%0 Journal Article %1 Hu2002 %A Hu, Y. %A Grainger, D. W. %A Winn, S. R. %A Hollinger, J. O. %D 2002 %J J Biomed Mater Res %K *Absorbable ; Acid/chemical Adhesion/drug Bone Cell Culture Electron, Engineering/*methods Gov't, Humans Implants Lactic Line Microscopy, Molecular Osteoblasts/cytology/drug P.H.S. Polyesters/chemical Polyglycolic Polymers/chemical Porosity Research Scanning Solvents/chemistry Substitutes/*chemical Support, Techniques Tissue U.S. Weight effects synthesis/chemistry/*pharmacology synthesis/chemistry/pharmacology %N 3 %P 563-72 %T Fabrication of poly(alpha-hydroxy acid) foam scaffolds using multiple solvent systems. %U http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?cmd=prlinks&dbfrom=pubmed&retmode=ref&id=11774315 %V 59 %X The present studies describe the fabrication and characterization of highly porous and interconnected poly(alpha-hydroxy acid) foam scaffolds produced using a phase separation multisolvent system, followed by a sublimation process. Fabrication parameters, including solvent composition, polymer concentration, freezing temperature, polymer type, and polymer molecular weight, were optimized to produce the desired foam microstructure. Analyses of selected samples with scanning electron microscopic images and mercury intrusion porosimetry indicated polymer foams with pore size ranges of 100-350 microm, a porosity >90%, and an interconnecting open-pore foam structure. Scaffold degradation profiles varied according to the type and molecular weight of the polymers. Cytocompatibility assays demonstrated that the preferred foam structures were nontoxic and osteoprecursor cells seeded into the scaffolds exhibited the ability to attach, propagate, and differentiate into a calcified structure.

@article{Hu2002, __markedentry = {[phpts:6]}, abstract = {The present studies describe the fabrication and characterization of highly porous and interconnected poly(alpha-hydroxy acid) foam scaffolds produced using a phase separation multisolvent system, followed by a sublimation process. Fabrication parameters, including solvent composition, polymer concentration, freezing temperature, polymer type, and polymer molecular weight, were optimized to produce the desired foam microstructure. Analyses of selected samples with scanning electron microscopic images and mercury intrusion porosimetry indicated polymer foams with pore size ranges of 100-350 microm, a porosity >90%, and an interconnecting open-pore foam structure. Scaffold degradation profiles varied according to the type and molecular weight of the polymers. Cytocompatibility assays demonstrated that the preferred foam structures were nontoxic and osteoprecursor cells seeded into the scaffolds exhibited the ability to attach, propagate, and differentiate into a calcified structure.}, added-at = {2011-11-04T13:47:04.000+0100}, author = {Hu, Y. and Grainger, D. W. and Winn, S. R. and Hollinger, J. O.}, authoraddress = {Bone Tissue Engineering Center, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA.}, biburl = {https://www.bibsonomy.org/bibtex/20fd93788d9b5a516a8d81941b31e56fb/pawelsikorski}, interhash = {c007bfef10a1de783a872d2e0f590950}, intrahash = {0fd93788d9b5a516a8d81941b31e56fb}, journal = {J Biomed Mater Res}, keywords = {*Absorbable ; Acid/chemical Adhesion/drug Bone Cell Culture Electron, Engineering/*methods Gov't, Humans Implants Lactic Line Microscopy, Molecular Osteoblasts/cytology/drug P.H.S. Polyesters/chemical Polyglycolic Polymers/chemical Porosity Research Scanning Solvents/chemistry Substitutes/*chemical Support, Techniques Tissue U.S. Weight effects synthesis/chemistry/*pharmacology synthesis/chemistry/pharmacology}, language = {eng}, medline-aid = {10.1002/jbm.1269 [pii]}, medline-ci = {Copyright 2001 John Wiley & Sons, Inc.}, medline-da = {20020104}, medline-dcom = {20030425}, medline-edat = {2002/01/05 10:00}, medline-fau = {Hu, Yunhua ; Grainger, David W ; Winn, Shelley R ; Hollinger, Jeffrey O}, medline-gr = {R01-DE11416-03/DE/NIDCR ; R01-DE13018-01/DE/NIDCR}, medline-is = {0021-9304 (Print)}, medline-jid = {0112726}, medline-jt = {Journal of biomedical materials research.}, medline-lr = {20041117}, medline-mhda = {2003/04/26 05:00}, medline-own = {NLM}, medline-pl = {United States}, medline-pmid = {11774315}, medline-pst = {ppublish}, medline-pt = {Journal Article}, medline-pubm = {Print}, medline-rn = {0 (Bone Substitutes) ; 0 (Polyesters) ; 0 (Polymers) ; 0 (Solvents) ; 0 (polylactic acid-polyglycolic acid copolymer) ; 26009-03-0 (Polyglycolic Acid) ; 26969-66-4 (poly(lactide)) ; 50-21-5 (Lactic Acid)}, medline-sb = {IM}, medline-so = {J Biomed Mater Res. 2002 Mar 5;59(3):563-72.}, medline-stat = {MEDLINE}, number = 3, owner = {phpts}, pages = {563-72}, timestamp = {2011-11-04T13:47:13.000+0100}, title = {Fabrication of poly(alpha-hydroxy acid) foam scaffolds using multiple solvent systems.}, url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?cmd=prlinks\&dbfrom=pubmed\&retmode=ref\&id=11774315}, volume = 59, year = 2002 }