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Receptor tyrosine kinases: mechanisms of activation and signaling
S. R. Hubbard, and W. T. Miller Curr.Opin.Cell Biol. 19(2):117-123 (2007)
to Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of lymphatic vascular development
T. Makinen, C. Norrmen, and T. V. Petrova Cell Mol.Life Sci. 64(15):1915-1929 (2007)
to A Angiopoietins Animals Biological Cells Cultured Endothelial Factor Growth Human Humans Inflammation Lymphangiogenesis Lymphatic Lymphedema Models Proteins Receptors Research Substances TIE Transport Vascular Vesicular Vessels analysis cells cytology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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The biology of epidermal growth factor receptor and its value as a prognostic/predictive factor
A. P. Dei Tos Int.J.Biol.Markers 22(1 Suppl 4):S3-S9 (2007)
to Antibodies Biological Epidermal Expression Factor Gene Growth Human Humans Immunohistochemistry Markers Monoclonal Neoplasms Neoplastic Prognosis Receptor Regulation Tyrosine analysis drug effects etiology identify pathology physiology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. E. Deprimo, and C. Bello Ann.Oncol (2007)
to Angiogenesis Biological Cells Endothelial Growth Humans Indoles Inhibitors Laboratories Markers Neoplasms Neovascularization Pathologic Proteins Pyrroles Research Tumor blood cells diagnosis drug effects metabolism methods pathology pharmacology protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular and cellular biomarkers for angiogenesis in clinical oncology
F. Bertolini, P. Mancuso, Y. Shaked, and R. S. Kerbel Drug Discov.Today 12(19-20):806-812 (2007)
to Angiogenesis Antigens Biological Cells Endothelial Humans Inhibitors Markers Microcirculation Neoplasms Neovascularization Pathologic Research Tumor blood cells diagnosis drug metabolism pathology pharmacology supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
T. Force, D. S. Krause, and R. A. van Etten Nat.Rev.Cancer 7(5):332-344 (2007)
to & Adaptor Antibodies Benzenesulfonates Biological Delivery Diseases Drug Enzyme Heart Human Humans Indoles Inhibitors Kinase Kinases Models Monoclonal Mutation Neoplasms Protein Protein-Tyrosine Proteins Proto-Oncogene Pyridines Pyrroles Quinazolines Research Signal Systems Transducing Tyrosine adverse antagonists c-abl cells chemically development drug effects growth induced inhibitors physiology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Fit-for-purpose method development and validation for successful biomarker measurement
J. W. Lee, V. Devanarayan, Y. C. Barrett, R. Weiner, J. Allinson, S. Fountain, S. Keller, I. Weinryb, M. Green, L. Duan, J. A. Rogers, R. Millham, P. J. O'Brien, J. Sailstad, M. Khan, C. Ray, and J. A. Wagner Pharm.Res. 23(2):312-328 (2006)
to Approval Biological Calibration Chemistry Control Data Design Drug Interpretation Markers Models Quality Reproducibility Research Results Statistical Terminology Topic analysis as of by kanefendt on Feb 5, 2010, 11:28 AM
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Measurement of plasma levels of vascular endothelial growth factor in prostate cancer patients: relationship with clinical stage, Gleason score, prostate volume, and serum prostate-specific antigen
J. L. Duque, K. R. Loughlin, R. M. Adam, P. Kantoff, E. Mazzucchi, and M. R. Freeman Clinics. 61(5):401-408 (2006)
to 80 A Adult Age Aged Antigen Biological Case-Control Distribution Endothelial Factor Growth Humans Immunoassay Male Markers Middle Neoplasm Neoplasms Nonparametric Organ Population Prognosis Prostate Prostate-Specific Prostatic Retrospective Size Staging Statistics Studies Tumor Vascular and blood methods over pathology physiology by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
A. Gampel, L. Moss, M. C. Jones, V. Brunton, J. C. Norman, and H. Mellor Blood 108(8):2624-2631 (2006)
to A Active Adult Biological Blood Cell Cells Compartmentation Cultured Endosomes Endothelial Factor GTP-Binding Growth Humans Kinases Laboratories Lysosomes Membrane Plasma Proteins Receptor-2 Recombinant Research Transport Tyrosine Vascular Vessels blood cells cytology drug effects metabolism pharmacology protein rab4 response src-Family by kanefendt on Feb 5, 2010, 11:28 AM
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Effects of aspirin on intra-platelet vascular endothelial growth factor, angiopoietin-1, and p-selectin levels in hypertensive patients
S. Nadar, A. D. Blann, and G. Y. Lip Am.J.Hypertens. 19(9):970-977 (2006)
to A Activation Aged Aggregation Angiopoietin-1 Aspirin Biological Blood Case-Control Count Cyclooxygenase Endothelial England Factor Female Follow-Up Growth Humans Hypertension Immunoassay Inhibitors Longitudinal Male Markers Middle Outcome P-Selectin Platelet Platelets Pressure Research Studies Thrombosis Treatment Vascular blood drug effects metabolism methods pharmacology physiopathology therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Notch signaling in the regulation of tumor angiogenesis
A. O. Rehman, and C. Y. Wang Trends Cell Biol. 16(6):293-300 (2006)
to & Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
H. M. Verheul, and H. M. Pinedo Nat.Rev.Cancer 7(6):475-485 (2007)
to & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating VEGF reduction, response and outcome in advanced colorectal cancer patients treated with cetuximab plus irinotecan
B. Vincenzi, D. Santini, A. Russo, M. Gavasci, F. Battistoni, G. Dicuonzo, L. Rocci, V. M. Rosaria, N. Gebbia, and G. Tonini Pharmacogenomics. 8(4):319-327 (2007)
to & A Adult Aged Antibodies Antineoplastic Biological Camptothecin Chemotherapy Colorectal Combined Disease Endothelial Factor Female Growth Humans Male Markers Medical Middle Monoclonal Neoplasms Oncology Outcome Progression Prospective Protocols Rate Studies Survival Treatment Tumor Vascular administration analogs antagonists blood derivatives dosage drug inhibitors methods mortality response therapeutic therapy trends use by kanefendt on Feb 5, 2010, 11:28 AM
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
C. T. Viswanathan, S. Bansal, B. Booth, A. J. DeStefano, M. J. Rose, J. Sailstad, V. P. Shah, J. P. Skelly, P. G. Swann, and R. Weiner Pharm.Res. 24(10):1962-1973 (2007)
to & Administration Animals Artifacts Assay Binding Biological Body Calibration Chemistry Chromatography Control Documentation Drug Fluids Food Government Guidelines Humans Macromolecular Pharmaceutical Quality Radioligand Reference Regulation Reproducibility Research Results Species Specificity Stability Standards States Substances Technology Topic United and as jurisprudence legislation methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
F. T. Wu, M. O. Stefanini, Gabhann F. Mac, and A. S. Popel PLoS.One. 4(4):e5108 (2009)
to A Binding Biological Biology Capillaries Dimerization Endothelial Factor Growth Human Humans Ligands Lymphatic Models Muscle Plasma Receptor-1 Research Skeletal States Systems Tyrosine United Vascular Vessels metabolism physiology protein therapy ultrastructure by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble angiogenesis markers in gastric tumor patients
P. Mysliwiec, K. Pawlak, R. Bandurski, and B. Kedra Folia Histochem.Cytobiol. 47(1):81-86 (2009)
to A Adult Aged Antigens Biological CD Care Case-Control Cell Endothelial Factor Female Growth Human Humans Male Markers Middle Neoplasms Neovascularization Pathologic Plasma Preoperative Receptor-2 Receptors Solubility Stomach Studies Surface Tumor Vascular blood metabolism protein supply surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of analytic methods for biomarkers used in drug development
C. H. Chau, O. Rixe, H. McLeod, and W. D. Figg Clin.Cancer Res. 14(19):5967-5976 (2008)
to Agents Animals Antineoplastic Biological Biomarkers Chemistry Design Drug Evaluation Genome Genomics Human Humans Markers Medical Mice Neoplasms Oncology Outcome Pharmaceutical Pharmacological Preclinical Research Treatment Tumor analysis drug metabolism methods pharmacology therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
H. J. Burstein, A. D. Elias, H. S. Rugo, M. A. Cobleigh, A. C. Wolff, P. D. Eisenberg, M. Lehman, B. J. Adams, C. L. Bello, S. E. Deprimo, C. M. Baum, and K. D. Miller J Clin Oncol 26(11):1810-1816 (2008)
to & Administration Adult Aged Agents Anthracyclines Antineoplastic Biological Breast Bridged Carcinoma Chemotherapy Combined Compounds Diseases Drug Fatigue Female Gastrointestinal Growth Hematologic Humans Indoles Inflammation Kinase Kinases Markers Middle Neoplasms Oral Plasma Protein-Tyrosine Protocols Pyrroles Rate Schedule Survival Taxoids Tumor Tyrosine administration adverse analysis antagonists blood chemically classification dosage drug effects induced inhibitors methods mortality response secondary therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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How well do angiogenesis inhibitors work? Biomarkers of response prove elusive
V. Brower J.Natl.Cancer Inst. 101(12):846-847 (2009)
to A Analysis Angiogenesis Animals Antibodies Benzenesulfonates Biological Cells Cytokines Disease-Free Endothelial Factor Growth Humans Indoles Inhibitors Markers Monoclonal Neoplasms Pyridines Pyrroles Survival Tumor Vascular blood drug effects metabolism mortality pathology pharmacology response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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