%0 Journal Article %1 taber-per %A Taber, LA %A Perucchio, R %C SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS %D 2000 %I KLUWER ACADEMIC PUBL %J JOURNAL OF ELASTICITY %K heart muscle %N 1-3 %P 165-197 %R 10.1023/A:1011082712497 %T Modeling heart development %V 61 %X Mechanics plays a major role in heart development. This paper reviews some of the mechanical aspects involved in theoretical modeling of the embryonic heart as it transforms from a single tube into a four-chambered pump. In particular, large deformations and significant alterations in structure lead to highly nonlinear boundary value problems. First, the biological background for the problem is discussed. Next, a modified elasticity theory is presented that includes active contraction and growth, and the theory is incorporated into a finite element analysis. Finally, models for the heart are presented to illustrate the developmental processes of growth, remodeling, and morphogenesis. Combining such models with appropriate experiments should shed light on the complex mechanisms involved in cardiac development.

@article{taber-per, abstract = {{Mechanics plays a major role in heart development. This paper reviews some of the mechanical aspects involved in theoretical modeling of the embryonic heart as it transforms from a single tube into a four-chambered pump. In particular, large deformations and significant alterations in structure lead to highly nonlinear boundary value problems. First, the biological background for the problem is discussed. Next, a modified elasticity theory is presented that includes active contraction and growth, and the theory is incorporated into a finite element analysis. Finally, models for the heart are presented to illustrate the developmental processes of growth, remodeling, and morphogenesis. Combining such models with appropriate experiments should shed light on the complex mechanisms involved in cardiac development.}}, added-at = {2013-01-07T13:42:10.000+0100}, address = {{SPUIBOULEVARD 50, PO BOX 17, 3300 AA DORDRECHT, NETHERLANDS}}, affiliation = {{Taber, LA (Reprint Author), Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA.. Washington Univ, Dept Biomed Engn, St Louis, MO 63130 USA. Univ Rochester, Dept Mech Engn, Rochester, NY 14627 USA.}}, author = {Taber, LA and Perucchio, R}, biburl = {https://www.bibsonomy.org/bibtex/2ef9a7527c994f2d3ba17d6ad22105523/jehiorns}, doc-delivery-number = {{450KK}}, doi = {{10.1023/A:1011082712497}}, interhash = {af4ba41af4a8f15afa63c13800aaca67}, intrahash = {ef9a7527c994f2d3ba17d6ad22105523}, issn = {{0374-3535}}, journal = {{JOURNAL OF ELASTICITY}}, journal-iso = {{J. Elast.}}, keywords = {heart muscle}, keywords-plus = {{EMBRYONIC CHICK HEART; RAT LEFT-VENTRICLE; CARDIAC-HYPERTROPHY; RESIDUAL STRAIN; GROWTH; STRESS; MORPHOGENESIS; ADAPTATION; MECHANICS; PRESSURE}}, language = {{English}}, number = {{1-3}}, number-of-cited-references = {{66}}, pages = {{165-197}}, publisher = {{KLUWER ACADEMIC PUBL}}, research-areas = {{Engineering; Materials Science; Mechanics}}, times-cited = {{39}}, timestamp = {2013-01-07T13:42:10.000+0100}, title = {{Modeling heart development}}, type = {{Article}}, unique-id = {{ISI:000169741700008}}, volume = {{61}}, web-of-science-categories = {{Engineering, Multidisciplinary; Materials Science, Multidisciplinary; Mechanics}}, year = {{2000}} }