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Receptor tyrosine kinases: mechanisms of activation and signaling
S. R. Hubbard, and W. T. Miller Curr.Opin.Cell Biol. 19(2):117-123 (2007)
to Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology by kanefendt on Feb 5, 2010, 11:28 AM
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Key elements of bioanalytical method validation for macromolecules
M. Kelley, and B. DeSilva AAPS.J. 9(2):E156-E163 (2007)
to Antibodies Binding Chemistry Immunoassay Indicators Ligands Macromolecular Monoclonal Pharmaceutical Pharmacokinetics Preparations Reagents Reference Reproducibility Results Sensitivity Specificity Standards Substances analysis and metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Best practices during bioanalytical method validation for the characterization of assay reagents and the evaluation of analyte stability in assay standards, quality controls, and study samples
W. Nowatzke, and E. Woolf AAPS.J. 9(2):E117-E122 (2007)
to Animals Binding Biopharmaceutics Chemistry Control Drug Humans Pharmaceutical Pharmacokinetics Preparations Quality Reference Reproducibility Results Solutions Stability Standards analysis deficiency metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
P. Laakkonen, M. Waltari, T. Holopainen, T. Takahashi, B. Pytowski, P. Steiner, D. Hicklin, K. Persaud, J. R. Tonra, L. Witte, and K. Alitalo Cancer Res. 67(2):593-599 (2007)
to & Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Appropriate calibration curve fitting in ligand binding assays
J. W. Findlay, and R. F. Dillard AAPS.J. 9(2):E260-E267 (2007)
to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Notch signaling in the regulation of tumor angiogenesis
A. O. Rehman, and C. Y. Wang Trends Cell Biol. 16(6):293-300 (2006)
to & Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
C. T. Viswanathan, S. Bansal, B. Booth, A. J. DeStefano, M. J. Rose, J. Sailstad, V. P. Shah, J. P. Skelly, P. G. Swann, and R. Weiner Pharm.Res. 24(10):1962-1973 (2007)
to & Administration Animals Artifacts Assay Binding Biological Body Calibration Chemistry Chromatography Control Documentation Drug Fluids Food Government Guidelines Humans Macromolecular Pharmaceutical Quality Radioligand Reference Regulation Reproducibility Research Results Species Specificity Stability Standards States Substances Technology Topic United and as jurisprudence legislation methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Critical ligand binding reagent preparation/selection: when specificity depends on reagents
B. Rup, and D. O'Hara AAPS.J. 9(2):E148-E155 (2007)
to Antibodies Binding Chemistry Immunoassay Indicators Ligands Monoclonal Pharmaceutical Pharmacokinetics Preparations Reagents Reproducibility Research Results Safety Sensitivity Specificity and metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Workshop/Conference Report - Quantitative Bioanalytical Methods Validation and Implementation: Best Practices for Chromatographic and Ligand binding Assays
Bansal SBooth BDeStefano AJRose MJSailstad JShah VPSkelly JPSwann PGWeiner R. Viswanathan CT The AAPS Journal 9(1):E30-E42 (2007)
to Binding Ligand assays binding methods by kanefendt on Feb 5, 2010, 11:28 AM
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A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
F. T. Wu, M. O. Stefanini, Gabhann F. Mac, and A. S. Popel PLoS.One. 4(4):e5108 (2009)
to A Binding Biological Biology Capillaries Dimerization Endothelial Factor Growth Human Humans Ligands Lymphatic Models Muscle Plasma Receptor-1 Research Skeletal States Systems Tyrosine United Vascular Vessels metabolism physiology protein therapy ultrastructure by kanefendt on Feb 5, 2010, 11:28 AM
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Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis
J. W. Lee, and M. Hall J.Chromatogr.B Analyt.Technol.Biomed.Life Sci. (2008)
to Binding Population Prognosis RANGE States United diagnosis methods protein by kanefendt on Feb 5, 2010, 11:28 AM
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Evidence for the existence of a novel pregnancy-associated soluble variant of the vascular endothelial growth factor receptor, Flt-1
R. E. Banks, M. A. Forbes, J. Searles, D. Pappin, B. Canas, D. Rahman, S. Kaufmann, C. E. Walters, A. Jackson, P. Eves, G. Linton, J. Keen, J. J. Walker, and P. J. Selby Mol Hum.Reprod. 4(4):377-386 (1998)
to & A Acid Amino Binding Blood Cells Chain Chemistry Data Endothelial Factor Factors Female Fetal Growth Human Humans Kinase Kinases Lymphokines Male Molecular Placenta Polymerase Pregnancy Protein Protein-Tyrosine Proteins Proto-Oncogene Reaction Receptor Receptor-1 Research Reverse Sequence Solubility Transcriptase Umbilical Vascular Veins Weight blood cells cytology identify isolation metabolism protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, and H. A. Weich Exp.Cell Res. 241(1):161-170 (1998)
to & A Agents Animals BALB Binding C Cell Cells Cloning Competitive Cross-Linking Dimerization Endothelial Expression Factor Factors Fibrinolytic Gene Growth Heparin Human Humans Inbred Kinase Kinases Ligands Lymphokines Mice Mitogens Molecular Plastics Proliferation Protein Protein-Tyrosine Proteins Proto-Oncogene Reagents Receptor Receptor-1 Receptors Research Solubility Tyrosine Vascular antagonists cells drug effects genetics inhibitors isolation metabolism pharmacology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble VEGF receptors
C. Hornig, and H. A. Weich Angiogenesis. 3(1):33-39 (1999)
to Binding Cells Endothelial Human Research Signal Transduction blood cells by kanefendt on Feb 5, 2010, 11:28 AM
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Method dependence of interpretation of immunoassay results
U. H. Stenman, H. Alfthan, and U. Turpeinen Scand.J.Clin.Lab Invest Suppl (1991)
to & Animals Antibodies Antigens Binding Hormones Humans Immunoassay Neoplasm Peptides Protein Sensitivity Specificity analysis and data methods numerical standards statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza Mol.Cell Biol. 16(9):4604-4613 (1996)
to (Genetics) 1 40 A Acid Alignment Animals Base Binding Carcinoma Cell Cells Chemistry Cultured DNA-Binding Data Endothelial Expression Factor Factors Fusion Gene Genes Genetic Growth Hepatocellular Homology Human Humans Hypoxia Hypoxia-Inducible Liver Lymphokines Mice Molecular Neoplasms Nuclear Nucleic Promoter Proteins Rats Recombinant Regions Regulation Reporter Research Sequence Simian Subunit Transcription Transfection Tumor Vascular alpha biosynthesis cells genetics metabolism pathology physiology protein response virus by kanefendt on Feb 5, 2010, 11:28 AM
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Bioanalytical method validation for macromolecules in support of pharmacokinetic studies
J. Smolec, B. DeSilva, W. Smith, R. Weiner, M. Kelly, B. Lee, M. Khan, R. Tacey, H. Hill, A. Celniker, V. Shah, R. Bowsher, A. Mire-Sluis, J. W. Findlay, M. Saltarelli, V. Quarmby, D. Lansky, R. Dillard, M. Ullmann, S. Keller, and H. T. Karnes Pharm.Res. 22(9):1425-1431 (2005)
to Analytical Binding Calibration Chemistry Laboratories Pharmacokinetics Reference Reproducibility Results Sensitivity Specificity Standards and methods of by kanefendt on Feb 5, 2010, 11:28 AM
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Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer
L. C. Snyder, I. Astsaturov, and L. M. Weiner Clin.Colorectal Cancer (2005)
to & Administration Amplification Antibodies Approval Binding Colorectal Drug Epidermal Exanthema Factor Food Gene Growth Humans IgG Ligands Medical Molecular Monoclonal Neoplasms Oncology Phosphorylation Prognosis Receptor Receptors Signal Sites States Transduction Tyrosine United Weight and antagonists biosynthesis cells chemically drug induced inhibitors pharmacology physiology physiopathology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Comparison of Curve fitting Models for Ligand Binding Assays
Little JA (2004)
to Binding Comparison Ligand assays binding curve fitting of by kanefendt on Feb 5, 2010, 11:28 AM
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