Abstract
How the brain perceives sensory information and generates
meaningful behavior depends critically on its underlying
circuitry. The protocerebral bridge (PB) is a major part of
the insect central complex (CX), a premotor center that may
be analogous to the human basal ganglia. Here, by
deconstructing hundreds of PB single neurons and
reconstructing them into a common three-dimensional framework,
we have constructed a comprehensive map of PB circuits with
labeled polarity and predicted directions of information
flow. Our analysis reveals a highly ordered information
processing system that involves directed information flow
among CX subunits through 194 distinct PB neuron
types. Circuitry properties such as mirroring, convergence,
divergence, tiling, reverberation, and parallel signal
propagation were observed; their functional and evolutional
significance is discussed. This layout of PB neuronal
circuitry may provide guidelines for further investigations on
transformation of sensory (e.g., visual) input into locomotor
commands in fly brains.
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