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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Best practices during bioanalytical method validation for the characterization of assay reagents and the evaluation of analyte stability in assay standards, quality controls, and study samples
W. Nowatzke, and E. Woolf AAPS.J. 9(2):E117-E122 (2007)
to Animals Binding Biopharmaceutics Chemistry Control Drug Humans Pharmaceutical Pharmacokinetics Preparations Quality Reference Reproducibility Results Solutions Stability Standards analysis deficiency metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular regulation of tumor angiogenesis: mechanisms and therapeutic implications
J. Harper, and M. A. Moses EXS (2006)
to & Angiogenesis Capillaries Human Humans Inhibitors Neoplasms Neovascularization Pathologic Research blood control drug metabolism pathology pharmacology prevention supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Fit-for-purpose method development and validation for successful biomarker measurement
J. W. Lee, V. Devanarayan, Y. C. Barrett, R. Weiner, J. Allinson, S. Fountain, S. Keller, I. Weinryb, M. Green, L. Duan, J. A. Rogers, R. Millham, P. J. O'Brien, J. Sailstad, M. Khan, C. Ray, and J. A. Wagner Pharm.Res. 23(2):312-328 (2006)
to Approval Biological Calibration Chemistry Control Data Design Drug Interpretation Markers Models Quality Reproducibility Research Results Statistical Terminology Topic analysis as of by kanefendt on Feb 5, 2010, 11:28 AM
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The clinical toxicity profile of vascular endothelial growth factor VEGF and vascular endothelial growth factor receptor VEGFR targeting angiogenesis inhibitors; a review
F. A. Eskens, and J. Verweij Eur.J.Cancer 42(18):3127-3139 (2006)
to & A Angiogenesis Antibodies Endothelial Factor Growth Humans Inhibitors Kinase Kinases Medical Monoclonal Neoplasms Neovascularization Oncology Pathologic Protein Protein-Tyrosine Receptors Tyrosine Vascular adverse antagonists blood control drug effects inhibitors prevention protein supply therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
C. T. Viswanathan, S. Bansal, B. Booth, A. J. DeStefano, M. J. Rose, J. Sailstad, V. P. Shah, J. P. Skelly, P. G. Swann, and R. Weiner Pharm.Res. 24(10):1962-1973 (2007)
to & Administration Animals Artifacts Assay Binding Biological Body Calibration Chemistry Chromatography Control Documentation Drug Fluids Food Government Guidelines Humans Macromolecular Pharmaceutical Quality Radioligand Reference Regulation Reproducibility Research Results Species Specificity Stability Standards States Substances Technology Topic United and as jurisprudence legislation methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarker method validation in anticancer drug development
J. Cummings, T. H. Ward, A. Greystoke, M. Ranson, and C. Dive Br.J.Pharmacol. 153(4):646-656 (2008)
to & Adherence Agents Animals Antineoplastic Assay Biomarkers Cell Clinical Control Death Drug Enzyme-Linked Europe Evaluation Guideline Guidelines Humans Immunosorbent Keratin-18 Laboratories Mass Pharmacological Preclinical Proteins Quality Reproducibility Research Results Spectrometry Terminology Topic Trials analysis as drug effects jurisprudence legislation methods of pharmacology protein standards therapeutic use by kanefendt on Feb 5, 2010, 11:28 AM
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Biomarkers of response and resistance to antiangiogenic therapy
R. K. Jain, D. G. Duda, C. G. Willett, D. V. Sahani, A. X. Zhu, J. S. Loeffler, T. T. Batchelor, and A. G. Sorensen Nat.Rev.Clin.Oncol. 6(6):327-338 (2009)
to & A Angiogenesis Biological Drug Endothelial Factor Growth Humans Hypertension Inhibitors Markers Neoplasm Neoplasms Neovascularization Pathologic Research Resistance Tumor Vascular antagonists blood control inhibitors metabolism prevention response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Harmonization of strategies for the validation of quantitative analytical procedures: A SFSTP proposal Part IV. Examples of application
P. Hubert, J. J. Nguyen-Huu, B. Boulanger, E. Chapuzet, N. Cohen, P. A. Compagnon, W. Dewe, M. Feinberg, M. Laurentie, N. Mercier, G. Muzard, L. Valat, and E. Rozet J.Pharm.Biomed.Anal. 48(3):760-771 (2008)
to Chemistry Chromatography Control Laboratories Quality RANGE Research methods by kanefendt on Feb 5, 2010, 11:28 AM
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Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells
A. Yano, Y. Fujii, A. Iwai, S. Kawakami, Y. Kageyama, and K. Kihara Clin.Cancer Res. 12(20 Pt 1):6012-6017 (2006)
to & Animals C Cell Chain Dexamethasone Endothelial Expression Factor Gene Glucocorticoids Growth Heterologous Human Humans Japan Line Lymphangiogenesis Lymphatic Male Metastasis Mice Neoplasms Neoplastic Polymerase Prostate Prostatic Reaction Receptor-3 Regulation Reverse Transcriptase Transplantation Tumor Vascular cells control drug effects genetics pathology pharmacology prevention protein by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective
J. W. Findlay, W. C. Smith, J. W. Lee, G. D. Nordblom, I. Das, B. S. DeSilva, M. N. Khan, and R. R. Bowsher J.Pharm.Biomed.Anal. 21(6):1249-1273 (2000)
to Algorithms Antibodies Calibration Control Disease Immunoassay Molecular Progression Quality Reproducibility Results Safety Sensitivity Specificity Weight analysis and metabolism methods of protein response standards by kanefendt on Feb 5, 2010, 11:28 AM
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"Matrix effects" in immunoassays
W. G. Wood Scand.J.Clin.Lab Invest Suppl (1991)
to & Antibodies Buffers Control Hormone Humans Immunoassay Parathyroid Quality Reference Standards Thyrotropin blood data methods numerical standards statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Guidelines for immunoassay data processing
R. A. Dudley, P. Edwards, R. P. Ekins, D. J. Finney, I. G. McKenzie, G. M. Raab, D. Rodbard, and R. P. Rodgers Clin.Chem. 31(8):1264-1271 (1985)
to Computers Control Humans Immunoassay Immunologic Laboratories Mathematics Quality Reference Software Techniques Values by kanefendt on Feb 5, 2010, 11:28 AM
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An assessment of the 4-6-20 rule for acceptance of analytical runs in bioavailability, bioequivalence, and pharmacokinetic studies
R. O. Kringle Pharm.Res. 11(4):556-560 (1994)
to Analysis Availability Biological Control Design Equivalency Models Multivariate Pharmacokinetics Quality Research Statistical Therapeutic methods by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
Y. He, I. Rajantie, K. Pajusola, M. Jeltsch, T. Holopainen, S. Yla-Herttuala, T. Harding, K. Jooss, T. Takahashi, and K. Alitalo Cancer Res. 65(11):4739-4746 (2005)
to & Adenoviridae Animals Antitumor Assays Cell Cells Endothelial Endothelium Factor Fusion Genetic Growth Humans Immunoglobulins Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Model Neoplasm Neoplasms Neovascularization Nodes Pathologic Proteins Receptor-3 Recombinant Research Scid Signal Staging Transduction Tumor Vascular Vectors Vessels Xenograft administration antagonists cells control dosage genetics inhibitors pathology physiology prevention protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Workshop on bioanalytical methods validation for macromolecules: summary report
K. J. Miller, R. R. Bowsher, A. Celniker, J. Gibbons, S. Gupta, J. W. Lee, S. J. Swanson, W. C. Smith, and R. S. Weiner Pharm.Res. 18(9):1373-1383 (2001)
to Assay Biological Chemistry Control Drug Immunoassay Industry Ligands Macromolecular Pharmacokinetics Proteins Quality Recombinant Reproducibility Results Substances metabolism methods of pharmacology protein standards by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble Tie2 and Flt1 extracellular domains in serum of patients with renal cancer and response to antiangiogenic therapy
A. L. Harris, P. Reusch, B. Barleon, C. Hang, N. Dobbs, and D. Marme Clin.Cancer Res. 7(7):1992-1997 (2001)
to & Aged Agents Analysis Antineoplastic Assay Binding Endothelial Enzyme-Linked Factor Female Growth Humans Immunosorbent Kidney Kinase Kinases Laboratories Male Middle Multivariate Neoplasms Neovascularization Outcome Pathologic Prognosis Protein-Tyrosine Proteins Proto-Oncogene Razoxane Receptor Receptor-1 Research Sites Solubility Survival TIE-2 Treatment Tyrosine Vascular blood control drug effects pathology prevention protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
Y. He, K. Kozaki, T. Karpanen, K. Koshikawa, S. Yla-Herttuala, T. Takahashi, and K. Alitalo J.Natl.Cancer Inst. 94(11):819-825 (2002)
to & Animals Antibodies Blotting C Cell Cells Cultured D Division Endothelial Expression Factor Factors Female Gene Growth Human Humans Kinase Kinases Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Neoplasm Neoplasms Neoplastic Nodes Protein-Tyrosine RNA Receptor Receptor-3 Receptors Regulation Research Scid Signal Time Transduction Transfection Transplantation Tumor Vascular Vessels Western antagonists blood cells control genetics immunology inhibitors metabolism methods pathology prevention protein secondary supply by kanefendt on Feb 5, 2010, 11:28 AM
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