%0 Journal Article %1 10.1371/journal.ppat.1006345 %A Popovic, B %A Golemac, M %A Podlech, J %A Zeleznjak, J %A Bilic-Zulle, L %A Lukic, M L %A Cicin-Sain, L %A Reddehase, M J %A Sparwasser, T %A Krmpotic, A %A Jonjic, S %D 2017 %I Public Library of Science %J PLoS Pathog %K sparwasser %N 4 %P 1-23 %T IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection %V 13 %X Author summary Treg cells are crucial for immune homeostasis and for dampening immune response to several diseased conditions, including viral infections. Murine cytomegalovirus (MCMV) is a herpesvirus with pathogenic potential, so that early immune mechanisms are essential in controlling virus and protecting from virus-induced pathology. Studies on Foxp3+ Treg cells have revealed their inhibitory role on the early T cell response to MCMV infection and have suggested Treg cells as a target of MCMV’s immunoevasion mechanisms. Here we demonstrate that the number and activation status of liver Treg cells is strongly induced upon MCMV infection in order to protect the host from severe liver damage. They constitutively express high amounts of IL-33 receptor ST2 and their accumulation depends on IL-33, which is released as a tissue alarmin after the cell damage. For the first time, we show an immunoregulatory role of IL-33-dependent Treg cells in the liver of MCMV infected mice and their suppression of MCMV-induced immunopathology.

@article{10.1371/journal.ppat.1006345, abstract = {Author summary Treg cells are crucial for immune homeostasis and for dampening immune response to several diseased conditions, including viral infections. Murine cytomegalovirus (MCMV) is a herpesvirus with pathogenic potential, so that early immune mechanisms are essential in controlling virus and protecting from virus-induced pathology. Studies on Foxp3+ Treg cells have revealed their inhibitory role on the early T cell response to MCMV infection and have suggested Treg cells as a target of MCMV’s immunoevasion mechanisms. Here we demonstrate that the number and activation status of liver Treg cells is strongly induced upon MCMV infection in order to protect the host from severe liver damage. They constitutively express high amounts of IL-33 receptor ST2 and their accumulation depends on IL-33, which is released as a tissue alarmin after the cell damage. For the first time, we show an immunoregulatory role of IL-33-dependent Treg cells in the liver of MCMV infected mice and their suppression of MCMV-induced immunopathology.}, added-at = {2017-04-28T12:17:40.000+0200}, author = {Popovic, B and Golemac, M and Podlech, J and Zeleznjak, J and Bilic-Zulle, L and Lukic, M L and Cicin-Sain, L and Reddehase, M J and Sparwasser, T and Krmpotic, A and Jonjic, S}, biburl = {https://www.bibsonomy.org/bibtex/2015c447d1484dcb2892d60b0ef11ac9f/sparwasser}, interhash = {bba754716092c5601a061ff825dfc770}, intrahash = {015c447d1484dcb2892d60b0ef11ac9f}, journal = {PLoS Pathog}, keywords = {sparwasser}, month = {04}, number = 4, pages = {1-23}, publisher = {Public Library of Science}, pubmedurl = {10.1371/journal.ppat.1006345}, timestamp = {2017-04-28T12:17:40.000+0200}, title = {IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection}, volume = 13, year = 2017 }