BibSonomyburst/tag/behaviorBibSonomy RSS feed for /tag/behavior2012-02-15T11:09:20+01:00http://www.bibsonomy.org/bibtex/2c00eeb4997f4f6a2f28cbeb02f5cb7f6/khilgenbergkhilgenberg2012-01-26T13:12:53+01:002011 behavior kde seminar twitter user <span class="authorEditorList"><a href="/author/Krishnamurthy">B. Krishnamurthy</a>, <a href="/author/Gill">P. Gill</a>, and <a href="/author/Arlitt">M. Arlitt</a> </span><em>Proceedings of the first workshop on Online social networks, </em><em>page 19--24. </em><em>ACM, </em>(<em>2008</em>)Thu Jan 26 13:12:53 CET 2012{Proceedings of the first workshop on Online social networks}19--24{A Few Chirps About Twitter.}20082011 behavior kde seminar twitter user http://www.bibsonomy.org/bibtex/2bc08f76536610f3f376bece5f0b46ad5/chriskoernerchriskoerner2012-01-23T09:27:43+01:00behavior mobile tagging taggingsurvey <span class="authorEditorList"><a href="/author/Ames">Morgan Ames</a>, and <a href="/author/Naaman">Mor Naaman</a> </span><em>Proceedings of the SIGCHI conference on Human factors in computing systems, </em><em>page 971--980. </em><em>New York, NY, USA, </em><em>ACM, </em>(<em>2007</em>)Mon Jan 23 09:27:43 CET 2012New York, NY, USAProceedings of the SIGCHI conference on Human factors in computing systems971--980CHI '07Why we tag: motivations for annotation in mobile and online media2007behavior mobile tagging taggingsurvey Why do people tag? Users have mostly avoided annotating media such as photos -- both in desktop and mobile environments -- despite the many potential uses for annotations, including recall and retrieval. We investigate the incentives for annotation in Flickr, a popular web-based photo-sharing system, and ZoneTag, a cameraphone photo capture and annotation tool that uploads images to Flickr. In Flickr, annotation (as textual tags) serves both personal and social purposes, increasing incentives for tagging and resulting in a relatively high number of annotations. ZoneTag, in turn, makes it easier to tag cameraphone photos that are uploaded to Flickr by allowing annotation and suggesting relevant tags immediately after capture.</p> <p>A qualitative study of ZoneTag/Flickr users exposed various tagging patterns and emerging motivations for photo annotation. We offer a taxonomy of motivations for annotation in this system along two dimensions (sociality and function), and explore the various factors that people consider when tagging their photos. Our findings suggest implications for the design of digital photo organization and sharing applications, as well as other applications that incorporate user-based annotation.Why we taghttp://www.bibsonomy.org/bibtex/2223252f6fc636962e57bab176a0594ef/griesbaugriesbau2011-12-15T15:42:35+01:00Behavior Human Information bisibs <span class="authorEditorList"><a href="/author/Wilson">Thomas D. Wilson</a> </span><em>Informing Science</em> <em>3(2):49-56</em> (<em>2000</em>)Thu Dec 15 15:42:35 CET 2011Informing Science249-56Human Information Behavior32000Behavior Human Information bisibs This paper provides a history and overview of the field of human information behavior, including recent advances in the field and multidisciplinary perspectives. http://www.bibsonomy.org/bibtex/25a74cfff61969b97fddb73f11e64e2e8/khilgenbergkhilgenberg2011-12-01T13:47:17+01:002011 behavior kde seminar spam twitter user <span class="authorEditorList"><a href="/author/Krishnamurthy">B. Krishnamurthy</a>, <a href="/author/Gill">P. Gill</a>, and <a href="/author/Arlitt">M. Arlitt</a> </span><em>Proceedings of the first workshop on Online social networks, </em><em>page 19--24. </em><em>ACM, </em>(<em>2008</em>)Thu Dec 01 13:47:17 CET 2011Proceedings of the first workshop on Online social networks19--24A few chirps about twitter20082011 behavior kde seminar spam twitter user http://www.bibsonomy.org/bibtex/27d2ffb5d43a46707fc481dad3440d7d7/katjabarankatjabaran2011-11-17T09:44:52+01:00&#034;irhhu“ Gender Information Search behavior differences empirical engine gender information retrieval search seekingbehavior study <span class="authorEditorList"><a href="/author/Maghferat"> Maghferat</a>, and <a href="/author/Stock">W.G Stock</a> </span><em>Webology</em> (<em>December 2010</em>)Thu Nov 17 09:44:52 CET 2011WebologyDecemberNumber 2Gender-specific information search behaviorVolume 72010"irhhu“ Gender Information Search behavior differences empirical engine gender information retrieval search seekingbehavior study This paper presents an empirical gender study in the context of information science. It discusses an exploratory investigation, which provides empirical data about differences of information seeking activities by female and male students. The research focus was on whether there are gender-specific differences when people perform searches with the aid of general search engines and specialized Deep Web information services. It has been observed how the participants behaved in getting information and how the gender groups differ from each other. Which search system (search engine or professional information supplier) has been preferred by the gender groups at first? How did the gender groups search (applied operators, modifications of query formulations, targeted search)? How far were the users satisfied with their results? For data collection paper-questionnaires have been used and the answers have been statistically analyzed with the help of SPSS. The questionnaire consisted of four different search tasks each with seven sub-questions. The research and the obtained result data indicate at least in the choice of search sources, the satisfaction with this source and the results obtained a gender-specific difference. Men tried to use professional information services as well as search engines for search, regardless of the difficulty of the search task and its formulation. In contrast, women behaved cautiously in choosing search sources. They decided either on sources, which they knew skillfully or where their use was assigned. Women were generally more satisfied with the obtained results as men. These data can represent an initial approach for further analysis of gender-specific Web search behavior.http://www.bibsonomy.org/bibtex/21aa37b0f1b2b982cf3060bb7fe2eb471/pawelsikorskipawelsikorski2011-11-04T13:47:04+01:00*Cell *Motor ; Acrylic Activity Analysis Animals Behavior Biopolymers Capsules Cell Cells Chloride Corpus Division Dopamine/*metabolism Gov&#039;t Gov&#039;t, Male Neoplasm Non-U.S. Oxidopamine P.H.S. PC12 Polyvinyl Rats Rats, Research Resins Sprague-Dawley Stereotyped Striatum/metabolism/pathology Support, Survival Transplantation/physiology U.S. Variance of <span class="authorEditorList"><a href="/author/Tresco">P. A. Tresco</a>, <a href="/author/Winn">S. R. Winn</a>, <a href="/author/Tan">S. Tan</a>, <a href="/author/Jaeger">C. B. Jaeger</a>, <a href="/author/Greene">L. A. Greene</a>, and <a href="/author/Aebischer">P. Aebischer</a> </span><em>Cell Transplant</em> <em>1(2-3):255-64</em> (<em>1992</em>)Fri Nov 04 13:47:04 CET 2011Cell Transplant2-3255-64Polymer-encapsulated PC12 cells: long-term survival and associated reduction in lesion-induced rotational behavior.11992*Cell *Motor ; Acrylic Activity Analysis Animals Behavior Biopolymers Capsules Cell Cells Chloride Corpus Division Dopamine/*metabolism Gov't Gov't, Male Neoplasm Non-U.S. Oxidopamine P.H.S. PC12 Polyvinyl Rats Rats, Research Resins Sprague-Dawley Stereotyped Striatum/metabolism/pathology Support, Survival Transplantation/physiology U.S. Variance of Intrastriatal implantation of a dopaminergic cell line surrounded by a permeable, thermoplastic membrane was investigated as a method of long-term dopamine (DA) delivery within the central nervous system (CNS). An increase in DA release from PC12 cell-loaded capsules maintained in vitro was associated with an increase in mitotic activity of the encapsulated cell line. A significant reduction in apomorphine-induced rotational behavior was observed after PC12 cell-containing capsules were implanted into unilaterally 6-hydroxydopamine (6-OHDA) lesioned rats, which was sustained for 24 wk. Four wk after implantation, microdialysis studies revealed the presence of DA near PC12 cell-containing capsules, which was comparable to extracellular striatal levels of unlesioned controls. Extracellular striatal DA was undetectable by microdialysis in lesioned animals near empty polymer capsules. Histological analysis after 24 wk in vivo demonstrated that encapsulated PC12 cells survived, continued to express tyrosine hydroxylase, and that encapsulation prevented tumorigenesis. The data suggested that the release of a diffusible substance, most likely DA, from an implant is sufficient to exert a long-term functional influence upon 6-OHDA unilaterally lesioned rats and that capsules containing DA-secreting cells may be an effective method of long-term DA delivery in the CNS.http://www.bibsonomy.org/bibtex/27316d89b36608ea520dff7757e9e3e87/pawelsikorskipawelsikorski2011-11-04T13:47:04+01:00;; [ISI:] aqueous bacterial behavior electron-microscopy; polysaccharide; sodium-chloride; <span class="authorEditorList"><a href="/author/CHRISTENSEN">B. E. CHRISTENSEN</a>, <a href="/author/KNUDSEN">K. D. KNUDSEN</a>, <a href="/author/SMIDSROD">O. SMIDSROD</a>, <a href="/author/KITAMURA">S. KITAMURA</a>, and <a href="/author/TAKEO">K. TAKEO</a> </span><em>Biopolymers</em> <em>33(1):151 -- 161</em> (<em>January 1993</em>)Fri Nov 04 13:47:04 CET 2011605 THIRD AVE, NEW YORK, NY 10158-0012BiopolymersJAN1151 -- 161TEMPERATURE-INDUCED CONFORMATIONAL TRANSITION IN XANTHANS WITH PARTIALLY HYDROLYZED SIDE-CHAINS331993;; [ISI:] aqueous bacterial behavior electron-microscopy; polysaccharide; sodium-chloride; The conformational properties of xanthans with partially hydrolyzed side chains were investigated by optical rotation, CD, and differential scanning calorimetry (DSC). All variants displayed the well-known temperature-driven, cooperative order-disorder transition, and both optical rotation and DSC showed that the transition temperature was essentially independent of the content of terminal beta-mannose. It was found that up to 80% of the changes in the specific optical rotation accompanying the transition reflects conformational changes linked to the terminal beta-mannose in the side chains. Modification of the side chains also affected the CD when xanthan was in the ordered state, but in this case the data suggest that the glucuronic acid is the major component determining the magnitude of the CD signal. DSC measurements showed that the transition enthalpy (DELTAH(cal)) increased linearly with the fraction of beta-mannose, again indicating that a significant part (up to 80%) of DELTAH(cal) reflects conformational changes in the side chains. The conformational transition of the xanthan variants generally showed a higher degree of cooperativity (sharper transition) than unmodified, pyruvated xanthan. Calculation of the cooperativity parameter sigma by means of the Zimm-Bragg theory (OR data) or from the ratio between DELTAH(cal) and the van't Hoff enthalpy (DELTAH(v)H) Using DSC data showed a correlation between sigma and the content of beta-mannose, but the two methods gave different results when the content of beta-mannose approached 100%. The ionic strength dependence of the transition temperature, expressed as d(log I)/d(T(m)-1), was nearly identical for intact xanthan and a sample containing only 6% of the terminal beta-mannose. Application of the Manning polyelectrolyte theory does not readily account for the observed DELTAH(cal) values, neither does it provide new information on the nature of the ordered and disordered conformations in xanthan.http://www.bibsonomy.org/bibtex/2b6936c6cef57987fdc1282fb78d9dd27/griesbaugriesbau2011-11-03T16:40:02+01:00Attitude Behavior Belief Intention Introduction Research Theory <span class="authorEditorList"><a href="/author/Fishbein">Martin Fishbein</a>, and <a href="/author/Ajzen">Icek Ajzen</a> </span><em>Addison-Wesley, </em><em>Reading, MA, </em>(<em>1975</em>)Thu Nov 03 16:40:02 CET 2011Reading, MABelief, Attitude, Intention, and Behavior: An Introduction to Theory and Research. 1975Attitude Behavior Belief Intention Introduction Research Theory http://www.bibsonomy.org/bibtex/20ae08edd5af8d29d7c3ab38a0b395278/griesbaugriesbau2011-11-02T13:23:53+01:00Characterizing behavior cvk networks om09 online social user <span class="authorEditorList"><a href="/author/Benevenuto">Fabrício Benevenuto</a>, <a href="/author/Rodrigues">Tiago Rodrigues</a>, <a href="/author/Cha">Meeyoung Cha</a>, and <a href="/author/Almeida">Virgílio Almeida</a> </span><em>Proceedings of the 9th ACM SIGCOMM conference on Internet measurement conference, </em><em>page 49--62. </em><em>New York, NY, USA, </em><em>ACM, </em>(<em>2009</em>)Wed Nov 02 13:23:53 CET 2011New York, NY, USAProceedings of the 9th ACM SIGCOMM conference on Internet measurement conference49--62IMC '09Characterizing user behavior in online social networks2009Characterizing behavior cvk networks om09 online social user Understanding how users behave when they connect to social networking sites creates opportunities for better interface design, richer studies of social interactions, and improved design of content distribution systems. In this paper, we present a first of a kind analysis of user workloads in online social networks. Our study is based on detailed clickstream data, collected over a 12-day period, summarizing HTTP sessions of 37,024 users who accessed four popular social networks: Orkut, MySpace, Hi5, and LinkedIn. The data were collected from a social network aggregator website in Brazil, which enables users to connect to multiple social networks with a single authentication. Our analysis of the clickstream data reveals key features of the social network workloads, such as how frequently people connect to social networks and for how long, as well as the types and sequences of activities that users conduct on these sites. Additionally, we crawled the social network topology of Orkut, so that we could analyze user interaction data in light of the social graph. Our data analysis suggests insights into how users interact with friends in Orkut, such as how frequently users visit their friends' or non-immediate friends' pages. In summary, our analysis demonstrates the power of using clickstream data in identifying patterns in social network workloads and social interactions. Our analysis shows that browsing, which cannot be inferred from crawling publicly available data, accounts for 92% of all user activities. Consequently, compared to using only crawled data, considering silent interactions like browsing friends' pages increases the measured level of interaction among users.Characterizing user behavior in online social networkshttp://www.bibsonomy.org/bibtex/2e0d3f002c2c998f83f7d4e695b2c13d0/griesbaugriesbau2011-11-02T13:15:14+01:00and behavior being ecommerce engaged impact information networked networking om09 smm social <span class="authorEditorList"><a href="/author/Jansen">Bernard J. Jansen</a>, <a href="/author/Sobel">Kate Sobel</a>, and <a href="/author/Cook">Geoff Cook</a> </span><em>Proceedings of the 2011 iConference, </em><em>page 130--136. </em><em>New York, NY, USA, </em><em>ACM, </em>(<em>2011</em>)Wed Nov 02 13:15:14 CET 2011New York, NY, USAProceedings of the 2011 iConference130--136iConference '11Being networked and being engaged: the impact of social networking on ecommerce information behavior2011and behavior being ecommerce engaged impact information networked networking om09 smm social Teenagers and young adults born between 1981 and 2000 are a critical demographic group economically and are one of the first demographics presented with an array of Internet social networking services just as their online habits are forming. Based on a survey of 34,514 teen and young adult respondents, the research reported in this paper is a descriptive and inferential analysis of reported ecommerce information behaviors on four social networking sites (Facebook, MySpace, myYearbook, and Twitter). We use k-means clustering analysis to find groups of these users based on their levels of <i>being networked</i> on and <i>being engaged</i> with social networking services. Results show that the majority of this demographic have accounts on multiple social networking sites and specific sites result in different information behaviors. More than 40% engage in three social networking sites and an additional 20% have four social networking accounts. We also found that there are distinct information behavioral differences among eight distinct clusters of users, indicating that companies may need to employ advanced analytical techniques to segment the youth market. We also investigate the motivations for using different social media sites. Findings show that this young demographic has complex ecommerce information behaviors that call for nuanced approaches in advertising, marketing, or other areas of information targeting.Being networked and being engagedhttp://www.bibsonomy.org/bibtex/2be7c5923fd4c85ffde61d986f03a58ea/griesbaugriesbau2011-09-21T16:58:44+02:00Behavior Information Libraries School Youth and behaviour bisibs2 dipf <span class="authorEditorList"><a href="/author/Dresang">Eliza T. Dresang</a>, and <a href="/author/Koh">Kyungwon Koh</a> </span><em>Library Trends</em> (<em>2009</em>)Wed Sep 21 16:58:44 CEST 2011Library Trends10Radical Change Theory, Youth Information Behavior, and School Libraries582009Behavior Information Libraries School Youth and behaviour bisibs2 dipf School libraries confront significant changes in the digital age, the age of Web 2.0 and of participatory culture. Radical Change theory, based on the digital age principles of interactivity, connectivity, and access, is germane to understanding these transformations. The theory was originally developed to explain changes in digital age books for youth. It is expanded here through the creation of a typology and accompanying characteristics that address how digital age youth think and seek information; perceive themselves and others; and access information and seek community. As a basis for their typology, the authors provide detailed evidence from an extensive interdisciplinary review of research literature concerning youth information behavior. Also proposed is a multistage research agenda that involves applying Radical Change theory in various school library settings for proof of concept followed by an exploration of potential associations between digital age youth information behaviors and twenty-first-century learning skills. This theory development will assist in determining what implications the new information behaviors and resources have for libraries, schools, and other information environments and how information professionals can better help youth become skilled twenty-first-century information seekers. http://www.bibsonomy.org/bibtex/28f99e00cc85cab474bb139808162ff2d/griesbaugriesbau2011-09-21T15:46:11+02:00behavior behaviour dipf information <span class="authorEditorList"><a href="/author/Bates">Marcia J. Bates</a> </span><em>Encyclopedia of Library and Information Sciences, </em><em> 3, </em><em>page 2381-2391. </em><em>New York, </em><em>CRC Press, </em>(<em>2010</em>)Wed Sep 21 15:46:11 CEST 2011New YorkEncyclopedia of Library and Information Sciences32381-2391Information Behavior 32010behavior behaviour dipf information "Information behavior" is the currently preferred term used to describe the many ways in which human beings interact with information, in particular, the ways in which people seek and utilize information. The broad history of research on information seeking behavior over the last 50-60 years is reviewed, major landmarks are identified, and current directions in research are discussed. http://www.bibsonomy.org/bibtex/263c4ede33460e585102498fde6e35df9/hdzhdz2011-09-14T13:38:11+02:00SocialMedia behavior consumer embeddedness online social socialcommerce <span class="authorEditorList"><a href="/author/Hess">Thomas Hess</a>, <a href="/author/Lang">Karl Lang</a>, and <a href="/author/Xu">Sean Xu</a> </span><em>Electronic Markets</em> (<em>2011</em>)<em>10.1007/s12525-011-0071-1 . </em>Wed Sep 14 13:38:11 CEST 2011Electronic Markets10.1007/s12525-011-0071-11-3Social embeddedness and online consumer behavior2011SocialMedia behavior consumer embeddedness online social socialcommerce http://www.bibsonomy.org/bibtex/2432d22e548de3e5d77f59443dca842bf/crc_chuscrc_chus2011-08-03T21:06:35+02:00Analgesia Animal Animals Behavior Freund&#039;s_Adjuvant Hyperalgesia Inbred_{C57BL} Inflammation Knockout Male Mice Models Neurons Oligopeptides Opioid Pain Pain_Measurement Protein_Precursors Receptors Substance_P Tachykinins delta <span class="authorEditorList"><a href="/author/Dubois">Dave Dubois</a>, and <a href="/author/Gendron">Louis Gendron</a> </span><em>The European Journal of Neuroscience</em> <em>32(11):1921--1929</em> (<em>December 2010</em>)<em>PMID: 21044181 . </em>Wed Aug 03 21:06:35 CEST 2011The European Journal of Neurosciencedec{PMID:} 21044181111921--1929Delta opioid receptor-mediated analgesia is not altered in preprotachykinin A knockout mice322010Analgesia Animal Animals Behavior Freund's_Adjuvant Hyperalgesia Inbred_{C57BL} Inflammation Knockout Male Mice Models Neurons Oligopeptides Opioid Pain Pain_Measurement Protein_Precursors Receptors Substance_P Tachykinins delta We have shown that delta opioid receptor {(DOPR)-mediated} analgesia was enhanced in the complete Freund's adjuvant {(CFA)} model of inflammation. This effect is thought to originate from translocation of {DOPR} in the plasma membrane of dorsal root ganglia and spinal cord neurons. Among the putative mechanisms involved in the regulation of {DOPR} trafficking, an interaction with substance P {(SP)} in large dense-core vesicles has been described as an essential event for the externalization of {DOPR.} As we have previously observed that membrane {DOPRs} were upregulated in small- and medium-sized neurons under inflammatory pain conditions (whereas {SP} is mainly expressed by small dorsal root ganglia neurons), we raised the hypothesis that an {SP-independent} mechanism mediates {DOPR} trafficking and functional emergence in the {CFA} model. Therefore, we investigated the role of {SP} in {DOPR-mediated} analgesia by using preprotachykinin A (precursor of {SP)} knockout mice {(PPTA(-/-)} ) in the {CFA} model of inflammation. First, we confirmed that {PPTA(-/-)} mice are not expressing {SP} and have a similar level of {CFA-induced} inflammation as wildtype mice. Then, using the thermal plantar test, we found that an intrathecal injection of deltorphin {II} induced {DOPR-mediated} antihyperalgesia, which was not modified by the absence of {SP} (similar efficacy and potency in wildtype and {PPTA(-/-)} mice). We also observed similar analgesia of intrathecal deltorphin {II} for {PPTA(-/-)} and wildtype mice in the hot-water immersion tail-flick test. Consequently, our results suggest that {SP} is not essential for membrane insertion and for the functional emergence of {DOPR.}http://www.bibsonomy.org/bibtex/2c7f30d0c45871a8af9102b89632dffba/crc_chuscrc_chus2011-08-03T17:38:07+02:00Afferent Analysis_of_Variance Animal Animals Behavior Calcitonin_{Gene-Related}_Peptide Calcium Chemokine_{CCL2} Ganglia Gene_Expression_Regulation Hyperalgesia Male Neurons Pain_Threshold Potassium_Chloride Pyrrolidines Rats Receptors Spinal Spinal_Cord Subcellular_Fractions Substance_P {CCR2} {Enzyme-Linked}_Immunosorbent_Assay {Sprague-Dawley} {TRPV}_Cation_Channels <span class="authorEditorList"><a href="/author/Dansereau">Marc-André Dansereau</a>, <a href="/author/Gosselin">Romain-Daniel Gosselin</a>, <a href="/author/Pohl">Michel Pohl</a>, <a href="/author/Pommier">Blandine Pommier</a>, <a href="/author/Mechighel">Patricia Mechighel</a>, <a href="/author/Mauborgne">Annie Mauborgne</a>, <a href="/author/Rostene">William Rostene</a>, <a href="/author/Kitabgi">Patrick Kitabgi</a>, <a href="/author/Beaudet">Nicolas Beaudet</a>, <a href="/author/Sarret">Philippe Sarret</a>, and <a href="/author/Melik-Parsadaniantz">Stéphane Melik-Parsadaniantz</a> </span><em>Journal of Neurochemistry</em> <em>106(2):757--769</em> (<em>July 2008</em>)<em>PMID: 18419759 . </em>Wed Aug 03 17:38:07 CEST 2011Journal of Neurochemistryjul{PMID:} 184197592757--769Spinal {CCL2} pronociceptive action is no longer effective in {CCR2} receptor antagonist-treated rats1062008Afferent Analysis_of_Variance Animal Animals Behavior Calcitonin_{Gene-Related}_Peptide Calcium Chemokine_{CCL2} Ganglia Gene_Expression_Regulation Hyperalgesia Male Neurons Pain_Threshold Potassium_Chloride Pyrrolidines Rats Receptors Spinal Spinal_Cord Subcellular_Fractions Substance_P {CCR2} {Enzyme-Linked}_Immunosorbent_Assay {Sprague-Dawley} {TRPV}_Cation_Channels A better understanding of the mechanisms linked to chemokine pronociceptive effects is essential for the development of new strategies to better prevent and treat chronic pain. Among chemokines, {MCP-1/CCL2} involvement in neuropathic pain processing is now established. However, the mechanisms by which {MCP-1/CCL2} exerts its pronociceptive effects are still poorly understood. In the present study, we demonstrate that {MCP-1/CCL2} can alter pain neurotransmission in healthy rats. Using immunohistochemical studies, we first show that {CCL2} is constitutively expressed by primary afferent neurons and their processes in the dorsal horn of the spinal cord. We also observe that {CCL2} is co-localized with pain-related peptides {(SP} and {CGRP)} and capsaicin receptor {(VR1).} Accordingly, using in vitro superfusion system of lumbar dorsal root ganglion and spinal cord explants of healthy rats, we show that potassium or capsaicin evoke calcium-dependent release of {CCL2.} In vivo, we demonstrate that intrathecal administration of {CCL2} to healthy rats produces both thermal hyperalgesia and sustained mechanical allodynia (up to four consecutive days). These pronociceptive effects of {CCL2} are completely prevented by the selective {CCR2} antagonist {(INCB3344)}, indicating that {CCL2-induced} pain facilitation is elicited via direct spinal activation of {CCR2} receptor. Therefore, preventing the activation of {CCR2} might provide a fruitful strategy for treating pain.http://www.bibsonomy.org/bibtex/2a51e3c61a67b8f75852ee2da888c5605/crc_chuscrc_chus2011-08-03T17:38:07+02:00Animal Animals Apoptosis Behavior Exploratory_Behavior Hippocampus Humans Immunohistochemistry Knockout Learning Male Mice Neurons Pyridines Pyrrolizidine_Alkaloids Quinone_Reductases Rats Recognition_{(Psychology)} Reverse_Transcriptase_Polymerase_Chain_Reaction Rotarod_Performance_Test Swimming {Long-Evans} {Sprague-Dawley} <span class="authorEditorList"><a href="/author/Benoit">Charles-Etienne Benoit</a>, <a href="/author/Bastianetto">Stephane Bastianetto</a>, <a href="/author/Brouillette">Jonathan Brouillette</a>, <a href="/author/Tse">YiuChung Tse</a>, <a href="/author/Boutin">Jean A Boutin</a>, <a href="/author/Delagrange">Philippe Delagrange</a>, <a href="/author/Wong">TakPan Wong</a>, <a href="/author/Sarret">Philippe Sarret</a>, and <a href="/author/Quirion">Rémi Quirion</a> </span><em>The Journal of Neuroscience: The Official Journal of the Society for Neuroscience</em> <em>30(38):12690--12700</em> (<em>September 2010</em>)<em>PMID: 20861374 . </em>Wed Aug 03 17:38:07 CEST 2011The Journal of Neuroscience: The Official Journal of the Society for Neurosciencesep{PMID:} 208613743812690--12700Loss of quinone reductase 2 function selectively facilitates learning behaviors302010Animal Animals Apoptosis Behavior Exploratory_Behavior Hippocampus Humans Immunohistochemistry Knockout Learning Male Mice Neurons Pyridines Pyrrolizidine_Alkaloids Quinone_Reductases Rats Recognition_{(Psychology)} Reverse_Transcriptase_Polymerase_Chain_Reaction Rotarod_Performance_Test Swimming {Long-Evans} {Sprague-Dawley} High levels of reactive oxygen species {(ROS)} are associated with deficits in learning and memory with age as well as in Alzheimer's disease. Using {DNA} microarray, we demonstrated the overexpression of quinone reductase 2 {(QR2)} in the hippocampus in two models of learning deficits, namely the aged memory impaired rats and the scopolamine-induced amnesia model. {QR2} is a cytosolic flavoprotein that catalyzes the reduction of its substrate and enhances the production of damaging activated quinone and {ROS.} {QR2-like} immunostaining is enriched in cerebral structures associated with learning behaviors, such as the hippocampal formation and the temporofrontal cortex of rat, mouse, and human brains. In cultured rat embryonic hippocampal neurons, selective inhibitors of {QR2}, namely S26695 and S29434, protected against menadione-induced cell death by reversing its proapoptotic action. S26695 (8 mg/kg) also significantly inhibited scopolamine-induced amnesia. Interestingly, adult {QR2} knock-out mice demonstrated enhanced learning abilities in various tasks, including Morris water maze, object recognition, and rotarod performance test. Other behaviors related to anxiety (elevated plus maze), depression (forced swim), and schizophrenia (prepulse inhibition) were not affected in {QR2-deficient} mice. Together, these data suggest a role for {QR2} in cognitive behaviors with {QR2} inhibitors possibly representing a novel therapeutic strategy toward the treatment of learning deficits especially observed in the aged brain.http://www.bibsonomy.org/bibtex/2b0f406f4e833fd87ff6bca2dc83ed682/crc_chuscrc_chus2011-08-03T17:38:07+02:00Animal Animals Behavior Central_Nervous_System Gene_Knockdown_Techniques Mice Pain Rats Ribonuclease_{III} Small_Interfering {RNA} {RNA}_Interference {Sprague-Dawley} <span class="authorEditorList"><a href="/author/Sarret">Philippe Sarret</a>, <a href="/author/Doré-Savard">Louis Doré-Savard</a>, and <a href="/author/Beaudet">Nicolas Beaudet</a> </span><em>Methods in Molecular Biology Clifton, N.J.</em> (<em>2010</em>)<em>PMID: 20217565 . </em>Wed Aug 03 17:38:07 CEST 2011Methods in Molecular Biology {(Clifton}, {N.J.)}{PMID:} 20217565383--395Direct application of {siRNA} for in vivo pain research6232010Animal Animals Behavior Central_Nervous_System Gene_Knockdown_Techniques Mice Pain Rats Ribonuclease_{III} Small_Interfering {RNA} {RNA}_Interference {Sprague-Dawley} Pain is the new burden of the twenty-first century, raising enormous socio-economic costs to developed and underdeveloped countries. Chronic pain is a central nervous system {(CNS)} pathology, affecting a large proportion of the population. Morphine and its derivatives are still the golden clinical standards for treating pain although they induce severe side effects. To this day, we still have poor understanding of nociceptive pain and its underlying complex mechanisms; furthermore, novelty in clinical analgesics is {lacking.RNA} interference technologies are promising both for pain research and treatment. This genetic approach will likely provide new insights into pain mechanisms and eventually offer nonpharmacological therapeutic approaches. In vivo research is thus crucial to reach this goal. Preclinical studies on rodents are necessary to validate small interfering {RNA} {(siRNA)} candidates and to target precise physiological pain modulators. Aiming treatment at the {CNS} is delicate work, and here we will describe how to perform adequate pain research using {siRNA}, including {siRNA} preparation and injection, animal behavioral models, and {CNS} tissue collection.http://www.bibsonomy.org/bibtex/2697c277116292814f57812cb18355967/griesbaugriesbau2011-06-30T16:22:28+02:00behavior goals information queries search serps <span class="authorEditorList"><a href="/author/Downey">Doug Downey</a>, <a href="/author/Dumais">Susan Dumais</a>, <a href="/author/Liebling">Dan Liebling</a>, and <a href="/author/Horvitz">Eric Horvitz</a> </span><em>Proceeding of the 17th ACM conference on Information and knowledge management, </em><em>page 449--458. </em><em>New York, NY, USA, </em><em>ACM, </em>(<em>2008</em>)Thu Jun 30 16:22:28 CEST 2011New York, NY, USAProceeding of the 17th ACM conference on Information and knowledge management449--458CIKM '08Understanding the relationship between searchers' queries and information goals2008behavior goals information queries search serps http://www.bibsonomy.org/bibtex/2fe46aa5a3a9e9ca3e0c76511637b0b81/yevb0yevb02011-03-27T17:20:41+02:00Behavior Brain,Brain: Relations,Social \&amp; anatomy histology,Brain: physiology,Cognition,Culture,Humans,Interpersonal <span class="authorEditorList"><a href="/author/Vogeley">Kai Vogeley</a>, and <a href="/author/Roepstorff">Andreas Roepstorff</a> </span><em>Trends in Cognitive Sciences</em> <em>13(12):511--6</em> (<em>December 2009</em>)Sun Mar 27 17:20:41 CEST 2011Trends in Cognitive Sciencesdec12511--6Contextualising culture and social cognition132009Behavior Brain,Brain: Relations,Social \& anatomy histology,Brain: physiology,Cognition,Culture,Humans,Interpersonal Cognitive neurosciencists have recently begun to study self-consiousness and intersubjectivity but have not yet taken into account adequately the influence of culture on these phenomena. Here, we argue against the na\"{\i}ve inclusion of 'culture' as an additional independent factor that can be empirically addressed adequately merely by considering mother tongue or nationality. Instead, we propose that culture needs to be considered as a dynamical system of individuals; that culture is in continous dialectic interaction and exchange with the individuals that constitute it; and that cultural classifications feed back into social practices and identity processes, hence exhibiting a 'looping effect'. These proposals have important implications for the development of cultural neuroscience.http://www.bibsonomy.org/bibtex/282ebe84f609c5b13a8ce76737895b947/harshvs20harshvs202011-03-11T19:51:02+01:00behavior message survey <span class="authorEditorList"><a href="/author/Morris">Katrina Panovich Meredith Ringel Morris</a> </span> (<em>2010</em>)Fri Mar 11 19:51:02 CET 2011What Do People Ask Their Social Networks, and Why? A Survey Study of Status Message Q&A Behavior2010behavior message survey