BibSonomy publications for /author/ArnoldMon Feb 13 00:00:00 CET 2012AI Magazine3119-127Reports of the AAAI 2011 Spring Symposia.322011dblp Mon Feb 13 00:00:00 CET 2012AAAI Spring Symposium: Modeling Complex Adaptive Systems as if They Were Voting Processesconf/aaaiss/2011-8Voting Theory, Data Fusion, and Explanations of Social Behavior.2011dblp Mon Feb 13 00:00:00 CET 2012AAAI Spring Symposium: Modeling Complex Adaptive Systems as if They Were Voting Processesconf/aaaiss/2011-8Organizing Committee.2011dblp Mon Feb 13 00:00:00 CET 2012AAAI Spring Symposium: Modeling Complex Adaptive Systems as if They Were Voting Processesconf/aaaiss/2011-8Preface.2011dblp Mon Feb 13 00:00:00 CET 2012WPESconf/wpes/200433-34Privacy issues in an electronic voting machine.2004dblp Thu Feb 09 00:00:00 CET 2012ITCconf/itc/1990698-705Experimental evaluation of concurrent fault simulation algorithms on scalable, hierarchically defined test cases.1990dblp Wed Feb 08 20:32:00 CET 2012New Brunswick, N.J.Political corruption : new perspectives in comparative analysis1989theorien politik patronage modernisierung korruption komparatistik geschichte Wed Feb 08 04:16:14 CET 2012PLoS One1e29949Discovery of T cell antigens by high-throughput screening of synthetic minigene libraries.72012antigens bcells discovery gene-expression high throughput tlymphocytes The identification of novel T cell antigens is central to basic and translational research in autoimmunity, tumor immunology, transplant immunology, and vaccine design for infectious disease. However, current methods for T cell antigen discovery are low throughput, and fail to explore a wide range of potential antigen-receptor interactions. To overcome these limitations, we developed a method in which programmable microarrays are used to cost-effectively synthesize complex libraries of thousands of minigenes that collectively encode the content of hundreds of candidate protein targets. Minigene-derived mRNA are transfected into autologous antigen presenting cells and used to challenge complex populations of purified peripheral blood CD8+ T cells in multiplex, parallel ELISPOT assays. In this proof-of-concept study, we apply synthetic minigene screening to identify two novel pancreatic islet autoantigens targeted in a patient with Type I Diabetes. To our knowledge, this is the first successful screen of a highly complex, synthetic minigene library for identification of a T cell antigen. In principle, responses against the full protein complement of any tissue or pathogen can be assayed by this approach, suggesting that further optimization of synthetic libraries holds promise for high throughput antigen discovery.Wed Feb 08 00:00:00 CET 2012ACM Trans. Softw. Eng. Methodol.12QVM: An Efficient Runtime for Detecting Defects in Deployed Systems.212011dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1997760-767HABIST: Histogram-Based Analog Built-In Self-Test.1997dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1997127-135Experiences with Implementation of IDDQ Test for Identification and Automotive Products.1997dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1993552-555Timing Analyzer for Embedded Testing.1993dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1993764-772Test Features of the HP PA7100LC Processor.1993dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1992854-859Test/Agent: CAD-integrated Automatic Generation of Test Programs.1992dblp Wed Feb 08 00:00:00 CET 2012ITCconf/itc/1991916-925Low Overhead Built-In Testable Error Detection and Correction with Excellent Fault Coverage.1991dblp Tue Feb 07 00:00:00 CET 2012IEEE Trans. Systems Science and Cybernetics4278-284Automatic Analysis of Sleep Electroencephalograms by Hybrid Computation.51969dblp Tue Feb 07 00:00:00 CET 2012J. Comput. Science2138-143Towards a petascale tree code: Scaling and efficiency of the PEPC library.22011dblp Tue Feb 07 00:00:00 CET 2012ITCconf/itc/20059Evaluating ATE-equipment for volume diagnosis.2005dblp Mon Feb 06 00:00:00 CET 2012Computer Physics Communications4880-889A massively parallel, multi-disciplinary Barnes-Hut tree code for extreme-scale N-body simulations.1832012dblp Mon Feb 06 00:00:00 CET 2012Multiscale Modeling & Simulation41624-1645Diffusion of Polarized Light.92011dblp