%0 Journal Article %1 Meier1989 %A Meier, F. %A Gross, E. %A Klotz, K. N. %A Ruzicka, T. %D 1989 %J Skin Pharmacol %K 80 Adolescent Adult Aged Aged, Atopic/*metabolism B4 B4/*metabolism Binding Child Dermatitis, Female Humans Immunologic/*metabolism Kinetics Leukotriene Male Middle Neutrophils/*metabolism Protein Psoriasis/*metabolism and over Receptor %N 2 %P 61-7 %T Leukotriene B4 receptors on neutrophils in patients with psoriasis and atopic eczema %U http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2560652 %V 2 %X Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. Elevated concentrations of the chemoattractant eicosanoid leukotriene B4 (LTB4) are present in psoriatic skin. Its chemotactic activity is mediated via high affinity receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the LTB4 receptor density or affinity (or both). No significant difference was found between patients with psoriasis, healthy controls and patients with another inflammatory dermatosis (atopic eczema) with regard to the binding parameters of LTB4 receptors on PMNL. Our findings suggest that PMNL accumulation in psoriatic skin may be the result of an excess of cutaneous chemoattractant rather than the increased readiness of psoriatic PMNL to migrate towards LTB4 due to altered LTB4 receptor density or affinity.

@article{Meier1989, abstract = {Polymorphonuclear leukocyte (PMNL) infiltration is an important characteristic in psoriatic lesions. Elevated concentrations of the chemoattractant eicosanoid leukotriene B4 (LTB4) are present in psoriatic skin. Its chemotactic activity is mediated via high affinity receptors on PMNL. The goal of our work was to ascertain whether PMNL infiltration in psoriasis can be accounted for by functional abnormalities of the circulating PMNL due to alterations in the LTB4 receptor density or affinity (or both). No significant difference was found between patients with psoriasis, healthy controls and patients with another inflammatory dermatosis (atopic eczema) with regard to the binding parameters of LTB4 receptors on PMNL. Our findings suggest that PMNL accumulation in psoriatic skin may be the result of an excess of cutaneous chemoattractant rather than the increased readiness of psoriatic PMNL to migrate towards LTB4 due to altered LTB4 receptor density or affinity.}, added-at = {2010-12-14T18:12:02.000+0100}, author = {Meier, F. and Gross, E. and Klotz, K. N. and Ruzicka, T.}, biburl = {https://www.bibsonomy.org/bibtex/271e47e2ff3e2025bb62c3df12a11c574/pharmawuerz}, endnotereftype = {Journal Article}, interhash = {7cbc4f4914ec7f5aef464301445264e9}, intrahash = {71e47e2ff3e2025bb62c3df12a11c574}, issn = {1011-0283 (Print) 1011-0283 (Linking)}, journal = {Skin Pharmacol}, keywords = {80 Adolescent Adult Aged Aged, Atopic/*metabolism B4 B4/*metabolism Binding Child Dermatitis, Female Humans Immunologic/*metabolism Kinetics Leukotriene Male Middle Neutrophils/*metabolism Protein Psoriasis/*metabolism and over Receptor}, note = {Meier, F Gross, E Klotz, K N Ruzicka, T Comparative Study Research Support, Non-U.S. Gov't Switzerland Skin pharmacology : the official journal of the Skin Pharmacology Society Skin Pharmacol. 1989;2(2):61-7.}, number = 2, pages = {61-7}, shorttitle = {Leukotriene B4 receptors on neutrophils in patients with psoriasis and atopic eczema}, timestamp = {2010-12-14T18:20:07.000+0100}, title = {Leukotriene B4 receptors on neutrophils in patients with psoriasis and atopic eczema}, url = {http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=2560652}, volume = 2, year = 1989 }