The heavy metal cadmium is a dangerous environmental toxicant that can be lethal to humans and other organisms. This paper demonstrates that cadmium is lethal to the ciliated protozoan Paramecium tetraurelia and that a circadian clock modulates the sensitivity of the cells to cadmium. Various concentrations of cadmium were shown to increase the number of behavioral responses, decrease the swimming speed of cells, and generate large vacuole formation in cells prior to death. Cells were grown in either 12-h light/12-h dark or constant dark conditions exhibited a toxic response to 500 muM CdCl(2); the sensitivity of the response was found to vary with a 24-h periodicity. Cells were most sensitive to cadmium at circadian time 0 (CT0), while they were least sensitive in the early evening (CT12). This rhythm persisted even when the cells were grown in constant dark. The oscillation in cadmium sensitivity was shown to be temperature-compensated; cells grown at 18 degrees C and 28 degrees C had a similar 24-h oscillation. Finally, phase shifting experiments demonstrated a phase-dependent response to light. These data establish the criteria required for a circadian clock and demonstrate that P. tetraurelia possesses a circadian-influenced regulatory component of the cadmium toxic response. The Paramecium system is shown to be an excellent model system for the study of the effects of biological rhythms on heavy metal toxicity.

@article{Hinrichsen:2010:Cell-Biol-Toxicol:20108033, author = {Hinrichsen, R D and Tran, J R}, title = {A circadian clock regulates sensitivity to cadmium in Paramecium tetraurelia}, journal = {Cell Biol Toxicol}, year = {2010}, url = {http://www.ncbi.nlm.nih.gov/pubmed/20108033?dopt=Abstract}, doi = {10.1007/s10565-010-9150-x}, keywords = {crosstalk}, abstract = {The heavy metal cadmium is a dangerous environmental toxicant that can be lethal to humans and other organisms. This paper demonstrates that cadmium is lethal to the ciliated protozoan Paramecium tetraurelia and that a circadian clock modulates the sensitivity of the cells to cadmium. Various concentrations of cadmium were shown to increase the number of behavioral responses, decrease the swimming speed of cells, and generate large vacuole formation in cells prior to death. Cells were grown in either 12-h light/12-h dark or constant dark conditions exhibited a toxic response to 500 muM CdCl(2); the sensitivity of the response was found to vary with a 24-h periodicity. Cells were most sensitive to cadmium at circadian time 0 (CT0), while they were least sensitive in the early evening (CT12). This rhythm persisted even when the cells were grown in constant dark. The oscillation in cadmium sensitivity was shown to be temperature-compensated; cells grown at 18 degrees C and 28 degrees C had a similar 24-h oscillation. Finally, phase shifting experiments demonstrated a phase-dependent response to light. These data establish the criteria required for a circadian clock and demonstrate that P. tetraurelia possesses a circadian-influenced regulatory component of the cadmium toxic response. The Paramecium system is shown to be an excellent model system for the study of the effects of biological rhythms on heavy metal toxicity.} }

%0 = article %A = Hinrichsen, R D and Tran, J R %D = 2010 %T = A circadian clock regulates sensitivity to cadmium in Paramecium tetraurelia %U = http://www.ncbi.nlm.nih.gov/pubmed/20108033?dopt=Abstract

@inproceedings{conf/ipcai/WeihusenHCDRKPP10, author = {Weihusen, Andreas and Hinrichsen, Lisa and Carus, Thomas and Dammer, Rainer and Rascher-Friesenhausen, Richard and Kröger, Tim and Peitgen, Heinz-Otto and Preusser, Tobias}, title = {Towards a Verified Simulation Model for Radiofrequency Ablations.}, editor = {Navab, Nassir and Jannin, Pierre}, booktitle = {IPCAI}, series = {Lecture Notes in Computer Science}, publisher = {Springer}, year = {2010}, volume = {6135}, pages = {179-189}, url = {http://dblp.uni-trier.de/db/conf/ipcai/ipcai2010.html#WeihusenHCDRKPP10}, isbn = {978-3-642-13710-5}, keywords = {dblp} }

%0 = inproceedings %A = Weihusen, Andreas and Hinrichsen, Lisa and Carus, Thomas and Dammer, Rainer and Rascher-Friesenhausen, Richard and Kröger, Tim and Peitgen, Heinz-Otto and Preusser, Tobias %B = IPCAI %D = 2010 %I = Springer %T = Towards a Verified Simulation Model for Radiofrequency Ablations. %U = http://dblp.uni-trier.de/db/conf/ipcai/ipcai2010.html#WeihusenHCDRKPP10

@article{journals/siamco/HinrichsenP09, author = {Hinrichsen, Diederich and Pritchard, Anthony J.}, title = {Composite Systems with Uncertain Couplings of Fixed Structure: Scaled Riccati Equations and the Problem of Quadratic Stability.}, journal = {SIAM J. Control and Optimization}, year = {2009}, volume = {47}, number = {6}, pages = {3037-3075}, url = {http://dblp.uni-trier.de/db/journals/siamco/siamco47.html#HinrichsenP09}, keywords = {dblp} }

%0 = article %A = Hinrichsen, Diederich and Pritchard, Anthony J. %D = 2009 %T = Composite Systems with Uncertain Couplings of Fixed Structure: Scaled Riccati Equations and the Problem of Quadratic Stability. %U = http://dblp.uni-trier.de/db/journals/siamco/siamco47.html#HinrichsenP09

@article{journals/jamia/HinrichsenKOLP07, author = {Hinrichsen, Virginia L. and Kruskal, Benjamin and O'Brien, Megan A. and Lieu, Tracy A. and Platt, Richard}, title = {Application of Information Technology: Using Electronic Medical Records to Enhance Detection and Reporting of Vaccine Adverse Events.}, journal = {JAMIA}, year = {2007}, volume = {14}, number = {6}, pages = {731-735}, url = {http://dblp.uni-trier.de/db/journals/jamia/jamia14.html#HinrichsenKOLP07}, keywords = {dblp} }

%0 = article %A = Hinrichsen, Virginia L. and Kruskal, Benjamin and O'Brien, Megan A. and Lieu, Tracy A. and Platt, Richard %D = 2007 %T = Application of Information Technology: Using Electronic Medical Records to Enhance Detection and Reporting of Vaccine Adverse Events. %U = http://dblp.uni-trier.de/db/journals/jamia/jamia14.html#HinrichsenKOLP07

These lecture notes give a basic introduction to the physics of phase transitions under non-equilibrium conditions. The notes start with a general introduction to non-equilibrium statistical mechanics followed by four parts. The first one discusses the universality class of directed percolation, which plays a similar role as the Ising model in equilibrium statistical physics. The second one gives an overview about other universality classes which have been of interest in recent years. The third part extends the scope to models with long-range interactions, including memory effects and the so-called Lévy flights. Finally, the fourth part is concerned with deposition–evaporation phenomena leading to wetting transitions out of equilibrium.

@article{Hinrichsen2006, author = {Hinrichsen, H.}, title = {Non-equilibrium phase transitions}, journal = {Physica A}, year = {2006}, volume = {369}, number = {1}, pages = {1--28}, doi = {10.1016/j.physa.2006.04.007}, keywords = {critical-phenomena non-equilibrium percolation phase-transition}, abstract = {These lecture notes give a basic introduction to the physics of phase transitions under non-equilibrium conditions. The notes start with a general introduction to non-equilibrium statistical mechanics followed by four parts. The first one discusses the universality class of directed percolation, which plays a similar role as the Ising model in equilibrium statistical physics. The second one gives an overview about other universality classes which have been of interest in recent years. The third part extends the scope to models with long-range interactions, including memory effects and the so-called Lévy flights. Finally, the fourth part is concerned with deposition–evaporation phenomena leading to wetting transitions out of equilibrium.} }

%0 = article %A = Hinrichsen, H. %D = 2006 %T = Non-equilibrium phase transitions

@article{journals/siamco/KarowHP06, author = {Karow, Michael and Hinrichsen, Diederich and Pritchard, Anthony J.}, title = {Interconnected Systems with Uncertain Couplings: Explicit Formulae for mu-Values, Spectral Value Sets, and Stability Radii.}, journal = {SIAM J. Control and Optimization}, year = {2006}, volume = {45}, number = {3}, pages = {856-884}, url = {http://dblp.uni-trier.de/db/journals/siamco/siamco45.html#KarowHP06}, keywords = {dblp} }

%0 = article %A = Karow, Michael and Hinrichsen, Diederich and Pritchard, Anthony J. %D = 2006 %T = Interconnected Systems with Uncertain Couplings: Explicit Formulae for mu-Values, Spectral Value Sets, and Stability Radii. %U = http://dblp.uni-trier.de/db/journals/siamco/siamco45.html#KarowHP06

@article{journals/zmp/Hinrichsen04, author = {Hinrichsen, Malte}, title = {Entertainment & society. Audiences, trends and impacts.}, journal = {Zeitschrift für Medienpsychologie}, year = {2004}, volume = {16}, number = {1}, pages = {36-37}, url = {http://dblp.uni-trier.de/db/journals/zmp/zmp16.html#Hinrichsen04}, keywords = {dblp} }

%0 = article %A = Hinrichsen, Malte %D = 2004 %T = Entertainment & society. Audiences, trends and impacts. %U = http://dblp.uni-trier.de/db/journals/zmp/zmp16.html#Hinrichsen04

@article{journals/scl/KharitonovH04, author = {Kharitonov, Vladimir L. and Hinrichsen, D.}, title = {Exponential estimates for time delay systems.}, journal = {Systems & Control Letters}, year = {2004}, volume = {53}, number = {5}, pages = {395-405}, url = {http://dblp.uni-trier.de/db/journals/scl/scl53.html#KharitonovH04}, keywords = {dblp} }

%0 = article %A = Kharitonov, Vladimir L. and Hinrichsen, D. %D = 2004 %T = Exponential estimates for time delay systems. %U = http://dblp.uni-trier.de/db/journals/scl/scl53.html#KharitonovH04

@article{voss_hinrichsen_2003_jms, author = {Voss, R. and Hinrichsen, H.-H.}, title = {Source of uncertainty in icthyoplankton surveys: modelling

the influence of wind forcing and survey strategy on

adundance estimates}, journal = {Journal of Marine Systems}, year = {2003}, volume = {43}, pages = {87-103}, url = {/publ/BIB_CDs/BIB_040317_1200/voss_hinrichsen_2003_JMS.pdf}, keywords = {imported} }

%0 = article %A = Voss, R. and Hinrichsen, H.-H. %D = 2003 %T = Source of uncertainty in icthyoplankton surveys: modelling

the influence of wind forcing and survey strategy on

adundance estimates %U = /publ/BIB_CDs/BIB_040317_1200/voss_hinrichsen_2003_JMS.pdf

@article{Antoni2002, author = {Antoni, Mickaël and Hinrichsen, Haye and Ruffo, Stefano}, title = {On the microcanonical solution of a system of fully coupled particles}, journal = {Chaos,Solitons,& Fractals}, year = {2002}, volume = {13}, number = {3}, pages = {393--399}, url = {http://www.sciencedirect.com/science/article/B6TJ4-440BP16-3/1/e610a85bb6c9775aab97af2b168bf8a3}, keywords = {imported} }

%0 = article %A = Antoni, Mickaël and Hinrichsen, Haye and Ruffo, Stefano %D = 2002 %T = On the microcanonical solution of a system of fully coupled particles %U = http://www.sciencedirect.com/science/article/B6TJ4-440BP16-3/1/e610a85bb6c9775aab97af2b168bf8a3

We show that the two-dimensional voter model, usually considered to be only a marginal coarsening system, represents a broad class of models for which phase ordering takes place without surface tension. We argue that voter-like growth is generically observed at order-disorder nonequilibrium transitions solely driven by interfacial noise between dynamically symmetric absorbing states.

@article{Dornic2001, author = {Dornic, Ivan and Chaté, Hugues and Chave, Jérôme and Hinrichsen, Haye}, title = {Critical Coarsening without Surface Tension: The Universality Class of the Voter Model}, journal = {Physical Review Letters}, publisher = {American Physical Society}, year = {2001}, volume = {87}, number = {4}, pages = {045701}, doi = {10.1103/PhysRevLett.87.045701}, keywords = {critical-phenomena criticality interfacial-noise non-equilibrium universality voter-model}, abstract = {We show that the two-dimensional voter model, usually considered to be only a marginal coarsening system, represents a broad class of models for which phase ordering takes place without surface tension. We argue that voter-like growth is generically observed at order-disorder nonequilibrium transitions solely driven by interfacial noise between dynamically symmetric absorbing states.} }

%0 = article %A = Dornic, Ivan and Chaté, Hugues and Chave, Jérôme and Hinrichsen, Haye %D = 2001 %I = American Physical Society %T = Critical Coarsening without Surface Tension: The Universality Class of the Voter Model

@article{journals/trob/LaValleH01, author = {LaValle, Steven M. and Hinrichsen, John}, title = {Visibility-based pursuit-evasion: the case of curved environments.}, journal = {IEEE Transactions on Robotics}, year = {2001}, volume = {17}, number = {2}, pages = {196-202}, url = {http://dblp.uni-trier.de/db/journals/trob/trob17.html#LaValleH01}, keywords = {dblp} }

%0 = article %A = LaValle, Steven M. and Hinrichsen, John %D = 2001 %T = Visibility-based pursuit-evasion: the case of curved environments. %U = http://dblp.uni-trier.de/db/journals/trob/trob17.html#LaValleH01

@article{journals/automatica/BouhtouriHP00, author = {Bouhtouri, A. El and Hinrichsen, Diederich and Pritchard, Anthony J.}, title = {Stability radii of discrete-time stochastic systems with respect to blockdiagonal perturbations.}, journal = {Automatica}, year = {2000}, volume = {36}, number = {7}, pages = {1033-1040}, url = {http://dblp.uni-trier.de/db/journals/automatica/automatica36.html#BouhtouriHP00}, keywords = {dblp} }

%0 = article %A = Bouhtouri, A. El and Hinrichsen, Diederich and Pritchard, Anthony J. %D = 2000 %T = Stability radii of discrete-time stochastic systems with respect to blockdiagonal perturbations. %U = http://dblp.uni-trier.de/db/journals/automatica/automatica36.html#BouhtouriHP00

This review addresses recent developments in non-equilibrium statistical physics. Focusing on phase transitions from fluctuating phases into absorbing states, the universality class of directed percolation is investigated in detail. The survey gives a general introduction to various lattice models of directed percolation and studies their scaling properties, field-theoretic aspects, numerical techniques, as well as possible experimental realizations. In addition, several examples of absorbing-state transitions which do not belong to the directed percolation universality class will be discussed. As a closely related technique, we investigate the concept of damage spreading. It is shown that this technique is ambiguous to some extent, making it impossible to define chaotic and regular phases in stochastic non-equilibrium systems. Finally, we discuss various classes of depinning transitions in models for interface growth which are related to phase transitions into absorbing states.

@article{HIN00, author = {Hinrichsen, Haye}, title = {Non-equilibrium critical phenomena and phase transitions into absorbing states}, journal = {Adv.~Phys.}, year = {2000}, volume = {49}, number = {7}, pages = {815--958}, doi = {10.1080/00018730050198152}, keywords = {imported}, abstract = {This review addresses recent developments in non-equilibrium statistical physics. Focusing on phase transitions from fluctuating phases into absorbing states, the universality class of directed percolation is investigated in detail. The survey gives a general introduction to various lattice models of directed percolation and studies their scaling properties, field-theoretic aspects, numerical techniques, as well as possible experimental realizations. In addition, several examples of absorbing-state transitions which do not belong to the directed percolation universality class will be discussed. As a closely related technique, we investigate the concept of damage spreading. It is shown that this technique is ambiguous to some extent, making it impossible to define chaotic and regular phases in stochastic non-equilibrium systems. Finally, we discuss various classes of depinning transitions in models for interface growth which are related to phase transitions into absorbing states. } }

%0 = article %A = Hinrichsen, Haye %D = 2000 %T = Non-equilibrium critical phenomena and phase transitions into absorbing states

@inproceedings{conf/asian/RitterHE99, author = {Ritter, Gerd and Hinrichsen, Holger and Eveking, Hans}, title = {Formal Verification of Descriptions with Distinct Order of Memory Operations.}, editor = {Thiagarajan, P. S. and Yap, Roland H. C.}, booktitle = {ASIAN}, series = {Lecture Notes in Computer Science}, publisher = {Springer}, year = {1999}, volume = {1742}, pages = {308-321}, url = {http://dblp.uni-trier.de/db/conf/asian/asian99.html#RitterHE99}, isbn = {3-540-66856-X}, keywords = {dblp} }

%0 = inproceedings %A = Ritter, Gerd and Hinrichsen, Holger and Eveking, Hans %B = ASIAN %D = 1999 %I = Springer %T = Formal Verification of Descriptions with Distinct Order of Memory Operations. %U = http://dblp.uni-trier.de/db/conf/asian/asian99.html#RitterHE99

@inproceedings{conf/charme/RitterEH99, author = {Ritter, Gerd and Eveking, Hans and Hinrichsen, Holger}, title = {Formal Verification of Designs with Complex Control by Symbolic Simulation.}, editor = {Pierre, Laurence and Kropf, Thomas}, booktitle = {CHARME}, series = {Lecture Notes in Computer Science}, publisher = {Springer}, year = {1999}, volume = {1703}, pages = {234-249}, url = {http://dblp.uni-trier.de/db/conf/charme/charme1999.html#RitterEH99}, isbn = {3-540-66559-5}, keywords = {dblp} }

%0 = inproceedings %A = Ritter, Gerd and Eveking, Hans and Hinrichsen, Holger %B = CHARME %D = 1999 %I = Springer %T = Formal Verification of Designs with Complex Control by Symbolic Simulation. %U = http://dblp.uni-trier.de/db/conf/charme/charme1999.html#RitterEH99

@article{schultz_tokos_etal_1994, author = {Tokos, K.L. Schultz and Hinrichsen, H.-H. and W., Zenk}, title = {Merging and Migration of Two Meddies}, journal = {Journal of Physical Oceanography}, year = {1994}, volume = {24}, number = {10}, pages = {2129-2141}, keywords = {imported} }

%0 = article %A = Tokos, K.L. Schultz and Hinrichsen, H.-H. and W., Zenk %D = 1994 %T = Merging and Migration of Two Meddies

@article{LiebermanMaAlvirEtAl92, author = {Lieberman, J. A. and Ma, J. and Alvir, J. and Woerner, M. and Degreef, G. and Bilder, R. M. and Ashtari, M. and Bogerts, B. and Mayerhoff, D. I. and Geisler, S. H. and Loebel, A. and Levy, D. L. and Hinrichsen, G. and Szymanski, S. and Chakos, M. and Koreen, A. and Borenstein, M. and Kane, J. M.}, title = {Prospective study of psychobiology in first-episode schizophrenia

at Hillside Hospital}, journal = {Schizophrenia Bulletin}, year = {1992}, volume = {18}, number = {3}, pages = {351-371}, keywords = {CCP JRR,} }

%0 = article %A = Lieberman, J. A. and Ma, J. and Alvir, J. and Woerner, M. and Degreef, G. and Bilder, R. M. and Ashtari, M. and Bogerts, B. and Mayerhoff, D. I. and Geisler, S. H. and Loebel, A. and Levy, D. L. and Hinrichsen, G. and Szymanski, S. and Chakos, M. and Koreen, A. and Borenstein, M. and Kane, J. M. %D = 1992 %T = Prospective study of psychobiology in first-episode schizophrenia

at Hillside Hospital

@article{stammer_etal_1991_jgr, author = {Stammer, D. and Hinrichsen, H.-H. and Käse, R.H.}, title = {Can Meddies Be Detected By Satellite Altimetry ?}, journal = {Journal of Geophysical Research}, year = {1991}, volume = {96}, number = {C4}, pages = {7005-7014}, keywords = {imported} }

%0 = article %A = Stammer, D. and Hinrichsen, H.-H. and Käse, R.H. %D = 1991 %T = Can Meddies Be Detected By Satellite Altimetry ?

@article{kase_etal_1989, author = {Käse, R.H. and Beckmann, A. and Hinrichsen, H.-H.}, title = {Observational Evidence of Salt Lens Formation in the

Iberian Basin}, journal = {Journal of Geophysical Research}, year = {1989}, volume = {94}, number = {C4}, pages = {4905-4912}, keywords = {imported} }

%0 = article %A = Käse, R.H. and Beckmann, A. and Hinrichsen, H.-H. %D = 1989 %T = Observational Evidence of Salt Lens Formation in the

Iberian Basin