%0 Journal Article %1 Jackson:2008:Int-J-Epidemiol:18381388 %A Jackson, C %A Best, N %A Elliott, P %D 2008 %J Int J Epidemiol %K Biobank UK chemistry clinical cohort epidemiology haematology studies %P 16-22 %R 10.1093/ije/dym280 %T UK Biobank Pilot Study: stability of haematological and clinical chemistry analytes %U http://www.ncbi.nlm.nih.gov/pubmed/?term=UK+Biobank+Pilot+Study%3A+Stability+of+haematological+and+clinical+chemistry+analytes %V 37 Suppl 1 %X Analytes in blood and urine may vary over time according to conditions of transport and storage.UK Biobank pilot study to investigate stability through time of 42 haematological and clinical chemistry analytes in blood and four analytes in urine, kept in storage for up to 36 h, for 40 individuals. Random effects linear regressions were used to model the change through time in repeated assay results on a sample, allowing for heterogeneity between individuals and assay variability.Assay results for most analytes tended to show a small negative bias (1-3% per 12 h stored) over time on average. Statistically significant (P 0.9. Results for freeze-thaw samples were not materially different from those for non-freeze-thaw samples, except that stability of the analyte results was only assessed up to 12 h.The results suggest that any instability in assay results up to 36 h is likely to be small in comparison with between individual differences and assay error, and that a single assay measurement at any time between 0 and 36 h should give a representative value of the analyte concentration at time zero for that individual.

@article{Jackson:2008:Int-J-Epidemiol:18381388, abstract = {Analytes in blood and urine may vary over time according to conditions of transport and storage.UK Biobank pilot study to investigate stability through time of 42 haematological and clinical chemistry analytes in blood and four analytes in urine, kept in storage for up to 36 h, for 40 individuals. Random effects linear regressions were used to model the change through time in repeated assay results on a sample, allowing for heterogeneity between individuals and assay variability.Assay results for most analytes tended to show a small negative bias (1-3% per 12 h stored) over time on average. Statistically significant (P 0.9. Results for freeze-thaw samples were not materially different from those for non-freeze-thaw samples, except that stability of the analyte results was only assessed up to 12 h.The results suggest that any instability in assay results up to 36 h is likely to be small in comparison with between individual differences and assay error, and that a single assay measurement at any time between 0 and 36 h should give a representative value of the analyte concentration at time zero for that individual.}, added-at = {2013-08-30T15:46:59.000+0200}, author = {Jackson, C and Best, N and Elliott, P}, biburl = {https://www.bibsonomy.org/bibtex/2d68e3fe88b404c24e5c6b4f2b7578f60/joerg.geiger}, description = {UK Biobank Pilot Study: stability of haemato... [Int J Epidemiol. 2008] - PubMed - NCBI}, doi = {10.1093/ije/dym280}, interhash = {5f921297398d98c99386e5fca4697175}, intrahash = {d68e3fe88b404c24e5c6b4f2b7578f60}, journal = {Int J Epidemiol}, keywords = {Biobank UK chemistry clinical cohort epidemiology haematology studies}, month = apr, pages = {16-22}, pmid = {18381388}, timestamp = {2013-08-30T15:46:59.000+0200}, title = {UK Biobank Pilot Study: stability of haematological and clinical chemistry analytes}, url = {http://www.ncbi.nlm.nih.gov/pubmed/?term=UK+Biobank+Pilot+Study%3A+Stability+of+haematological+and+clinical+chemistry+analytes}, volume = {37 Suppl 1}, year = 2008 }