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• Harmonization of strategies for the validation of quantitative analytical procedures. A SFSTP proposal--part III
  P. Hubert and J. J. Nguyen-Huu and B. Boulanger and E. Chapuzet and N. Cohen and P. A. Compagnon and W. Dewe and M. Feinberg and M. Laurentie and N. Mercier and G. Muzard and L. Valat and E. Rozet J.Pharm.Biomed.Anal.45(1):82-96(2007)
  to & Analytical Calibration Chemistry Clinical France Laboratories Laboratory Medical Pharmaceutical Reference Reproducibility Research Results Societies Standards Techniques data methods numerical of standards statistics by kanefendt on Feb 5, 2010, 11:28 AM
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• Sunitinib induced hypertension, thrombotic microangiopathy and reversible posterior leukencephalopathy syndrome
  E. Kapiteijn and A. Brand and J. Kroep and H. Gelderblom Ann.Oncol.18(10):1745-1747(2007)
  to & A Aged Agents Antineoplastic Endothelial Factor Female Growth Humans Hypertension Indoles Middle Neurotoxicity Purpura Pyrroles Receptor-2 Syndromes Thrombocytopenic Thrombotic Vascular adverse antagonists chemically effects etiology induced inhibitors by kanefendt on Feb 5, 2010, 11:28 AM
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• Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization
  D. Fukumura and R. K. Jain Microvasc.Res.74(2-3):72-84(2007)
  to & Angiogenesis Animals Blood Endothelial Factors Growth Humans Inhibitors Laboratories Neoplasms Neovascularization Pathologic Research Vascular Vessels antagonists blood cells drug inhibitors pathology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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• Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
  N. Henke and R. Schmidt-Ullrich and R. Dechend and J. K. Park and F. Qadri and M. Wellner and M. Obst and V. Gross and R. Dietz and F. C. Luft and C. Scheidereit and D. N. Muller Circ.Res.101(3):268-276(2007)
  to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Sunitinib efficacy against advanced renal cell carcinoma
  R. J. Motzer and M. D. Michaelson and J. Rosenberg and R. M. Bukowski and B. D. Curti and D. J. George and G. R. Hudes and B. G. Redman and K. A. Margolin and G. Wilding J.Urol.178(5):1883-1887(2007)
  to & Administration Adult Aged Agents Antineoplastic Carcinoma Cell Disease Disease-Free Female Follow-Up Humans Indoles Kidney Laboratories Male Method Middle Neoplasm Neoplasms Oral Outcome Progression Pyrroles Rate Renal Research Retrospective Single-Blind Staging States Studies Survival Treatment Tyrosine United administration dosage drug epidemiology methods mortality pathology response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
  P. Laakkonen and M. Waltari and T. Holopainen and T. Takahashi and B. Pytowski and P. Steiner and D. Hicklin and K. Persaud and J. R. Tonra and L. Witte and K. Alitalo Cancer Res.67(2):593-599(2007)
  to & Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
  T. F. Chu and M. A. Rupnick and R. Kerkela and S. M. Dallabrida and D. Zurakowski and L. Nguyen and K. Woulfe and E. Pravda and F. Cassiola and J. Desai and S. George and J. A. Morgan and D. M. Harris and N. S. Ismail and J. H. Chen and F. J. Schoen and A. D. van den Abbeele and G. D. Demetri and T. Force and M. H. Chen Lancet370(9604):2011-2019(2007)
  to & Aged Agents Animals Antineoplastic Arteries Artery Blood Carcinoma Coronary Disease Failure Female Gastrointestinal Heart Humans Hypertension Indoles Kinase Kinases Male Mice Middle Multicenter Pressure Protein-Tyrosine Pyrroles Rats Research Retrospective Safety Stroke Stromal Studies Topic Tumors Tyrosine Volume adverse antagonists as blood chemically drug effects induced inhibitors methods therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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• Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
  F. Cappuzzo and L. Toschi and G. Finocchiaro and C. Ligorio and A. Santoro Int.J.Biol.Markers22(1 Suppl 4):S10-S23(2007)
  to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other person on Feb 5, 2010, 11:28 AM
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• Severe cardiomyopathy in a patient with renal cell carcinoma after treatment with the novel tyrosine kinase inhibitor sunitinib
  E. Chorianopoulos and D. Jager and H. A. Katus and N. Frey Clin.Res.Cardiol.96(11):829-830(2007)
  to & Aged Agents Angiogenesis Antineoplastic Carcinoma Cardiomyopathies Cell Dysfunction Echocardiography Female Humans Illness Index Indoles Inhibitors Kidney Kinase Kinases Left Neoplasms Protein-Tyrosine Pyrroles Renal Severity Tyrosine Ventricular adverse antagonists chemically contraindications drug effects induced inhibitors of therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Appropriate calibration curve fitting in ligand binding assays
  J. W. Findlay and R. F. Dillard AAPS.J.9(2):E260-E267(2007)
  to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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• Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
  T. Force and D. S. Krause and R. A. van Etten Nat.Rev.Cancer7(5):332-344(2007)
  to & Adaptor Antibodies Benzenesulfonates Biological Delivery Diseases Drug Enzyme Heart Human Humans Indoles Inhibitors Kinase Kinases Models Monoclonal Mutation Neoplasms Protein Protein-Tyrosine Proteins Proto-Oncogene Pyridines Pyrroles Quinazolines Research Signal Systems Transducing Tyrosine adverse antagonists c-abl cells chemically development drug effects growth induced inhibitors physiology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
  J. M. Ebos and C. R. Lee and J. G. Christensen and A. J. Mutsaers and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A104(43):17069-17074(2007)
  to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Molecular basis for sunitinib efficacy and future clinical development
  S. Faivre and G. Demetri and W. Sargent and E. Raymond Nat.Rev.Drug Discov.6(9):734-745(2007)
  to & A Angiogenesis Animals Carcinoma Clinical Design Drug Endothelial Factor France Growth Humans Indoles Inhibitors Kinase Kinases Neoplasm Neoplasms Protein-Tyrosine Pyrroles Receptors Resistance Topic Trials Tyrosine Vascular adverse antagonists as biosynthesis blood drug effects enzymology inhibitors metabolism pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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• Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications
  J. Harper and M. A. Moses EXS(2006)
  to & Angiogenesis Capillaries Human Humans Inhibitors Neoplasms Neovascularization Pathologic Research blood control drug metabolism pathology pharmacology prevention supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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• The clinical toxicity profile of vascular endothelial growth factor VEGF and vascular endothelial growth factor receptor VEGFR targeting angiogenesis inhibitors; a review
  F. A. Eskens and J. Verweij Eur.J.Cancer42(18):3127-3139(2006)
  to & A Angiogenesis Antibodies Endothelial Factor Growth Humans Inhibitors Kinase Kinases Medical Monoclonal Neoplasms Neovascularization Oncology Pathologic Protein Protein-Tyrosine Receptors Tyrosine Vascular adverse antagonists blood control drug effects inhibitors prevention protein supply therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
  A. Morabito and Maio E. De and Maio M. Di and N. Normanno and F. Perrone Oncologist.11(7):753-764(2006)
  to & A Angiogenesis Clinical Endothelial Factor Growth Human Humans Inhibitors Kinase Kinases Lung Neoplasms Piperidines Protein Protein-Tyrosine Proteins Quinazolines Receptors Research Safety Topic Trials Tyrosine Vascular antagonists as drug inhibitors metabolism protein therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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• Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
  I. Shiojima and K. Walsh Genes Dev.20(24):3347-3365(2006)
  to & Adaptation Animals Cardiac Cardiomegaly Cell Contraction Differentiation Diseases Failure Growth Heart Humans Hypertension Myocardial Myocytes Neovascularization Physiologic Physiological Proteins Proto-Oncogene Signal Sports Transduction c-akt cytology development embryology genetics growth metabolism pathology physiology physiopathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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• Notch signaling in the regulation of tumor angiogenesis
  A. O. Rehman and C. Y. Wang Trends Cell Biol.16(6):293-300(2006)
  to & Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
  H. M. Verheul and H. M. Pinedo Nat.Rev.Cancer7(6):475-485(2007)
  to & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Circulating VEGF reduction, response and outcome in advanced colorectal cancer patients treated with cetuximab plus irinotecan
  B. Vincenzi and D. Santini and A. Russo and M. Gavasci and F. Battistoni and G. Dicuonzo and L. Rocci and V. M. Rosaria and N. Gebbia and G. Tonini Pharmacogenomics.8(4):319-327(2007)
  to & A Adult Aged Antibodies Antineoplastic Biological Camptothecin Chemotherapy Colorectal Combined Disease Endothelial Factor Female Growth Humans Male Markers Medical Middle Monoclonal Neoplasms Oncology Outcome Progression Prospective Protocols Rate Studies Survival Treatment Tumor Vascular administration analogs antagonists blood derivatives dosage drug inhibitors methods mortality response therapeutic therapy trends use by kanefendt on Feb 5, 2010, 11:28 AM
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