%0 Journal Article %1 RN10 %A Khodaie-Ardakani, Mohammad-Reza %A Mirshafiee, Omid %A Farokhnia, Mehdi %A Tajdini, Masih %A Hosseini, Seyed-Mohammad-Reza %A Modabbernia, Amirhossein %A Rezaei, Farzin %A Salehi, Bahman %A Yekehtaz, Habibeh %A Ashrafi, Mandana %A Tabrizi, Mina %A Akhondzadeh, Shahin %D 2014 %J Psychiatry Research %K imported public %N 3 %P 540-546 %R 10.1016/j.psychres.2013.12.051 %T Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Randomized double-blind placebo-controlled study %V 215 %X The objective of this study was to assess the efficacy and tolerability of minocycline add-on to risperidone in treatment of negative symptoms of patients with chronic schizophrenia. In a randomized double-blind placebo-controlled study, 40 patients with chronic schizophrenia who were stabilized on risperidone for a minimum duration of eight weeks were recruited. The patients were randomly assigned to minocycline (titrated up to 200mg/day) or placebo in addition to risperidone (maximum dose of 6mg/day) for eight weeks. Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale, and Extrapyramidal Syndrome Rating Scale were used. Thirty-eight patients completed the study. Significant time×treatment interaction for negative F(2.254,85.638)=59.046, P<0.001 general psychopathology F(1.703,64.700)=6.819, P=0.001, and positive subscales F(1.655,62.878)=5.193, P=0.012 as well as total PANSS scores F(1.677,63.720)=28.420, P<0.001 were observed. The strongest predictors for change in negative symptoms were the treatment group (β=−0.94, t=−10.59, P<0.001) followed by the change in PANSS positive subscale (β=−0.185, t=−2.075, P=0.045). Side effect profiles of the two treatment regimens were not significantly different. Minocycline seems to be an efficacious and tolerable short-term add-on to risperidone for treatment of negative and general psychopathology symptoms of schizophrenia.

@article{RN10, abstract = {The objective of this study was to assess the efficacy and tolerability of minocycline add-on to risperidone in treatment of negative symptoms of patients with chronic schizophrenia. In a randomized double-blind placebo-controlled study, 40 patients with chronic schizophrenia who were stabilized on risperidone for a minimum duration of eight weeks were recruited. The patients were randomly assigned to minocycline (titrated up to 200mg/day) or placebo in addition to risperidone (maximum dose of 6mg/day) for eight weeks. Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale, and Extrapyramidal Syndrome Rating Scale were used. Thirty-eight patients completed the study. Significant time×treatment interaction for negative [F(2.254,85.638)=59.046, P<0.001] general psychopathology [F(1.703,64.700)=6.819, P=0.001], and positive subscales [F(1.655,62.878)=5.193, P=0.012] as well as total PANSS scores [F(1.677,63.720)=28.420, P<0.001] were observed. The strongest predictors for change in negative symptoms were the treatment group (β=−0.94, t=−10.59, P<0.001) followed by the change in PANSS positive subscale (β=−0.185, t=−2.075, P=0.045). Side effect profiles of the two treatment regimens were not significantly different. Minocycline seems to be an efficacious and tolerable short-term add-on to risperidone for treatment of negative and general psychopathology symptoms of schizophrenia.}, added-at = {2017-10-14T21:46:53.000+0200}, author = {Khodaie-Ardakani, Mohammad-Reza and Mirshafiee, Omid and Farokhnia, Mehdi and Tajdini, Masih and Hosseini, Seyed-Mohammad-Reza and Modabbernia, Amirhossein and Rezaei, Farzin and Salehi, Bahman and Yekehtaz, Habibeh and Ashrafi, Mandana and Tabrizi, Mina and Akhondzadeh, Shahin}, biburl = {https://www.bibsonomy.org/bibtex/2e685192fa7ab82c4cb7a24ef52204d5b/tngominh}, doi = {10.1016/j.psychres.2013.12.051}, interhash = {c868b8acdd495eb23644d6fa853b92db}, intrahash = {e685192fa7ab82c4cb7a24ef52204d5b}, issn = {0165-1781}, journal = {Psychiatry Research}, keywords = {imported public}, number = 3, pages = {540-546}, timestamp = {2017-10-15T05:59:08.000+0200}, title = {Minocycline add-on to risperidone for treatment of negative symptoms in patients with stable schizophrenia: Randomized double-blind placebo-controlled study}, type = {Journal Article}, volume = 215, year = 2014 }