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Computing normalised prediction distribution errors to evaluate nonlinear mixed-effect models: The npde add-on package for R
E. Comets, K. Brendel, and F. Mentre COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE 90(2):154-166 (2008)
to DESIGNS NONMEM P-VALUES POPULATION evaluation mixed-effects model nonlinear npde pharmacodynamics pharmacokinetics population by hruehs on Feb 4, 2010, 4:31 PM
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Comparison of stepwise covariate model building strategies in population pharmacokinetic-pharmacodynamic analysis
Ulrika Wählby, E. Niclas Jonsson, and Mats O. Karlsson AAPS pharmSci 4(4):E27 (2002)
to Bias Models, Pharmacokinetics Predictive Selection Statistical Tests Value of by hruehs on Feb 4, 2010, 4:31 PM
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The lasso--a novel method for predictive covariate model building in nonlinear mixed effects models
Jakob Ribbing, Joakim Nyberg, Ola Caster, and E. Niclas Jonsson Journal of Pharmacokinetics and Pharmacodynamics 34(4):485-517 (2007)
to Agentspharmacokinetics Algorithms Analysis Chlormethiazolepharmacokinetics Computer Dynamics Humans Linear Models Models, Neuroprotective Nonlinear Pharmacokinetics Regression Simulation Statistical Strokedrug therapy by hruehs on Feb 4, 2010, 4:31 PM
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Models for time-varying covariates in population pharmacokinetic-pharmacodynamic analysis
Ulrika Wählby, Alison H. Thomson, Peter A. Milligan, and Mats O. Karlsson British Journal of Clinical Pharmacology 58(4):367-377 (2004)
to Analysis Chemical Factors Gentamicinspharmacokineticspharmacology Humans Models, Pefloxacinpharmacokineticspharmacology Pharmacokinetics Pharmacology Pyrimidinespharmacokineticspharmacology Regression Time Triazolespharmacokineticspharmacology by hruehs on Feb 4, 2010, 4:31 PM
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Mechanism-based concepts of size and maturity in pharmacokinetics
B. J. Anderson, and N. H. G. Holford Annual review of pharmacology and toxicology (2008)
to & Adolescent Adult Age Biological Body Child Child, Compositionphysiology Dose-Response Drug Factors Humans Infant Infant, Models, Newborn Pharmaceutical Pharmacokinetics Preparationsadministration Preschool Relationship, Sizephysiology Weightphysiology dosage by hruehs on Feb 4, 2010, 4:31 PM
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Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide
K. Brendel, E. Comets, C. Laffont, C. Laveille, and F. Mentre PHARMACEUTICAL RESEARCH 23(9):2036-2049 (2006)
to DEVELOPMENT DRUG MODIFIED PERFORMANCE PREDICTIVE RELEASE Simulation VALIDATION check evaluation external metrics model pharmacokinetics population posterior predictive validation by hruehs on Feb 4, 2010, 4:31 PM
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