BibSonomy publications for /author/LocherMon Feb 06 09:03:37 CET 2012Molecular Nutrition & Food Research111546--1555Flavan-3-ol C-glycosides – Preparation and model experiments mimicking their human intestinal transit542010ihasslauer In order to study the human intestinal transit of flavan-3-ol C-glycosides, several C-glycosyl derivatives were prepared by non-enzymatic reaction of (+)-catechin with α-D-glucose, α-D-galactose and α-D-rhamnose, respectively. In contrast to literature data, we propose that the reaction mechanism proceeds in analogy to the rearrangement of flavan-3-ols during epimerization under alkaline conditions. Four of the 12 synthesized flavan-3-ol C-glycosides were incubated under aerobic conditions at 37°C using saliva (2 min) and simulated gastric juice (3 h). To simulate human intestine, the C-glycosides were also incubated under anaerobic conditions at 37°C both in human ileostomy fluid (10 h) and colostomy fluid (24 h), respectively. The flavan-3-ol C-glycosides under study, i.e. (+)-epicatechin 8-C-β-D-glucopyranoside (1a), (+)-epicatechin 6-C-β-D-glucopyranoside (1d), (+)-catechin 6-C-β-D-galactopyranoside (2b), (+)-catechin 6-C-β-D-rhamnopyranoside (3b) were analyzed in the incubation samples by HPLC-DAD and HPLC-DAD-MS/MS. They were found to be stable in the course of incubation in saliva, simulated gastric juice and ileostomy fluid and underwent degradation in colostomy fluid. While the 6-C-β-D-glucopyranoside 1d was completely metabolized between 2 and 4 h, decomposition of the 6-C-β-D-galactopyranoside 2b reached only 16±2% within 4 h of incubation. Linear degradation rates of 1d and 2b in colostomy fluid differed significantly. As microbial metabolism of flavan-3-ols is known not to be influenced by the stereochemistry of the aglycon, varying degradation rates are ascribed to the effect of the sugar moiety. Based on these results we assume that flavan-3-ol C-glycosides pass through the upper gastrointestinal tract (oral cavity, stomach and small intestine) unmodified and are then metabolized by the colonic microflora.Mon Dec 05 00:00:00 CET 2011CoRROptimal Gradient Clock Synchronization in Dynamic Networksabs/1005.28942010dblp Wed Nov 23 00:00:00 CET 2011ECISconf/ecis/20061232-1243The CIO - hype, science and reality.2006dblp Wed Nov 23 00:00:00 CET 2011ECISconf/ecis/20051561-1572Methodologies for Evaluating Information Security Investments - What Basel II Can Change in the Financial Industry.2005dblp Wed Oct 19 00:00:00 CEST 2011Theory Comput. Syst.4781-816Gradient Clock Synchronization in Dynamic Networks.492011dblp Wed Oct 19 00:00:00 CEST 2011FOCSconf/focs/2008509-518Clock Synchronization with Bounded Global and Local Skew.2008dblp Wed Oct 05 16:57:45 CEST 2011Tenerife, SpainProceedings of the 5th European Semantic Web Conference (ESWC 2008)478-492Adding Data Mining Support to SPARQL Via Statistical Relational Learning Methods.50212008mining ontology Wed Sep 07 00:00:00 CEST 2011Fundam. Inform.4383-403eDonkey & eMule's Kad: Measurements & Attacks.1092011dblp Wed Jul 06 00:00:00 CEST 2011CoopIS/DOA/ODBASEconf/coopis/20031051-1062Lecture Notes in Computer ScienceMonitoring the Distributed Virtual Orchestra with a CORBA Based Object Oriented Real-Time Data Distribution Service.28882003dblp Fri Jul 01 00:00:00 CEST 2011INFOCOMconf/infocom/2011954-962Hidden communication in P2P networks Steganographic handshake and broadcast.2011dblp Thu Jun 09 00:00:00 CEST 2011SPAAconf/spaa/2011299-308Finding heavy distinct hitters in data streams.2011dblp Tue May 31 00:00:00 CEST 2011GI Jahrestagung (1)conf/gi/2003-1280-285LNIIntegration von operationellen Risikoeffekten in das Controlling von strategischen IV-Investitionen bei Kreditinstituten.342003dblp Tue May 24 00:00:00 CEST 2011Computing4359-375An Algorithm for Locating All Zeros of a Real Polynomial.541995dblp Thu Apr 28 00:00:00 CEST 2011I-VIII, 1-401Mathematik für InformatikerNumerische Mathematik für Informatiker (2. Aufl.).1993dblp Wed Mar 16 00:00:00 CET 2011INTERSPEECHconf/interspeech/2003Speech recognition over bluetooth wireless channels.2003dblp Tue Aug 10 00:00:00 CEST 2010PODCconf/podc/2010430-439Optimal gradient clock synchronization in dynamic networks.2010dblp Wed Jul 21 16:04:02 CEST 2010ICDCNconf/icdcn/2010195-206Lecture Notes in Computer SciencePoisoning the Kad Network.59352010dblp Thu Feb 18 00:00:00 CET 2010J. ACM2Tight bounds for clock synchronization.572010dblp Tue Dec 15 00:00:00 CET 2009SOFSEMconf/sofsem/201061-70Lecture Notes in Computer ScienceClock Synchronization: Open Problems in Theory and Practice.59012010dblp Fri Aug 21 09:55:59 CEST 2009Düsseldorf1Baurechtliche SchriftenBauherrenmodelle in zivil- und steuerrechtlicher Sicht1982Sachenrecht Steuerrecht