AlanP.Benson JenniferA.Lawrenson StephenH.Gilbert ArunV.Holden Quantifying Effects of Class I Anti-arrhythmic Drugs in Human Virtual Cardiac Tissues. Springer 5104 203-208 2008 G.Benson R.Olsson R.Pandey On the Decomposition of Runtime Support for Concurrent Programming Languages 86–94 1996 SCBenson HAPershadsingh CIHo AChittiboyina PDesai MPravenec NQi JWang MAAvery TWKurtz Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity. Hypertension 43 993-1002 2004 The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood pressure. In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been reported to cause the full-blown metabolic syndrome, and drugs that activate PPARgamma have proven to be effective agents for the prevention and treatment of insulin resistance and type 2 diabetes. Here we report that telmisartan, a structurally unique angiotensin II receptor antagonist used for the treatment of hypertension, can function as a partial agonist of PPARgamma; influence the expression of PPARgamma target genes involved in carbohydrate and lipid metabolism; and reduce glucose, insulin, and triglyceride levels in rats fed a high-fat, high-carbohydrate diet. None of the other commercially available angiotensin II receptor antagonists appeared to activate PPARgamma when tested at concentrations typically achieved in plasma with conventional oral dosing. In contrast to ordinary antihypertensive and antidiabetic agents, molecules that can simultaneously block the angiotensin II receptor and activate PPARgamma have the potential to treat both hemodynamic and biochemical features of the metabolic syndrome and could provide unique opportunities for the prevention and treatment of diabetes and cardiovascular disease in high-risk populations. StevenJ.Benson YinyuYe Algorithm 875: DSDP5 - software for semidefinite programming. ACM Trans. Math. Softw. 34 2008 BryanFord GodmarBack GregBenson JayLepreau AlbertLin OlinShivers The Flux OSKit: a substrate for kernel and language research ACM Press 38–51 1997 StevenC.Horii HowardN.Horii SeongK.Mun HaroldR.Benson RobertK.Zeman Environmental Designs for Reading from Imaging Workstations: Ergonomic and Architectural Features. J. Digital Imaging 16 124-131 2003 BensonS. Y.Lam AlanWee-ChungLiew DavidK.Smith HongYan A Regularized Clustering Algorithm Based on Calculus of Variations. Signal Processing Systems 50 281-292 2008 BettyAnnLevine SeongK.Mun HaroldR.Benson StevenC.Horii Assessment of the Integration of a HIS/RIS with a PACS. J. Digital Imaging 16 133-140 2003 SeongK.Mun SteveHorii HaroldR.Benson S.H.Lo DavidR.Haynor AlanSarrinen YongminKim JohnLoop MelvynGreberman RobertAllman Experience with Image Management Networks at Three Universities: Is the Cup Half-empty or Half-full? J. Digital Imaging 16 115-122 2003 AdamD.Todd J.Benson G.L.Peterson T.Franz M.Stevens RichardA.Raines Analysis of Tools for Detecting Rootkits and Hidden Processes. Springer 242 89-105 2007