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• Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
  J. M. Ebos and C. R. Lee and J. G. Christensen and A. J. Mutsaers and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A104(43):17069-17074(2007)
  to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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• Vascular endothelial growth factor-D and its receptor VEGFR-3: two novel independent prognostic markers in gastric adenocarcinoma
  S. Juttner and C. Wissmann and T. Jons and M. Vieth and J. Hertel and S. Gretschel and P. M. Schlag and W. Kemmner and M. Hocker J.Clin.Oncol.24(2):228-240(2006)
  to 80 Adenocarcinoma Adult Aged Antibodies C Cell Chemistry D Disease-Free Endothelial Factor Growth Humans Immunohistochemistry Laboratories Line Lymphatic Messenger Metastasis Middle Neoplasms Prognosis RNA Receptor-3 Research Stomach Survival Tumor Vascular analysis and blood genetics identify methods mortality over supply by kanefendt on Feb 5, 2010, 11:28 AM
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• Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
  R. Kumar and M. C. Crouthamel and D. H. Rominger and R. R. Gontarek and P. J. Tummino and R. A. Levin and A. G. King Br.J.Cancer101(10):1717-1723(2009)
  to & 3 50 Angiogenesis Benzenesulfonates Bone Cell Cells Concentration Diseases Endothelial Factor Growth Hematologic Hematopoietic Human Humans Indoles Inhibitors Inhibitory Kinase Line Marrow Myelopoiesis Phosphorylation Platelet-Derived Protein Proteins Proto-Oncogene Pyridines Pyrimidines Pyrroles Receptors Research Specificity Stem Substrate Sulfonamides Tumor Tyrosine Vascular antagonists c-kit chemically drug effects enzymology fms-Like induced inhibitors methods pharmacology protein by kanefendt on Feb 5, 2010, 11:28 AM
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• Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
  T. Tammela and G. Zarkada and E. Wallgard and A. Murtomaki and S. Suchting and M. Wirzenius and M. Waltari and M. Hellstrom and T. Schomber and R. Peltonen and C. Freitas and A. Duarte and H. Isoniemi and P. Laakkonen and G. Christofori and S. Yla-Herttuala and M. Shibuya and B. Pytowski and A. Eichmann and C. Betsholtz and K. Alitalo Nature454(7204):656-660(2008)
  to & Adult Angiogenesis Animals Antibodies BALB Blood C Cell Cells Dipeptides Down-Regulation Endothelial Endothelium Expression Factor Factors Female Gene Growth Humans Inbred Inhibitors Laboratories Ligands Line Lymphangiogenesis Mice Monoclonal Neoplasms Neoplastic Neovascularization Notch Pathologic Proliferation Receptor-3 Receptors Regulation Research Signal Transduction Transgenic Tumor Tyrosine Vascular Vessels antagonists blood cells drug effects genetics inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines
  N. Simiantonaki and C. Jayasinghe and R. Michel-Schmidt and K. Peters and M. I. Hermanns and C. J. Kirkpatrick Int.J.Oncol.32(3):585-592(2008)
  to 1 Adenocarcinoma Autocrine Breast C Carcinoma Cell Colorectal Communication Endothelial Expression Factor Gene Growth Human Humans Hypoxia Hypoxia-Inducible Line Lung Neoplasms Neoplastic Oxygen Receptor-1 Receptor-2 Receptor-3 Regulation Subunit Survival Tumor Up-Regulation Vascular alpha cells genetics metabolism pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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• Expression of vascular endothelial growth factor-C and its receptor in osteosarcomas
  H. R. Park and K. Min and H. S. Kim and W. W. Jung and Y. K. Park Pathol.Res.Pract.204(8):575-582(2008)
  to Adolescent Adult Aged Bone C Cell Chain Child Cytoplasm D Endothelial Expression Factor Female Gene Growth Human Humans Immunohistochemistry Line Lymphatic Male Messenger Metastasis Middle Neoplasm Neoplasms Neoplastic Osteosarcoma Polymerase RNA Reaction Receptor-3 Regulation Research Up-Regulation Vascular Vessels cells genetics metabolism pathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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• VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
  T. V. Petrova and P. Bono and W. Holnthoner and J. Chesnes and B. Pytowski and H. Sihto and P. Laakkonen and P. Heikkila and H. Joensuu and K. Alitalo Cancer Cell13(6):554-556(2008)
  to Antibodies Antibody Blood Blotting Cell Cells Chain Chemistry Cytometry Endothelial Factor Flow Growth Humans Immunohistochemistry Line Lymphatic Messenger Neoplasms Northern Polymerase RNA Reaction Receptor-3 Reproducibility Results Reverse Separation Specificity Transcriptase Tumor Vascular Vessels Western analysis blood genetics immunology methods of pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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• Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells
  A. Yano and Y. Fujii and A. Iwai and S. Kawakami and Y. Kageyama and K. Kihara Clin.Cancer Res.12(20 Pt 1):6012-6017(2006)
  to & Animals C Cell Chain Dexamethasone Endothelial Expression Factor Gene Glucocorticoids Growth Heterologous Human Humans Japan Line Lymphangiogenesis Lymphatic Male Metastasis Mice Neoplasms Neoplastic Polymerase Prostate Prostatic Reaction Receptor-3 Regulation Reverse Transcriptase Transplantation Tumor Vascular cells control drug effects genetics pathology pharmacology prevention protein by kanefendt on Feb 5, 2010, 11:28 AM
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• Vascular endothelial growth factor governs endothelial nitric-oxide synthase expression via a KDR/Flk-1 receptor and a protein kinase C signaling pathway
  B. Q. Shen and D. Y. Lee and T. F. Zioncheck J.Biol.Chem.274(46):33057-33063(1999)
  to & A Adrenal Animals Aorta C Cattle Cell Cells Cortex Cultured Endothelial Endothelium Enzyme Enzymologic Ester Expression Factor Factors Gene Growth II Inhibitors Kinase Kinases Line Lymphokines Methyl NG-Nitroarginine Nitric Oxide Penicillamine Pharmacokinetics Protein Protein-Tyrosine Proteins Receptor Receptors Recombinant Regulation Signal Substances Synthase Transduction Type Tyrosine Up-Regulation Vascular analogs cells derivatives drug effects metabolism pharmacology protein by kanefendt on Feb 5, 2010, 11:28 AM
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• Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
  R. Mohle and D. Green and M. A. Moore and R. L. Nachman and S. Rafii Proc.Natl.Acad.Sci.U.S.A94(2):663-668(1997)
  to A Alternative Blood Cell Cells Complex Cultured Cytokines Endothelial Endothelium Expression Factor Factors GPIIb-IIIa Gene Glycoprotein Growth Hematopoiesis Human Humans Immunohistochemistry Kinase Kinases Laboratories Line Lymphokines Megakaryocytes Neovascularization Physiologic Platelet Platelets Protein-Tyrosine Receptor Receptors Research Splicing Thrombin Vascular analysis cells cytology genetics metabolism pharmacology protein secretion by kanefendt on Feb 5, 2010, 11:28 AM
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• Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
  M. J. Karkkainen and R. E. Ferrell and E. C. Lawrence and M. A. Kimak and K. L. Levinson and M. A. McTigue and K. Alitalo and D. N. Finegold Nat.Genet.25(2):153-159(2000)
  to 5 Activation Alleles Animals C Cell Chemistry Chromosomes Data Dominant Endothelial Enzyme Factor Factors Female Fusion Genes Growth Half-Life Human Humans Infant Kinase Kinases Laboratories Line Lymphedema Male Mice Missense Models Molecular Mutation Newborn Pair Pedigree Phosphorylation Protein Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Sequence Signal Stability Structure Surface Transcriptional Transduction Tyrosine Vascular congenital drug effects genetics metabolism pharmacology protein secondary by kanefendt on Feb 5, 2010, 11:28 AM
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• Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
  P. Chomczynski and N. Sacchi Anal.Biochem.162(1):156-159(1987)
  to & Animal Animals Cell Chloroform Concentration Glands Guanidine Guanidines Humans Hydrogen-Ion Line Mammary Phenol Phenols RNA Rats Solutions analysis cells isolation purification by kanefendt on Feb 5, 2010, 11:28 AM
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• FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
  K. Pajusola and O. Aprelikova and J. Korhonen and A. Kaipainen and L. Pertovaara and R. Alitalo and K. Alitalo Cancer Res.52(20):5738-5743(1992)
  to & Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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• Expression of heregulin in human coronary atherosclerotic lesions
  D. Panutsopulos and D. L. Arvanitis and C. Tsatsanis and E. Papalambros and F. Sigala and D. A. Spandidos J.Vasc.Res.42(6):463-474(2005)
  to 80 A Adult Aged Arteries Artery Cell Cells Coronary Disease Endothelial Epithelial Factor Female Growth Human Humans Immediate-Early Intercellular Laboratories Line Macrophages Male Messenger Middle Monocytes Neuregulin-1 Peptides Proteins RNA Signaling Vascular and blood cells genetics metabolism methods over pathology physiopathology protein response secretion by kanefendt on Feb 5, 2010, 11:28 AM
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• Increased plasma vascular endothelial growth factor VEGF as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies
  G. Bocci and S. Man and S. K. Green and G. Francia and J. M. Ebos and J. M. Du Manoir and A. Weinerman and U. Emmenegger and L. Ma and P. Thorpe and A. Davidoff and J. Huber and D. J. Hicklin and R. S. Kerbel Cancer Res.64(18):6616-6625(2004)
  to & A Adenocarcinoma Administration Angiogenesis Animals Antibodies Antineoplastic Biological Blood Cell Chemotherapy Colorectal Combined Drug Endothelial Factor Growth Human Humans Inhibitors Line Male Markers Messenger Mice Modality Monoclonal Neoplasms Neovascularization Nude Pathologic Platelets Prostatic Protocols RNA Receptor-2 Research Schedule Scid Therapy Tumor Vascular administration biosynthesis blood dosage genetics immunology metabolism protein supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• A naturally occurring soluble form of vascular endothelial growth factor receptor 2 detected in mouse and human plasma
  J. M. Ebos and G. Bocci and S. Man and P. E. Thorpe and D. J. Hicklin and D. Zhou and X. Jia and R. S. Kerbel Mol.Cancer Res.2(6):315-326(2004)
  to Animals Antibodies Binding Cell Cells Chemistry Conditioned Culture Endothelial Factor Factors Glycosylation Growth Health Human Humans Immunoprecipitation Line Media Mice Molecular Plasma Protein Receptor-2 Research Solubility Tyrosine Vascular Weight blood cells immunology metabolism protein secretion by kanefendt and 1 other person on Feb 5, 2010, 11:28 AM
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• Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
  J. Lin and A. S. Lalani and T. C. Harding and M. Gonzalez and W. W. Wu and B. Luan and G. H. Tu and K. Koprivnikar and M. J. VanRoey and Y. He and K. Alitalo and K. Jooss Cancer Res.65(15):6901-6909(2005)
  to Adenoviridae Animals C Carcinoma Cell Endothelial Factor Female Gene Genetic Growth Human Humans Kidney Line Lung Lymph Lymphangiogenesis Lymphatic Male Melanoma Metastasis Mice Neoplasms Nodes Nude Prostate Prostatic Receptor-3 Renal Techniques Therapy Transfer Tumor Vascular Vectors biosynthesis blood cells genetics immunology methods pathology secondary therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model
  F. R. Luo and Z. Yang and H. Dong and A. Camuso and K. McGlinchey and K. Fager and C. Flefleh and D. Kan and I. Inigo and S. Castaneda and T. W. Wong and R. A. Kramer and R. Wild and F. Y. Lee Clin.Cancer Res.11(15):5558-5565(2005)
  to Agents Animals Antibodies Antigen Antineoplastic Antitumor Assay Assays Biological Carcinoma Cell Chemistry Colonic Enzyme-Linked Epidermal Factor Factors Female G Growth Human Humans Immunoglobulin Immunohistochemistry Immunosorbent Ki-67 Kinase Line MAP Markers Mice Model Monoclonal Neoplasm Neoplasms Nude Pharmacokinetics Phosphorylation Receptor Research Signaling System Time Transplantation Tumor Tyrosine Xenograft analysis biosynthesis drug metabolism methods pathology pharmacology protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
  Y. He and I. Rajantie and K. Pajusola and M. Jeltsch and T. Holopainen and S. Yla-Herttuala and T. Harding and K. Jooss and T. Takahashi and K. Alitalo Cancer Res.65(11):4739-4746(2005)
  to & Adenoviridae Animals Antitumor Assays Cell Cells Endothelial Endothelium Factor Fusion Genetic Growth Humans Immunoglobulins Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Model Neoplasm Neoplasms Neovascularization Nodes Pathologic Proteins Receptor-3 Recombinant Research Scid Signal Staging Transduction Tumor Vascular Vectors Vessels Xenograft administration antagonists cells control dosage genetics inhibitors pathology physiology prevention protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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• Lymphatic endothelium: a new frontier of metastasis research
  M. J. Karkkainen and T. Makinen and K. Alitalo Nat.Cell Biol.4(1):E2-E5(2002)
  to Biological C Cell Culture D Endothelial Endothelium Factor Factors Growth Humans Kinase Kinases Line Lymphatic Markers Metastasis Movement Neoplasm Neoplasms Neovascularization Pathologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Techniques Vascular Vessels blood pathology physiology physiopathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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