%0 Journal Article %1 Cai1999 %A Cai, W. %A Gayen, S. K. %A Xu, M. %A Zevallos, M. %A Alrubaiee, M. %A Lax, M. %A Alfano, R. R. %B Applied Optics %D 1999 %J Applied Optics %K 2009 Image Inverse Medical Time-resolved Turbid and biological imaging media mps mps2009 problems reconstruction techniques %P 4237-4246-- %T Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements %U http://ao.osa.org/abstract.cfm?URI=ao-38-19-4237 %V 38 %X Optical imaging and localization of objects inside a highly scattering medium, such as a tumor in the breast, is a challenging problem with many practical applications. Conventional imaging methods generally provide only two-dimensional (2-D) images of limited spatial resolution with little diagnostic ability. Here we present an inversion algorithm that uses time-resolved transillumination measurements in the form of a sequence of picosecond-duration intensity patterns of transmitted ultrashort light pulses to reconstruct three-dimensional (3-D) images of an absorbing object located inside a slab of a highly scattering medium. The experimental arrangement used a 3-mm-diameter collimated beam of 800-nm, 150-fs, 1-kHz repetition rate light pulses from a Ti:sapphire laser and amplifier system to illuminate one side of the slab sample. An ultrafast gated intensified camera system that provides a minimum FWHM gate width of 80 ps recorded the 2-D intensity patterns of the light transmitted through the opposite side of the slab. The gate position was varied in steps of 100 ps over a 5-ns range to obtain a sequence of 2-D transmitted. light intensity patterns of both less-scattered and multiple-scattered light for image reconstruction. The inversion algorithm is based on the diffusion approximation of the radiative transfer theory for photon transport in a turbid medium. It uses a Green's function perturbative approach under the Rytov approximation and combines a 2-D matrix inversion with a one-dimensional Fourier-transform inversion to achieve speedy 3-D image reconstruction. In addition to the lateral position, the method provides information about the axial position of the object as well, whereas the 2-D reconstruction methods yield only lateral position. (C) 1999 Optical Society of America.

@article{Cai1999, abstract = {Optical imaging and localization of objects inside a highly scattering medium, such as a tumor in the breast, is a challenging problem with many practical applications. Conventional imaging methods generally provide only two-dimensional (2-D) images of limited spatial resolution with little diagnostic ability. Here we present an inversion algorithm that uses time-resolved transillumination measurements in the form of a sequence of picosecond-duration intensity patterns of transmitted ultrashort light pulses to reconstruct three-dimensional (3-D) images of an absorbing object located inside a slab of a highly scattering medium. The experimental arrangement used a 3-mm-diameter collimated beam of 800-nm, 150-fs, 1-kHz repetition rate light pulses from a Ti:sapphire laser and amplifier system to illuminate one side of the slab sample. An ultrafast gated intensified camera system that provides a minimum FWHM gate width of 80 ps recorded the 2-D intensity patterns of the light transmitted through the opposite side of the slab. The gate position was varied in steps of 100 ps over a 5-ns range to obtain a sequence of 2-D transmitted. light intensity patterns of both less-scattered and multiple-scattered light for image reconstruction. The inversion algorithm is based on the diffusion approximation of the radiative transfer theory for photon transport in a turbid medium. It uses a Green's function perturbative approach under the Rytov approximation and combines a 2-D matrix inversion with a one-dimensional Fourier-transform inversion to achieve speedy 3-D image reconstruction. In addition to the lateral position, the method provides information about the axial position of the object as well, whereas the 2-D reconstruction methods yield only lateral position. (C) 1999 Optical Society of America.}, added-at = {2009-11-19T14:40:48.000+0100}, author = {Cai, W. and Gayen, S. K. and Xu, M. and Zevallos, M. and Alrubaiee, M. and Lax, M. and Alfano, R. R.}, biburl = {https://www.bibsonomy.org/bibtex/2025cb18b546bcb2fabf94d5ee6483fee/photonics}, booktitle = {Applied Optics}, interhash = {9622f400609c635b9c1e3c64703a0c03}, intrahash = {025cb18b546bcb2fabf94d5ee6483fee}, journal = {Applied Optics}, keywords = {2009 Image Inverse Medical Time-resolved Turbid and biological imaging media mps mps2009 problems reconstruction techniques}, owner = {gianluca}, pages = {4237-4246--}, refid = {456}, timestamp = {2009-11-19T14:40:52.000+0100}, title = {Optical tomographic image reconstruction from ultrafast time-sliced transmission measurements}, url = {http://ao.osa.org/abstract.cfm?URI=ao-38-19-4237}, volume = 38, year = 1999 }