Hinrichsen,RD Tran,JR A circadian clock regulates sensitivity to cadmium in Paramecium tetraurelia Cell Biol Toxicol 2010 The heavy metal cadmium is a dangerous environmental toxicant that can be lethal to humans and other organisms. This paper demonstrates that cadmium is lethal to the ciliated protozoan Paramecium tetraurelia and that a circadian clock modulates the sensitivity of the cells to cadmium. Various concentrations of cadmium were shown to increase the number of behavioral responses, decrease the swimming speed of cells, and generate large vacuole formation in cells prior to death. Cells were grown in either 12-h light/12-h dark or constant dark conditions exhibited a toxic response to 500 muM CdCl(2); the sensitivity of the response was found to vary with a 24-h periodicity. Cells were most sensitive to cadmium at circadian time 0 (CT0), while they were least sensitive in the early evening (CT12). This rhythm persisted even when the cells were grown in constant dark. The oscillation in cadmium sensitivity was shown to be temperature-compensated; cells grown at 18 degrees C and 28 degrees C had a similar 24-h oscillation. Finally, phase shifting experiments demonstrated a phase-dependent response to light. These data establish the criteria required for a circadian clock and demonstrate that P. tetraurelia possesses a circadian-influenced regulatory component of the cadmium toxic response. The Paramecium system is shown to be an excellent model system for the study of the effects of biological rhythms on heavy metal toxicity. Weihusen,Andreas Hinrichsen,Lisa Carus,Thomas Dammer,Rainer Rascher-Friesenhausen,Richard Kröger,Tim Peitgen,Heinz-Otto Preusser,Tobias Towards a Verified Simulation Model for Radiofrequency Ablations. Springer 6135 179-189 2010 Hinrichsen,Diederich Pritchard,AnthonyJ. Composite Systems with Uncertain Couplings of Fixed Structure: Scaled Riccati Equations and the Problem of Quadratic Stability. SIAM J. Control and Optimization 47 3037-3075 2009 Hinrichsen,VirginiaL. Kruskal,Benjamin O'Brien,MeganA. Lieu,TracyA. Platt,Richard Application of Information Technology: Using Electronic Medical Records to Enhance Detection and Reporting of Vaccine Adverse Events. JAMIA 14 731-735 2007 Hinrichsen,H. Non-equilibrium phase transitions Physica A 369 1–28 2006 These lecture notes give a basic introduction to the physics of phase transitions under non-equilibrium conditions. The notes start with a general introduction to non-equilibrium statistical mechanics followed by four parts. The first one discusses the universality class of directed percolation, which plays a similar role as the Ising model in equilibrium statistical physics. The second one gives an overview about other universality classes which have been of interest in recent years. The third part extends the scope to models with long-range interactions, including memory effects and the so-called L'evy flights. Finally, the fourth part is concerned with deposition–evaporation phenomena leading to wetting transitions out of equilibrium. Karow,Michael Hinrichsen,Diederich Pritchard,AnthonyJ. Interconnected Systems with Uncertain Couplings: Explicit Formulae for mu-Values, Spectral Value Sets, and Stability Radii. SIAM J. Control and Optimization 45 856-884 2006 Hinrichsen,Malte Entertainment & society. Audiences, trends and impacts. Zeitschrift für Medienpsychologie 16 36-37 2004 Kharitonov,VladimirL. Hinrichsen,D. Exponential estimates for time delay systems. Systems & Control Letters 53 395-405 2004 Voss,R. Hinrichsen,H.-H. Source of uncertainty in icthyoplankton surveys: modelling the influence of wind forcing and survey strategy on adundance estimates Journal of Marine Systems 43 87-103 2003 Antoni,Mickaël Hinrichsen,Haye Ruffo,Stefano On the microcanonical solution of a system of fully coupled particles Chaos,Solitons,& Fractals 13 393–399 2002 Dornic,Ivan Chaté,Hugues Chave,Jérôme Hinrichsen,Haye Critical Coarsening without Surface Tension: The Universality Class of the Voter Model Physical Review Letters American Physical Society 87 045701 2001 We show that the two-dimensional voter model, usually considered to be only a marginal coarsening system, represents a broad class of models for which phase ordering takes place without surface tension. We argue that voter-like growth is generically observed at order-disorder nonequilibrium transitions solely driven by interfacial noise between dynamically symmetric absorbing states. LaValle,StevenM. Hinrichsen,John Visibility-based pursuit-evasion: the case of curved environments. IEEE Transactions on Robotics 17 196-202 2001 Bouhtouri,A.El Hinrichsen,Diederich Pritchard,AnthonyJ. Stability radii of discrete-time stochastic systems with respect to blockdiagonal perturbations. Automatica 36 1033-1040 2000 Hinrichsen,Haye Non-equilibrium critical phenomena and phase transitions into absorbing states Adv.~Phys. 49 815–958 2000 This review addresses recent developments in non-equilibrium statistical physics. Focusing on phase transitions from fluctuating phases into absorbing states, the universality class of directed percolation is investigated in detail. The survey gives a general introduction to various lattice models of directed percolation and studies their scaling properties, field-theoretic aspects, numerical techniques, as well as possible experimental realizations. In addition, several examples of absorbing-state transitions which do not belong to the directed percolation universality class will be discussed. As a closely related technique, we investigate the concept of damage spreading. It is shown that this technique is ambiguous to some extent, making it impossible to define chaotic and regular phases in stochastic non-equilibrium systems. Finally, we discuss various classes of depinning transitions in models for interface growth which are related to phase transitions into absorbing states. Ritter,Gerd Hinrichsen,Holger Eveking,Hans Formal Verification of Descriptions with Distinct Order of Memory Operations. Springer 1742 308-321 1999 Ritter,Gerd Eveking,Hans Hinrichsen,Holger Formal Verification of Designs with Complex Control by Symbolic Simulation. Springer 1703 234-249 1999 Tokos,K.L.Schultz Hinrichsen,H.-H. W.,Zenk Merging and Migration of Two Meddies Journal of Physical Oceanography 24 2129-2141 1994 Lieberman,J.A. Ma,J. Alvir,J. Woerner,M. Degreef,G. Bilder,R.M. Ashtari,M. Bogerts,B. Mayerhoff,D.I. Geisler,S.H. Loebel,A. Levy,D.L. Hinrichsen,G. Szymanski,S. Chakos,M. Koreen,A. Borenstein,M. Kane,J.M. Prospective study of psychobiology in first-episode schizophrenia at Hillside Hospital Schizophrenia Bulletin 18 351-371 1992 Stammer,D. Hinrichsen,H.-H. K\"ase,R.H. Can Meddies Be Detected By Satellite Altimetry ? Journal of Geophysical Research 96 7005-7014 1991 K\"ase,R.H. Beckmann,A. Hinrichsen,H.-H. Observational Evidence of Salt Lens Formation in the Iberian Basin Journal of Geophysical Research 94 4905-4912 1989