%0 Journal Article %1 platonov_long_2003 %A Platonov, Alexander E %A Vershinina, Irina V %A Kuijper, Edward J %A Borrow, Ray %A Käyhty, Helena %D 2003 %J Vaccine %K A, Adult, Antibodies, Bacterial, Chain Complement Female, G, Humans, Immunization, Immunoglobulin Kinetics, Lipopolysaccharides, M, Male, Meningitis, Meningococcal Meningococcal, Polymerase Proteins, Reaction, Reverse Secondary, Serotyping, Studies, System Transcriptase Vaccination Vaccines, {Follow-Up} %N 27-30 %P 4437--4447 %T Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine %U http://www.ncbi.nlm.nih.gov/pubmed/14505927 %V 21 %X Of 45 Russian patients with late complement component deficiency (LCCD) who experienced one to five meningococcal infections, 31 were immunised with a meningococcal A/C/W135/Y polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin (Ig) class specific concentration of antibodies to meningococcal polysaccharides in sera of LCCD patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of LCCD patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated LCCD persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees (P\textless0.05). Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in LCCD patients.

@article{platonov_long_2003, abstract = {Of 45 Russian patients with late complement component deficiency {(LCCD)} who experienced one to five meningococcal infections, 31 were immunised with a meningococcal {A/C/W135/Y} polysaccharide vaccine and were followed for 3-8 years. Total and immunoglobulin {(Ig)} class specific concentration of antibodies to meningococcal polysaccharides in sera of {LCCD} patients increased significantly 1 month after vaccination and remained elevated for 3 years. Revaccination of {LCCD} patients 3 years after the first dose restored the total Ig concentrations to those observed 1 year after the first vaccination. Six new episodes of meningococcal infection in four patients developed in the group of 31 vaccinees; six episodes in six patients developed in the same time in the group of 14 non-vaccinated {LCCD} persons. Survival analysis demonstrated the risk to contract meningococcal disease decreased significantly for vaccinees in comparison to non-vaccinees {(P{\textless}0.05).} Vaccination with of meningococcal tetravalent polysaccharide vaccine decreases the risk of meningococcal infection in {LCCD} patients.}, added-at = {2011-03-11T10:05:34.000+0100}, author = {Platonov, Alexander E and Vershinina, Irina V and Kuijper, Edward J and Borrow, Ray and Käyhty, Helena}, biburl = {https://www.bibsonomy.org/bibtex/29c677ce3866336150b9d689349014d07/jelias}, interhash = {c6d09bfddbc4d68da31ebce423aa78f9}, intrahash = {9c677ce3866336150b9d689349014d07}, issn = {{0264-410X}}, journal = {Vaccine}, keywords = {A, Adult, Antibodies, Bacterial, Chain Complement Female, G, Humans, Immunization, Immunoglobulin Kinetics, Lipopolysaccharides, M, Male, Meningitis, Meningococcal Meningococcal, Polymerase Proteins, Reaction, Reverse Secondary, Serotyping, Studies, System Transcriptase Vaccination Vaccines, {Follow-Up}}, month = oct, note = {{PMID:} 14505927}, number = {27-30}, pages = {4437--4447}, timestamp = {2011-03-11T10:06:14.000+0100}, title = {Long term effects of vaccination of patients deficient in a late complement component with a tetravalent meningococcal polysaccharide vaccine}, url = {http://www.ncbi.nlm.nih.gov/pubmed/14505927}, volume = 21, year = 2003 }