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Westergren&lt;/a&gt; &lt;/span&gt;&lt;em&gt;ECIS, &lt;/em&gt;&lt;em&gt;page 1179-1189. &lt;/em&gt;&lt;em&gt;University of St. Gallen, &lt;/em&gt;(&lt;em&gt;2007&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/2e454b1f1a7822caa1be97fc60c6f10b2/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/2e454b1f1a7822caa1be97fc60c6f10b2/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#InProceedings"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/conf/ecis/ecis2007.html#Westergren07"/><swrc:date>Wed Nov 23 00:00:00 CET 2011</swrc:date><swrc:booktitle>ECIS</swrc:booktitle><swrc:crossref>conf/ecis/2007</swrc:crossref><swrc:pages>1179-1189</swrc:pages><swrc:publisher><swrc:Organization swrc:name="University of St. Gallen"/></swrc:publisher><swrc:title>Partnership Outsourcing Evolution - The Process of Creating and Maintaining a Network of Actors.</swrc:title><swrc:year>2007</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://is2.lse.ac.uk/asp/aspecis/20070181.pdf" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika H. 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&lt;/span&gt;&lt;em&gt;ECIS, &lt;/em&gt;&lt;em&gt;page 1691-1702. &lt;/em&gt;(&lt;em&gt;2006&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/2e580cb600269f8ec2c969d045b621f7e/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/2e580cb600269f8ec2c969d045b621f7e/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#InProceedings"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/conf/ecis/ecis2006.html#Josefsson06"/><swrc:date>Wed Nov 23 00:00:00 CET 2011</swrc:date><swrc:booktitle>ECIS</swrc:booktitle><swrc:crossref>conf/ecis/2006</swrc:crossref><swrc:pages>1691-1702</swrc:pages><swrc:title>Exploring e-patients  heterogeneity: towards personalized e-health applications.</swrc:title><swrc:year>2006</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://is2.lse.ac.uk/asp/aspecis/20060146.pdf" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Josefsson"/></rdf:_1></rdf:Seq></swrc:author><swrc:editor><rdf:Seq><rdf:_1><swrc:Person swrc:name="Jan Ljungberg"/></rdf:_1><rdf:_2><swrc:Person swrc:name="Magnus Andersson"/></rdf:_2></rdf:Seq></swrc:editor></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/24793d9024e5403d84bdf5884fe9d631d/dblp"><title>Towards a New design Metaphor: Supporting Boundary Objects as means of knowledge sharing in Community Networks.</title><link>http://www.bibsonomy.org/bibtex/24793d9024e5403d84bdf5884fe9d631d/dblp</link><dc:creator>dblp</dc:creator><dc:date>2011-11-23T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Snis&#034;&gt;Ulrika Lundh Snis&lt;/a&gt;, &lt;a href=&#034;/author/Bernheim&#034;&gt;Bo-Göran Bernheim&lt;/a&gt;,  and &lt;a href=&#034;/author/Hattinger&#034;&gt;Monika Hattinger&lt;/a&gt; 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&lt;/span&gt;&lt;em&gt;ECIS, &lt;/em&gt;&lt;em&gt;page 783-793. &lt;/em&gt;(&lt;em&gt;2002&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/206b4fa6f0e3860811e6d534a10c11ef0/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/206b4fa6f0e3860811e6d534a10c11ef0/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#InProceedings"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/conf/ecis/ecis2002.html#Snis02"/><swrc:date>Wed Nov 23 00:00:00 CET 2011</swrc:date><swrc:booktitle>ECIS</swrc:booktitle><swrc:crossref>conf/ecis/2002</swrc:crossref><swrc:pages>783-793</swrc:pages><swrc:title>Challenges For Knowledge Communities In Technical Work Domains.</swrc:title><swrc:year>2002</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://is2.lse.ac.uk/asp/aspecis/20020146.pdf" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Lundh Snis"/></rdf:_1></rdf:Seq></swrc:author><swrc:editor><rdf:Seq><rdf:_1><swrc:Person swrc:name="Stanislaw Wrycza"/></rdf:_1></rdf:Seq></swrc:editor></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/242f02f01f4af7f3b0e7e541a3edd16e6/dblp"><title>Panel: Different approaches to evaluation of information systems.</title><link>http://www.bibsonomy.org/bibtex/242f02f01f4af7f3b0e7e541a3edd16e6/dblp</link><dc:creator>dblp</dc:creator><dc:date>2011-11-23T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Snis&#034;&gt;Ulrika Lundh Snis&lt;/a&gt;, &lt;a href=&#034;/author/Eriksson&#034;&gt;Owen Eriksson&lt;/a&gt;, &lt;a href=&#034;/author/Grundén&#034;&gt;Kerstin Grundén&lt;/a&gt;, &lt;a href=&#034;/author/Klecun-Dabrowska&#034;&gt;Ela Klecun-Dabrowska&lt;/a&gt;, &lt;a href=&#034;/author/Pries-Heje&#034;&gt;Jan Pries-Heje&lt;/a&gt;, &lt;a href=&#034;/author/Tamm&#034;&gt;Gerrit Tamm&lt;/a&gt;, &lt;a href=&#034;/author/Telesko&#034;&gt;Rainer Telesko&lt;/a&gt;, &lt;a href=&#034;/author/Truch&#034;&gt;Edward Truch&lt;/a&gt;,  and &lt;a href=&#034;/author/Yetim&#034;&gt;Fahri Yetim&lt;/a&gt; &lt;/span&gt;&lt;em&gt;ECIS, &lt;/em&gt;&lt;em&gt;page 131-135. &lt;/em&gt;(&lt;em&gt;2002&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/242f02f01f4af7f3b0e7e541a3edd16e6/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/242f02f01f4af7f3b0e7e541a3edd16e6/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#InProceedings"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/conf/ecis/ecis2002.html#SnisEGKPTTTY02"/><swrc:date>Wed Nov 23 00:00:00 CET 2011</swrc:date><swrc:booktitle>ECIS</swrc:booktitle><swrc:crossref>conf/ecis/2002</swrc:crossref><swrc:pages>131-135</swrc:pages><swrc:title>Panel: Different approaches to evaluation of information systems.</swrc:title><swrc:year>2002</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://is2.lse.ac.uk/asp/aspecis/20020075.pdf" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Lundh Snis"/></rdf:_1><rdf:_2><swrc:Person swrc:name="Owen Eriksson"/></rdf:_2><rdf:_3><swrc:Person swrc:name="Kerstin Grundén"/></rdf:_3><rdf:_4><swrc:Person swrc:name="Ela Klecun-Dabrowska"/></rdf:_4><rdf:_5><swrc:Person swrc:name="Jan Pries-Heje"/></rdf:_5><rdf:_6><swrc:Person swrc:name="Gerrit Tamm"/></rdf:_6><rdf:_7><swrc:Person swrc:name="Rainer Telesko"/></rdf:_7><rdf:_8><swrc:Person swrc:name="Edward Truch"/></rdf:_8><rdf:_9><swrc:Person swrc:name="Fahri Yetim"/></rdf:_9></rdf:Seq></swrc:author><swrc:editor><rdf:Seq><rdf:_1><swrc:Person swrc:name="Stanislaw Wrycza"/></rdf:_1></rdf:Seq></swrc:editor></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/2df395c38f71bc31ba28abeebd22e2023/dblp"><title>Towards work-integrated learning communities.</title><link>http://www.bibsonomy.org/bibtex/2df395c38f71bc31ba28abeebd22e2023/dblp</link><dc:creator>dblp</dc:creator><dc:date>2011-11-23T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Snis&#034;&gt;Ulrika Lundh Snis&lt;/a&gt;, &lt;a href=&#034;/author/Svensson&#034;&gt;Lars Svensson&lt;/a&gt;,  and &lt;a href=&#034;/author/Östlund&#034;&gt;Christian Östlund&lt;/a&gt; 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Westergren&lt;/a&gt; &lt;/span&gt;&lt;em&gt;Inf. Syst. E-Business Management&lt;/em&gt; &lt;em&gt;9(2):223-245&lt;/em&gt; (&lt;em&gt;2011&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/2a2377338e25c8c57f9c342b053f906cb/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/2a2377338e25c8c57f9c342b053f906cb/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#Article"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/journals/isem/isem9.html#Westergren11"/><swrc:date>Mon May 23 00:00:00 CEST 2011</swrc:date><swrc:journal>Inf. Syst. E-Business Management</swrc:journal><swrc:number>2</swrc:number><swrc:pages>223-245</swrc:pages><swrc:title>Opening up innovation: the impact of contextual factors on the co-creation of IT-enabled value adding services within the manufacturing industry.</swrc:title><swrc:volume>9</swrc:volume><swrc:year>2011</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://dx.doi.org/10.1007/s10257-010-0144-2" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika H. Westergren"/></rdf:_1></rdf:Seq></swrc:author></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/24eda47ee1680b98b8deb12df8dc4152c/yish"><title>Learning Patterns for the design and deployment of Mathematical Games: Literature review</title><link>http://www.bibsonomy.org/bibtex/24eda47ee1680b98b8deb12df8dc4152c/yish</link><dc:creator>yish</dc:creator><dc:date>2011-02-04T12:18:59+01:00</dc:date><dc:subject>design designpatterns games haifa-edtech learning mathgamespatterns my myown polonsky </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Mark&#034;&gt;Childs Mark&lt;/a&gt;, &lt;a href=&#034;/author/Yishay&#034;&gt;Mor Yishay&lt;/a&gt;, &lt;a href=&#034;/author/Niall&#034;&gt;Winters Niall&lt;/a&gt;, &lt;a href=&#034;/author/Michele&#034;&gt;Cerulli Michele&lt;/a&gt;, &lt;a href=&#034;/author/Staffan&#034;&gt;Björk Staffan&lt;/a&gt;, &lt;a href=&#034;/author/Efi&#034;&gt;Alexopoulou Efi&lt;/a&gt;, &lt;a href=&#034;/author/Ulrika&#034;&gt;Bennerstedt Ulrika&lt;/a&gt;, &lt;a href=&#034;/author/Vincent&#034;&gt;Jonker Vincent&lt;/a&gt;, &lt;a href=&#034;/author/Chronis&#034;&gt;Kynigos Chronis&lt;/a&gt;, &lt;a href=&#034;/author/Dave&#034;&gt;Pratt Dave&lt;/a&gt;,  and &lt;a href=&#034;/author/Monica&#034;&gt;Wijers Monica&lt;/a&gt; &lt;/span&gt;&lt;em&gt;Research Report, &lt;/em&gt;&lt;em&gt;D40.1.1. &lt;/em&gt;&lt;em&gt;Kaleidoscope network of excellence, &lt;/em&gt;(&lt;em&gt;2006&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/design"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/designpatterns"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/games"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/haifa-edtech"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/learning"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/mathgamespatterns"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/my"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/myown"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/polonsky"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/24eda47ee1680b98b8deb12df8dc4152c/yish"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/24eda47ee1680b98b8deb12df8dc4152c/yish"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#TechnicalReport"/><owl:sameAs rdf:resource="http://telearn.noe-kaleidoscope.org/open-archive/browse?resource=257"/><swrc:date>Fri Feb 04 12:18:59 CET 2011</swrc:date><swrc:institution><swrc:Organization swrc:name="Kaleidoscope network of excellence "/></swrc:institution><swrc:number>D40.1.1</swrc:number><swrc:title>Learning Patterns for the design and deployment of Mathematical Games: Literature review</swrc:title><swrc:type>Research Report</swrc:type><swrc:year>2006</swrc:year><swrc:keywords>design designpatterns games haifa-edtech learning mathgamespatterns my myown polonsky </swrc:keywords><swrc:abstract>This literature review is intended as an introduction to the issues that arise when trying to capture the process of designing and developing mathematical games. It offers a perspective on the range of approaches available. Design patterns are suggested as an enabling tool for good practice, by facilitating pattern-specific communication and knowledge sharing between participants. These patterns are termed learning patterns, and they will be available as an outcome of this project.</swrc:abstract><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Childs Mark"/></rdf:_1><rdf:_2><swrc:Person swrc:name="Mor Yishay"/></rdf:_2><rdf:_3><swrc:Person swrc:name="Winters Niall"/></rdf:_3><rdf:_4><swrc:Person swrc:name="Cerulli Michele"/></rdf:_4><rdf:_5><swrc:Person swrc:name="Björk Staffan"/></rdf:_5><rdf:_6><swrc:Person swrc:name="Alexopoulou Efi"/></rdf:_6><rdf:_7><swrc:Person swrc:name="Bennerstedt Ulrika"/></rdf:_7><rdf:_8><swrc:Person swrc:name="Jonker Vincent"/></rdf:_8><rdf:_9><swrc:Person swrc:name="Kynigos Chronis"/></rdf:_9><rdf:_10><swrc:Person swrc:name="Pratt Dave"/></rdf:_10><rdf:_11><swrc:Person swrc:name="Wijers Monica"/></rdf:_11></rdf:Seq></swrc:author></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/2789586cdba9a98ce09bc58dd435fda42/dblp"><title>Knowing the Way. Managing Epistemic Topologies in Virtual Game Worlds.</title><link>http://www.bibsonomy.org/bibtex/2789586cdba9a98ce09bc58dd435fda42/dblp</link><dc:creator>dblp</dc:creator><dc:date>2011-01-14T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Bennerstedt&#034;&gt;Ulrika Bennerstedt&lt;/a&gt;,  and &lt;a href=&#034;/author/Ivarsson&#034;&gt;Jonas Ivarsson&lt;/a&gt; &lt;/span&gt;&lt;em&gt;Computer Supported Cooperative Work&lt;/em&gt; &lt;em&gt;19(2):201-230&lt;/em&gt; (&lt;em&gt;2010&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/2789586cdba9a98ce09bc58dd435fda42/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/2789586cdba9a98ce09bc58dd435fda42/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#Article"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/journals/cscw/cscw19.html#BennerstedtI10"/><swrc:date>Fri Jan 14 00:00:00 CET 2011</swrc:date><swrc:journal>Computer Supported Cooperative Work</swrc:journal><swrc:number>2</swrc:number><swrc:pages>201-230</swrc:pages><swrc:title>Knowing the Way. Managing Epistemic Topologies in Virtual Game Worlds.</swrc:title><swrc:volume>19</swrc:volume><swrc:year>2010</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://dx.doi.org/10.1007/s10606-010-9109-8" swrc:key="ee"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Bennerstedt"/></rdf:_1><rdf:_2><swrc:Person swrc:name="Jonas Ivarsson"/></rdf:_2></rdf:Seq></swrc:author></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/254b1c1eddd7f4d4c21b564dde26e3249/dblp"><title>Open Innovation Success or Failure - The Impact of Contextual Factors.</title><link>http://www.bibsonomy.org/bibtex/254b1c1eddd7f4d4c21b564dde26e3249/dblp</link><dc:creator>dblp</dc:creator><dc:date>2010-03-10T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Westergren&#034;&gt;Ulrika H. Westergren&lt;/a&gt; &lt;/span&gt;&lt;em&gt;HICSS, &lt;/em&gt;&lt;em&gt;page 1-10. &lt;/em&gt;&lt;em&gt;IEEE Computer Society, &lt;/em&gt;(&lt;em&gt;2010&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/254b1c1eddd7f4d4c21b564dde26e3249/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/254b1c1eddd7f4d4c21b564dde26e3249/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#InProceedings"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/conf/hicss/hicss2010.html#Westergren10"/><swrc:date>Wed Mar 10 00:00:00 CET 2010</swrc:date><swrc:booktitle>HICSS</swrc:booktitle><swrc:crossref>conf/hicss/2010</swrc:crossref><swrc:pages>1-10</swrc:pages><swrc:publisher><swrc:Organization swrc:name="IEEE Computer Society"/></swrc:publisher><swrc:title>Open Innovation Success or Failure - The Impact of Contextual Factors.</swrc:title><swrc:year>2010</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://doi.ieeecomputersociety.org/10.1109/HICSS.2010.467" swrc:key="ee"/></swrc:hasExtraField><swrc:hasExtraField><swrc:Field swrc:value="978-0-7695-3869-3" swrc:key="isbn"/></swrc:hasExtraField><swrc:hasExtraField><swrc:Field swrc:value="2010-03-10" swrc:key="date"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika H. Westergren"/></rdf:_1></rdf:Seq></swrc:author></rdf:Description></burst:publication><description>dblp</description></item><item rdf:about="http://www.bibsonomy.org/bibtex/20ecef74954a02ecff6a6f127c77f7dd4/hruehs"><title>Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis</title><link>http://www.bibsonomy.org/bibtex/20ecef74954a02ecff6a6f127c77f7dd4/hruehs</link><dc:creator>hruehs</dc:creator><dc:date>2010-02-04T16:31:48+01:00</dc:date><dc:subject>Analysis Chemical Factors Gentamicinspharmacokineticspharmacology Humans Models, Pefloxacinpharmacokineticspharmacology Pharmacokinetics Pharmacology Pyrimidinespharmacokineticspharmacology Regression Time Triazolespharmacokineticspharmacology </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Wählby&#034;&gt;Ulrika Wählby&lt;/a&gt;, &lt;a href=&#034;/author/Thomson&#034;&gt;Alison H. Thomson&lt;/a&gt;, &lt;a href=&#034;/author/Milligan&#034;&gt;Peter A. Milligan&lt;/a&gt;,  and &lt;a href=&#034;/author/Karlsson&#034;&gt;Mats O. Karlsson&lt;/a&gt; &lt;/span&gt;&lt;em&gt;British Journal of Clinical Pharmacology&lt;/em&gt; &lt;em&gt;58(4):367-377&lt;/em&gt; (&lt;em&gt;2004&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Analysis"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Chemical"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Factors"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Gentamicinspharmacokineticspharmacology"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Humans"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Models,"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Pefloxacinpharmacokineticspharmacology"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Pharmacokinetics"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Pharmacology"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Pyrimidinespharmacokineticspharmacology"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Regression"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Time"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Triazolespharmacokineticspharmacology"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/20ecef74954a02ecff6a6f127c77f7dd4/hruehs"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/20ecef74954a02ecff6a6f127c77f7dd4/hruehs"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#Article"/><swrc:date>Thu Feb 04 16:31:48 CET 2010</swrc:date><swrc:journal>British Journal of Clinical Pharmacology</swrc:journal><swrc:number>4</swrc:number><swrc:pages>367-377</swrc:pages><swrc:title>Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis</swrc:title><swrc:volume>58</swrc:volume><swrc:year>2004</swrc:year><swrc:keywords>Analysis Chemical Factors Gentamicinspharmacokineticspharmacology Humans Models, Pefloxacinpharmacokineticspharmacology Pharmacokinetics Pharmacology Pyrimidinespharmacokineticspharmacology Regression Time Triazolespharmacokineticspharmacology </swrc:keywords><swrc:abstract>AIM: If appropriately accounted for in a pharmacokinetic (PK)-pharmacodynamic (PD) model, time-varying covariates can provide additional information to that obtained from time-constant covariates. The aim was to present and apply two models applicable to time-varying covariates that capture such additional information. METHODS: The first model estimates different covariate-parameter relationships for within- and between-individual variation in covariate values, by splitting the standard covariate model into a baseline covariate (BCOV) effect and a difference from baseline covariate (DCOV) effect. The second model allows the magnitude of the covariate effect to vary between individuals, by inclusion of interindividual variability in the covariate effect. The models were applied to four previously analysed data sets. RESULTS: The models were applied to 10 covariate-parameter relationships and for three of these the first extended model resulted in a significant improvement of the fit. Ev</swrc:abstract><swrc:hasExtraField><swrc:Field swrc:value="1365-2125" swrc:key="issn"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Wählby"/></rdf:_1><rdf:_2><swrc:Person swrc:name="Alison H. Thomson"/></rdf:_2><rdf:_3><swrc:Person swrc:name="Peter A. Milligan"/></rdf:_3><rdf:_4><swrc:Person swrc:name="Mats O. Karlsson"/></rdf:_4></rdf:Seq></swrc:author></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/291b3044d82975a6d97f72655ab2a3813/hruehs"><title>Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis</title><link>http://www.bibsonomy.org/bibtex/291b3044d82975a6d97f72655ab2a3813/hruehs</link><dc:creator>hruehs</dc:creator><dc:date>2010-02-04T16:31:48+01:00</dc:date><dc:subject>Bias Models, Pharmacokinetics Predictive Selection Statistical Tests Value of </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Wählby&#034;&gt;Ulrika Wählby&lt;/a&gt;, &lt;a href=&#034;/author/Jonsson&#034;&gt;E. Niclas Jonsson&lt;/a&gt;,  and &lt;a href=&#034;/author/Karlsson&#034;&gt;Mats O. Karlsson&lt;/a&gt; &lt;/span&gt;&lt;em&gt;AAPS pharmSci&lt;/em&gt; &lt;em&gt;4(4):E27&lt;/em&gt; (&lt;em&gt;2002&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Bias"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Models,"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Pharmacokinetics"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Predictive"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Selection"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Statistical"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Tests"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/Value"/><rdf:li rdf:resource="http://www.bibsonomy.org/tag/of"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/291b3044d82975a6d97f72655ab2a3813/hruehs"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/291b3044d82975a6d97f72655ab2a3813/hruehs"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#Article"/><owl:sameAs rdf:resource="/brokenurl#doi:10.1208/ps040427"/><swrc:date>Thu Feb 04 16:31:48 CET 2010</swrc:date><swrc:journal>AAPS pharmSci</swrc:journal><swrc:number>4</swrc:number><swrc:pages>E27</swrc:pages><swrc:title>Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis</swrc:title><swrc:volume>4</swrc:volume><swrc:year>2002</swrc:year><swrc:keywords>Bias Models, Pharmacokinetics Predictive Selection Statistical Tests Value of </swrc:keywords><swrc:abstract>The aim of this study was to compare 2 stepwise covariate model-building strategies, frequently used in the analysis of pharmacokinetic-pharmacodynamic (PK-PD) data using nonlinear mixed-effects models, with respect to included covariates and predictive performance. In addition, the effects of stepwise regression on the estimated covariate coefficients were assessed. Using simulated and real PK data, covariate models were built applying (1) stepwise generalized additive models (GAM) for identifying potential covariates, followed by backward elimination in the computer program NONMEM, and (2) stepwise forward inclusion and backward elimination in NONMEM. Different versions of these procedures were tried (eg, treating different study occasions as separate individuals in the GAM, or fixing a part of the parameters when the NONMEM procedure was used). The final covariate models were compared, including their ability to predict a separate data set or their performance in cross-validation. T</swrc:abstract><swrc:hasExtraField><swrc:Field swrc:value="1522-1059" swrc:key="issn"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Wählby"/></rdf:_1><rdf:_2><swrc:Person swrc:name="E. Niclas Jonsson"/></rdf:_2><rdf:_3><swrc:Person swrc:name="Mats O. Karlsson"/></rdf:_3></rdf:Seq></swrc:author></rdf:Description></burst:publication></item><item rdf:about="http://www.bibsonomy.org/bibtex/28733ded371c043bb2254fe5cc3f43146/dblp"><title>Coping with Illness Online: The Case of Patients&#039;Online Communities.</title><link>http://www.bibsonomy.org/bibtex/28733ded371c043bb2254fe5cc3f43146/dblp</link><dc:creator>dblp</dc:creator><dc:date>2009-11-11T00:00:00+01:00</dc:date><dc:subject>dblp </dc:subject><content:encoded>&lt;span class=&#034;authorEditorList&#034;&gt;&lt;a href=&#034;/author/Josefsson&#034;&gt;Ulrika Josefsson&lt;/a&gt; &lt;/span&gt;&lt;em&gt;Inf. Soc.&lt;/em&gt; &lt;em&gt;21(2):133-141&lt;/em&gt; (&lt;em&gt;2005&lt;/em&gt;)</content:encoded><taxo:topics><rdf:Bag><rdf:li rdf:resource="http://www.bibsonomy.org/tag/dblp"/></rdf:Bag></taxo:topics><burst:publication><rdf:Description rdf:about="http://www.bibsonomy.org/bibtex/28733ded371c043bb2254fe5cc3f43146/dblp"><owl:sameAs rdf:resource="http://www.bibsonomy.org/uri/bibtex/28733ded371c043bb2254fe5cc3f43146/dblp"/><rdf:type rdf:resource="http://swrc.ontoware.org/ontology#Article"/><owl:sameAs rdf:resource="http://dblp.uni-trier.de/db/journals/tis/tis21.html#Josefsson05"/><swrc:date>Wed Nov 11 00:00:00 CET 2009</swrc:date><swrc:journal>Inf. Soc.</swrc:journal><swrc:number>2</swrc:number><swrc:pages>133-141</swrc:pages><swrc:title>Coping with Illness Online: The Case of Patients&#039;Online Communities.</swrc:title><swrc:volume>21</swrc:volume><swrc:year>2005</swrc:year><swrc:keywords>dblp </swrc:keywords><swrc:hasExtraField><swrc:Field swrc:value="http://dx.doi.org/10.1080/01972240590925357" swrc:key="ee"/></swrc:hasExtraField><swrc:hasExtraField><swrc:Field swrc:value="2009-11-11" swrc:key="date"/></swrc:hasExtraField><swrc:author><rdf:Seq><rdf:_1><swrc:Person swrc:name="Ulrika Josefsson"/></rdf:_1></rdf:Seq></swrc:author></rdf:Description></burst:publication><description>dblp</description></item></rdf:RDF>
