%0 Journal Article %1 Purz.2011 %A Purz, Sandra %A Mauz-Körholz, Christine %A Körholz, Dieter %A Hasenclever, Dirk %A Krausse, Antje %A Sorge, Ina %A Ruschke, Kathrin %A Stiefel, Martina %A Amthauer, Holger %A Schober, Otmar %A Kranert, W. Tilman %A Weber, Wolfgang A. %A Haberkorn, Uwe %A Hundsdörfer, Patrick %A Ehlert, Karoline %A Becker, Martina %A Rössler, Jochen %A Kulozik, Andreas E. %A Sabri, Osama %A Kluge, Regine %D 2011 %J Journal of clinical oncology : official journal of the American Society of Clinical Oncology %K Adolescent Biopsy Bone_Marrow_Neoplasms/pathology/radionuclide_imaging/secondary Child Female Fluorodeoxyglucose_F18/diagnostic_use Hodgkin_Disease/pathology/radionuclide_imaging Humans Male Neoplasm_Staging Prospective_Studies Radiopharmaceuticals/diagnostic_use Sensitivity_and_Specificity %N 26 %P 3523–3528 %T 18FFluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin's lymphoma %V 29 %X PURPOSE\r\nCurrently, a routine bone marrow biopsy (BMB) is performed to detect bone marrow (BM) involvement in pediatric Hodgkin's lymphoma (HL) stage greater than IIA. (18)Ffluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used for the initial staging of HL. The value of using FDG-PET to detect BM involvement has not been sufficiently defined. We compared the results of BMBs and FDG-PET for the diagnosis of BM involvement in a large pediatric group with HL.\r\nPATIENTS AND METHODS\r\nThe initial staging of 175 pediatric patients with newly diagnosed classical HL stage greater than IIA was determined by using BMB, FDG-PET, chest computed tomography (CT), and magnetic resonance imaging (MRI) or CT of the neck, abdomen, and pelvis. Staging images were prospectively evaluated by a central review board. Skeletal regions that were suggestive of BM involvement by either method were re-evaluated by using different imaging modalities. In suspicious cases, bone scintigraphy was performed. If follow-up FDG-PET scans were available, the remission of skeletal lesions during treatment was evaluated.\r\nRESULTS\r\nBMB results were positive in seven of 175 patients and were identified by FDG-PET. FDG-PET scans showed BM involvement in 45 patients. In addition, the lesions of 32 of these 45 patients had a typical multifocal pattern. In 38 of 39 follow-up positron emission tomography scans, most of the skeletal lesions disappeared after chemotherapy. There was no patient with skeletal findings suggestive of BM involvement by MRI or CT with a negative FDG-PET.\r\nCONCLUSION\r\nFDG-PET is a sensitive and specific method for the detection of BM involvement in pediatric HL. The sensitivity of a BMB appears compromised by the focal pattern of BM involvement. Thus, FDG-PET may safely be substituted for a BMB in routine staging procedures.

@article{Purz.2011, abstract = {PURPOSE\r\nCurrently, a routine bone marrow biopsy (BMB) is performed to detect bone marrow (BM) involvement in pediatric Hodgkin's lymphoma (HL) stage greater than IIA. [(18)F]fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used for the initial staging of HL. The value of using FDG-PET to detect BM involvement has not been sufficiently defined. We compared the results of BMBs and FDG-PET for the diagnosis of BM involvement in a large pediatric group with HL.\r\nPATIENTS AND METHODS\r\nThe initial staging of 175 pediatric patients with newly diagnosed classical HL stage greater than IIA was determined by using BMB, FDG-PET, chest computed tomography (CT), and magnetic resonance imaging (MRI) or CT of the neck, abdomen, and pelvis. Staging images were prospectively evaluated by a central review board. Skeletal regions that were suggestive of BM involvement by either method were re-evaluated by using different imaging modalities. In suspicious cases, bone scintigraphy was performed. If follow-up FDG-PET scans were available, the remission of skeletal lesions during treatment was evaluated.\r\nRESULTS\r\nBMB results were positive in seven of 175 patients and were identified by FDG-PET. FDG-PET scans showed BM involvement in 45 patients. In addition, the lesions of 32 of these 45 patients had a typical multifocal pattern. In 38 of 39 follow-up positron emission tomography scans, most of the skeletal lesions disappeared after chemotherapy. There was no patient with skeletal findings suggestive of BM involvement by MRI or CT with a negative FDG-PET.\r\nCONCLUSION\r\nFDG-PET is a sensitive and specific method for the detection of BM involvement in pediatric HL. The sensitivity of a BMB appears compromised by the focal pattern of BM involvement. Thus, FDG-PET may safely be substituted for a BMB in routine staging procedures.}, added-at = {2014-10-14T15:28:09.000+0200}, author = {Purz, Sandra and Mauz-Körholz, Christine and Körholz, Dieter and Hasenclever, Dirk and Krausse, Antje and Sorge, Ina and Ruschke, Kathrin and Stiefel, Martina and Amthauer, Holger and Schober, Otmar and Kranert, W. Tilman and Weber, Wolfgang A. and Haberkorn, Uwe and Hundsdörfer, Patrick and Ehlert, Karoline and Becker, Martina and Rössler, Jochen and Kulozik, Andreas E. and Sabri, Osama and Kluge, Regine}, biburl = {https://www.bibsonomy.org/bibtex/283a8cda254ca1674e56313f1e97246b7/drtester}, interhash = {5ca51ffaa11a370e4ab6598081822dd6}, intrahash = {83a8cda254ca1674e56313f1e97246b7}, journal = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology}, keywords = {Adolescent Biopsy Bone_Marrow_Neoplasms/pathology/radionuclide_imaging/secondary Child Female Fluorodeoxyglucose_F18/diagnostic_use Hodgkin_Disease/pathology/radionuclide_imaging Humans Male Neoplasm_Staging Prospective_Studies Radiopharmaceuticals/diagnostic_use Sensitivity_and_Specificity}, number = 26, pages = {3523–3528}, timestamp = {2014-10-14T15:28:09.000+0200}, title = {[18F]Fluorodeoxyglucose positron emission tomography for detection of bone marrow involvement in children and adolescents with Hodgkin's lymphoma}, volume = 29, year = 2011 }