gastrointestinal mucosal epithelium. The small intestine is one of the most radiosensitive organs in the abdomen. The present study was undertaken to investigate the effect of octreotide (OCT) administration on heme oxygenase-1 (HO-1) expression of the radiation enteritis model. Rats received 50 mg/kg/day OCT for 4 days before irradiation and continued for 3 days after irradiation. Intestinal myeloperoxidase (MPO) activities, malondialdehyde (MDA) levels are indicators of oxidative damage while caspase-3 activities reveal apoptosis degree of the small intestine. At histological examination, the terminal ileum tissue was analyzed for morphological changes. Irradiation significantly increased the intestinal MPO and caspase-3 activities, MDA levels and HO-1 expression in comparison to sham control group. OCT treatment was associated with increased HO-1 expression and caspase-3 activity, decreased MPO activity and MDA levels. Histological examination revealed that the intestinal mucosal structure was preserved in the OCT treated group. OCT appears to have protective effects against radiation-induced intestinal damage. This protective effect is, in part, mediated by modification of the inflammatory response and the induction of HO-1 expression}, added-at = {2013-01-07T08:04:08.000+0100}, author = {Abbasoglu, S. D. and Erbil, Y. and Eren, T. and Giris, M. and Barbaros, U. and Yucel, R. and Olgac, V. and Uysal, M. and Toker, G.}, biburl = {https://www.bibsonomy.org/bibtex/267829e1b12179c81865e31a1b2b2d390/citavitest}, interhash = {5a1dfd282252a9b8e7bbd4bb32745336}, intrahash = {67829e1b12179c81865e31a1b2b2d390}, journal = {Peptides}, keywords = {abdomen Animals apoptosis caspase Caspase_3 Caspases Enteritis Gastrointestinal Gastrointestinal_Agents Heme_Oxygenase-1 ileum inflammation intestinal intestine irradiation Male Malondialdehyde metabolism myeloperoxidase Octreotide pathology Peroxidase pharmacology radiation Radiation_Injuries Experimental rat Rats Wistar Small_intestine}, pages = {1570--1576}, timestamp = {2013-01-07T08:04:08.000+0100}, title = {The effect of heme oxygenase-1 induction by octreotide on radiation enteritis}, volume = 27, year = 2006 }