BibSonomy publications for /author/KnuthFri Feb 05 11:28:39 CET 2010Pharm.Res.4499-511Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report222005trends toxicity standards of methods as analysis Trials Topic Results Research Reproducibility Pharmaceutical Markers Clinical Chemistry Biological Assay Biomarkers are increasingly used in drug development to aid scientific and clinical decisions regarding the progress of candidate and marketed therapeutics. Biomarkers can improve the understanding of diseases as well as therapeutic and off-target effects of drugs. Early implementation of biomarker strategies thus promises to reduce costs and time-to-market as drugs proceed through increasingly costly and complex clinical development programs. The 2003 American Association of Pharmaceutical Sciences/Clinical Ligand Assay Society Biomarkers Workshop (Salt Lake City, UT, USA, October 24-25, 2003) addressed key issues in biomarker research, with an emphasis on the validation and implementation of biochemical biomarker assays, covering from preclinical discovery of efficacy and toxicity biomarkers through clinical and postmarketing implementation. This summary report of the workshop focuses on the major issues discussed during presentations and open forums and noted consensus achieved amonFri Feb 05 11:28:39 CET 2010Pharm.Res.4499-511Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report222005trends toxicity standards of methods as analysis Trials Topic Results Research Reproducibility Pharmaceutical Markers Clinical Chemistry Biological Assay Biomarkers are increasingly used in drug development to aid scientific and clinical decisions regarding the progress of candidate and marketed therapeutics. Biomarkers can improve the understanding of diseases as well as therapeutic and off-target effects of drugs. Early implementation of biomarker strategies thus promises to reduce costs and time-to-market as drugs proceed through increasingly costly and complex clinical development programs. The 2003 American Association of Pharmaceutical Sciences/Clinical Ligand Assay Society Biomarkers Workshop (Salt Lake City, UT, USA, October 24-25, 2003) addressed key issues in biomarker research, with an emphasis on the validation and implementation of biochemical biomarker assays, covering from preclinical discovery of efficacy and toxicity biomarkers through clinical and postmarketing implementation. This summary report of the workshop focuses on the major issues discussed during presentations and open forums and noted consensus achieved amonTue Feb 02 12:55:45 CET 2010Axioms and Hulls1992regal:68 handbib Mon Jan 25 00:00:00 CET 2010SIGACT News43-13Robert W Floyd, In Memoriam.342003dblp Thu Jan 07 09:09:32 CET 2010The Computer Journal297--111Literate Programming271984literate_programming Mon Dec 14 10:58:50 CET 2009Upper Saddle River,NJ, USA2ndConcrete Mathematics: A foundation for computer science1994imported Wed Dec 09 17:59:08 CET 2009Literate Programming1992imported Mon Nov 23 13:25:47 CET 2009Softw., Pract. 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