%0 Journal Article %1 Marx_1998_818 %A Marx, S. O. %A Ondrias, K. %A Marks, A. R. %D 1998 %J Science %K 9714684 Animals, Bilayers, Binding Calcium Calcium, Carrier Cell Channel Channel, Channels, DNA-Binding Gating, Gov't, Heat-Shock Immunoph, Ion Isomerase, Line, Lipid Macromolecular Membrane Muscle, Non-U.S. P.H.S., Peptidylprolyl Polyenes, Potentials, Probability, Proteins, Rabbits, Receptor Recombinant Release Research Reticulum, Ryanodine Ryanodine, Sarcoplasmic Sirolimus, Skeletal, Spodoptera, Substances, Support, Tacrolimus Transfection, U.S. ilins, %N 5378 %P 818--821 %T Coupled gating between individual skeletal muscle Ca$^2+$ release channels (ryanodine receptors) %U http://www.sciencemag.org/cgi/content/full/281/5378/818 %V 281 %X Excitation-contraction coupling in skeletal muscle requires the release of intracellular calcium ions (Ca$^2+$) through ryanodine receptor (RyR1) channels in the sarcoplasmic reticulum. Half of the RyR1 channels are activated by voltage-dependent Ca$^2+$ channels in the plasma membrane. In planar lipid bilayers, RyR1 channels exhibited simultaneous openings and closings, termed "coupled gating." Addition of the channel accessory protein FKBP12 induced coupled gating, and removal of FKBP12 uncoupled channels. Coupled gating provides a mechanism by which RyR1 channels that are not associated with voltage-dependent Ca$^2+$ channels can be regulated.

@article{Marx_1998_818, abstract = {Excitation-contraction coupling in skeletal muscle requires the release of intracellular calcium ions ({C}a$^{2+}$) through ryanodine receptor (RyR1) channels in the sarcoplasmic reticulum. Half of the RyR1 channels are activated by voltage-dependent {C}a$^{2+}$ channels in the plasma membrane. In planar lipid bilayers, RyR1 channels exhibited simultaneous openings and closings, termed "coupled gating." Addition of the channel accessory protein {FKBP}12 induced coupled gating, and removal of {FKBP}12 uncoupled channels. Coupled gating provides a mechanism by which RyR1 channels that are not associated with voltage-dependent {C}a$^{2+}$ channels can be regulated.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Marx, S. O. and Ondrias, K. and Marks, A. R.}, biburl = {https://www.bibsonomy.org/bibtex/287bcc9328fe2f0e0dbf9fffa0723165b/hake}, description = {The whole bibliography file I use.}, file = {Marx_1998_818.pdf:Marx_1998_818.pdf:PDF}, interhash = {8b20700cff4509f4a417a17a46ccfd08}, intrahash = {87bcc9328fe2f0e0dbf9fffa0723165b}, journal = {Science}, keywords = {9714684 Animals, Bilayers, Binding Calcium Calcium, Carrier Cell Channel Channel, Channels, DNA-Binding Gating, Gov't, Heat-Shock Immunoph, Ion Isomerase, Line, Lipid Macromolecular Membrane Muscle, Non-U.S. P.H.S., Peptidylprolyl Polyenes, Potentials, Probability, Proteins, Rabbits, Receptor Recombinant Release Research Reticulum, Ryanodine Ryanodine, Sarcoplasmic Sirolimus, Skeletal, Spodoptera, Substances, Support, Tacrolimus Transfection, U.S. ilins,}, month = Aug, number = 5378, pages = {818--821}, pmid = {9714684}, timestamp = {2009-06-03T11:21:22.000+0200}, title = {Coupled gating between individual skeletal muscle {C}a$^{2+}$ release channels (ryanodine receptors)}, url = {http://www.sciencemag.org/cgi/content/full/281/5378/818}, volume = 281, year = 1998 }