%0 Journal Article %1 Chen.20070215 %A Chen, I. Emily %A Hewel, Johannes %A Krueger, S. Joseph %A Tiraby, Claire %A Weber, R. Martin %A Kralli, Anastasia %A Becker, Katja %A Yates, R. John %A Felding-Habermann, Brunhilde %D 2007/02/15/ %J Cancer Res %K Animal Animals Brain_Neoplasms Breast_Neoplasms Cell_Growth_Processes Citric_Acid_Cycle Disease_Models Energy_Metabolism Female Glutathione Glycolysis Humans IFZ Mice Mitochondria Oxidation-Reduction Oxygen_Consumption Pentose_Phosphate_Pathway Proteomics SCID %N 4 %P 1472-1486 %T Adaptation of energy metabolism in breast cancer brain metastases %V 67 %X Brain metastases are among the most feared complications in breast cancer, as no therapy exists that prevents or eliminates breast cancer spreading to the brain. New therapeutic strategies depend on specific knowledge of tumor cell properties that allow breast cancer cell growth within the brain tissue. To provide information in this direction, we established a human breast cancer cell model for brain metastasis based on circulating tumor cells from a breast cancer patient and variants of these cells derived from bone or brain lesions in immunodeficient mice. The brain-derived cells showed an increased potential for brain metastasis in vivo and exhibited a unique protein expression profile identified by large-scale proteomic analysis. This protein profile is consistent with either a selection of predisposed cells or bioenergetic adaptation of the tumor cells to the unique energy metabolism of the brain. Increased expression of enzymes involved in glycolysis, tricarboxylic acid cycle, a

@article{Chen.20070215, abstract = {Brain metastases are among the most feared complications in breast cancer, as no therapy exists that prevents or eliminates breast cancer spreading to the brain. New therapeutic strategies depend on specific knowledge of tumor cell properties that allow breast cancer cell growth within the brain tissue. To provide information in this direction, we established a human breast cancer cell model for brain metastasis based on circulating tumor cells from a breast cancer patient and variants of these cells derived from bone or brain lesions in immunodeficient mice. The brain-derived cells showed an increased potential for brain metastasis in vivo and exhibited a unique protein expression profile identified by large-scale proteomic analysis. This protein profile is consistent with either a selection of predisposed cells or bioenergetic adaptation of the tumor cells to the unique energy metabolism of the brain. Increased expression of enzymes involved in glycolysis, tricarboxylic acid cycle, a}, added-at = {2008-10-14T16:07:18.000+0200}, author = {Chen, I. Emily and Hewel, Johannes and Krueger, S. Joseph and Tiraby, Claire and Weber, R. Martin and Kralli, Anastasia and Becker, Katja and Yates, R. John and Felding-Habermann, Brunhilde}, biburl = {https://www.bibsonomy.org/bibtex/2b1ec0fa05f47269651b25ab8ed7eaad5/nutribiochem}, interhash = {fabd294c85a1d5e39799c33cf6d40d98}, intrahash = {b1ec0fa05f47269651b25ab8ed7eaad5}, journal = {Cancer Res}, keywords = {Animal Animals Brain_Neoplasms Breast_Neoplasms Cell_Growth_Processes Citric_Acid_Cycle Disease_Models Energy_Metabolism Female Glutathione Glycolysis Humans IFZ Mice Mitochondria Oxidation-Reduction Oxygen_Consumption Pentose_Phosphate_Pathway Proteomics SCID}, number = 4, pages = {1472-1486}, timestamp = {2008-10-14T16:08:42.000+0200}, title = {Adaptation of energy metabolism in breast cancer brain metastases}, volume = 67, year = {2007/02/15/} }