%0 Journal Article %1 noauthororeditor %A Otito1, Chinedu Imo1* Friday O. Uhegbu1 Ifeanacho Nkeiruka G.2 Egbeigwe %A S.3, Ezekwe A. %D 2014 %J International Journal of Biomolecules and Biomedicine (IJBB) %K Acetaminophen Gongronema biochemical changes histological latifolium %N No. 2 %P p. 1-7 %T Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats %U http://dx.doi.org/10.6084/m9.figshare.1406892 %V Vol. 4 %X This study examined the biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the G. latifolium leaf extract seems to be dose dependent on the liver enzymes and protein concentration measured. The results showed that acetaminophen-induced hepatic toxicity in the wistar albino rats as observed in the negative control was reversed with the administration of the leaf extract of Gongronema latifolium (in groups 3, 4 and 5) in the test animals. The histological analysis of the liver showed that the extract had a normalising effect on the effected liver. These results indicate that the leaf extract of Gongronema latifolium exhibits biochemical and histological changes and can be used against some hepatic inflammations.

@article{noauthororeditor, abstract = {This study examined the biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymes ALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the G. latifolium leaf extract seems to be dose dependent on the liver enzymes and protein concentration measured. The results showed that acetaminophen-induced hepatic toxicity in the wistar albino rats as observed in the negative control was reversed with the administration of the leaf extract of Gongronema latifolium (in groups 3, 4 and 5) in the test animals. The histological analysis of the liver showed that the extract had a normalising effect on the effected liver. These results indicate that the leaf extract of Gongronema latifolium exhibits biochemical and histological changes and can be used against some hepatic inflammations.}, added-at = {2015-05-07T08:39:29.000+0200}, author = {Otito1, Chinedu Imo1* Friday O. Uhegbu1 Ifeanacho Nkeiruka G.2 Egbeigwe and S.3, Ezekwe A.}, biburl = {https://www.bibsonomy.org/bibtex/216603eb4748a60e524737de2009c1d89/rajzahid}, interhash = {8349326f507b3251f6a00c39a9e28e2f}, intrahash = {16603eb4748a60e524737de2009c1d89}, journal = {International Journal of Biomolecules and Biomedicine (IJBB)}, keywords = {Acetaminophen Gongronema biochemical changes histological latifolium}, location = {,, http: / / dx. doi}, month = {02}, note = {org / 10. 6084 / m 9. figshare. 1406892}, number = {No. 2}, pages = {p. 1-7}, timestamp = {2015-05-07T08:39:29.000+0200}, title = {Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats}, url = {http://dx.doi.org/10.6084/m9.figshare.1406892}, volume = {Vol. 4}, year = 2014 }