We apply a simulational proxy of the -value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding “reactions” of two small lattice G polymers with different native geometries. Our findings show that for the more complex native fold (i.e., the one that is rich in nonlocal, long-range bonds), mutation of the residues that form the folding nucleus leads to a considerably larger increase in the folding time than the corresponding mutati...
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Innovative. Technically superior. Creative. Reliable. These are words researchers use to describe Pierce, a pioneer and leader in many research disciplines including protein chemistry, sample handling, immunology and chromatography.
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Mitogen-activated protein kinase p38 is a serin/threonine kinase originally isolated from lipopolysaccharide stimulated monocytes. There are 4 isoforms; p38-a activation has been most widely studied for inflammation...
T. Malinauskas, T. Peer, B. Bishop, T. Mueller, and C. Siebold. Proc Natl Acad Sci U S A, 117 (27):
15620-15631(2020)Malinauskas, Tomas
Peer, Tina V
Bishop, Benjamin
Mueller, Thomas D
Siebold, Christian
eng
26752/CRUK_/Cancer Research UK/United Kingdom
C20724/A26752/CRUK_/Cancer Research UK/United Kingdom
WT_/Wellcome Trust/United Kingdom
203852/Z/16/2/WT_/Wellcome Trust/United Kingdom
14414/CRUK_/Cancer Research UK/United Kingdom
C20724/A14414/CRUK_/Cancer Research UK/United Kingdom
Research Support, Non-U.S. Gov't
2020/06/25
Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15620-15631. doi: 10.1073/pnas.2000561117. Epub 2020 Jun 23..
D. Vaz, J. Rodrigues, N. Loureiro-Ferreira, T. Muller, W. Sebald, C. Redfield, and R. Brito. Proteins, 92 (2):
219-235(2024)Vaz, Daniela C
Rodrigues, J Rui
Loureiro-Ferreira, Nuno
Muller, Thomas D
Sebald, Walter
Redfield, Christina
Brito, Rui M M
eng
European Regional Development Fund/
UIDB/00313/2020/Fundacao para a Ciencia e a Tecnologia/
UIDP/00313/2020/Fundacao para a Ciencia e a Tecnologia/
CENTRO-07-CT62-FEDER-002012/FEDER/COMPETE/
RECI/QEQ-QFI/0168/2012/FEDER/COMPETE/
Rede Nacional de Ressonancia Magnetica Nuclear (RNRMN/PTNMR)/
LA/P/0045/2020/ALiCE/
UIDP/50020/2020/LSRE-LCM/
UIDB/50020/2020/LSRE-LCM/
FCT/MCTES (PIDDAC)/
2023/10/10
Proteins. 2024 Feb;92(2):219-235. doi: 10.1002/prot.26611. Epub 2023 Oct 10..