%0 Journal Article %1 Taudorf1989 %A Taudorf, K. %A Vorstrup, S. %D 1989 %J Neuropediatrics %K Adolescent; Adult; Blood Flow Velocity; Cerebral Palsy; Cerebrovascular Circulation; Child; Female; Humans; Image Processing, Computer-Assisted; Infant, Newborn; Premature; Male; Tomography, X-Ray Computed %N 1 %P 33--40 %T Cerebral blood flow abnormalities in cerebral palsied children with a normal CT scan. %V 20 %X Cerebral palsy (CP) is often a consequence of a hypoxic-ischemic encephalopathy and/or intracerebral hemorrhage secondary to pre- and peri-natal asphyxia. Hypodense lesions on the CT-scan are found in about 70 to 80\% of CP-patients. In the present study, regional cerebral blood flow (CBF) was measured in CP-patients having a normal CT-scan. The aim was to correlate the CBF changes with the clinical and the etiologic findings. CBF was measured by xenon-133 inhalation and single photon emission computer tomography. The mean CBF value in 20 CP-patients, age 6-19 years, was 67 +/- 11 (1 SD) ml/100g/min, the same value as found in the 9 normal children. However, 16 of the 20 CP-patients had focal hypoperfused areas on the tomographic flow map. In the preterm infants (n = 7) the hypoperfused areas were mainly located in the posterior watershed areas, often in one hemisphere only. In the term infants (n = 13) both asymmetrical and symmetrical hypoperfused areas were observed in the anterior and posterior watershed areas. In addition, several children had larger low flow areas in the frontal and fronto-parietal lobes. In both groups, a relatively poor concordance was observed between the clinical findings and the expected location of the low flow area.

@article{Taudorf1989, abstract = {Cerebral palsy (CP) is often a consequence of a hypoxic-ischemic encephalopathy and/or intracerebral hemorrhage secondary to pre- and peri-natal asphyxia. Hypodense lesions on the CT-scan are found in about 70 to 80\% of CP-patients. In the present study, regional cerebral blood flow (CBF) was measured in CP-patients having a normal CT-scan. The aim was to correlate the CBF changes with the clinical and the etiologic findings. CBF was measured by xenon-133 inhalation and single photon emission computer tomography. The mean CBF value in 20 CP-patients, age 6-19 years, was 67 +/- 11 (1 SD) ml/100g/min, the same value as found in the 9 normal children. However, 16 of the 20 CP-patients had focal hypoperfused areas on the tomographic flow map. In the preterm infants (n = 7) the hypoperfused areas were mainly located in the posterior watershed areas, often in one hemisphere only. In the term infants (n = 13) both asymmetrical and symmetrical hypoperfused areas were observed in the anterior and posterior watershed areas. In addition, several children had larger low flow areas in the frontal and fronto-parietal lobes. In both groups, a relatively poor concordance was observed between the clinical findings and the expected location of the low flow area.}, added-at = {2014-07-19T21:42:33.000+0200}, author = {Taudorf, K. and Vorstrup, S.}, biburl = {https://www.bibsonomy.org/bibtex/29375109b36aaeb4c1313ed12438e30eb/ar0berts}, groups = {public}, interhash = {a4d3d886b8345295faaf2bcf516e3ee8}, intrahash = {9375109b36aaeb4c1313ed12438e30eb}, journal = {Neuropediatrics}, keywords = {Adolescent; Adult; Blood Flow Velocity; Cerebral Palsy; Cerebrovascular Circulation; Child; Female; Humans; Image Processing, Computer-Assisted; Infant, Newborn; Premature; Male; Tomography, X-Ray Computed}, month = Feb, number = 1, pages = {33--40}, pmid = {2716964}, timestamp = {2014-07-19T21:45:47.000+0200}, title = {Cerebral blood flow abnormalities in cerebral palsied children with a normal CT scan.}, username = {ar0berts}, volume = 20, year = 1989 }