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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
A. Morabito, Maio E. De, Maio M. Di, N. Normanno, and F. Perrone Oncologist. 11(7):753-764 (2006)
to & A Angiogenesis Clinical Endothelial Factor Growth Human Humans Inhibitors Kinase Kinases Lung Neoplasms Piperidines Protein Protein-Tyrosine Proteins Quinazolines Receptors Research Safety Topic Trials Tyrosine Vascular antagonists as drug inhibitors metabolism protein therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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EGFR FISH versus mutation: different tests, different end-points
F. Cappuzzo Lung Cancer 60(2):160-165 (2008)
to & Analysis Carcinoma Clinical DNA Drug Epidermal Factor Fluorescence Growth Humans Hybridization In Inhibitors Kinase Lung Mutation Mutational Neoplasm Neoplasms Non-Small-Cell Patient Population Protein Receptor Resistance Selection Situ Topic Trials Tyrosine analysis antagonists as drug genetics identify inhibitors protein response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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High VEGFR-3-positive circulating lymphatic/vascular endothelial progenitor cell level is associated with poor prognosis in human small cell lung cancer
K. Bogos, F. Renyi-Vamos, J. Dobos, I. Kenessey, J. Tovari, J. Timar, J. Strausz, G. Ostoros, W. Klepetko, H. J. Ankersmit, G. Lang, M. A. Hoda, P. Nierlich, and B. Dome Clin.Cancer Res. 15(5):1741-1746 (2009)
to Adult Aged Antibodies Assay Bone C Capillaries Carcinoma Case-Control Cell Cells Cytometry Disease Endothelial Enzyme-Linked Factor Female Flow Follow-Up Growth Human Humans Immunosorbent Lung Lymphatic Male Marrow Metastasis Middle Neoplasms Population Prognosis Progression Rate Receptor-3 Research Small Stem Studies Survival Vascular Vessels blood cells metabolism pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Hypoxia-induced epithelial VEGF-C/VEGFR-3 upregulation in carcinoma cell lines
N. Simiantonaki, C. Jayasinghe, R. Michel-Schmidt, K. Peters, M. I. Hermanns, and C. J. Kirkpatrick Int.J.Oncol. 32(3):585-592 (2008)
to 1 Adenocarcinoma Autocrine Breast C Carcinoma Cell Colorectal Communication Endothelial Expression Factor Gene Growth Human Humans Hypoxia Hypoxia-Inducible Line Lung Neoplasms Neoplastic Oxygen Receptor-1 Receptor-2 Receptor-3 Regulation Subunit Survival Tumor Up-Regulation Vascular alpha cells genetics metabolism pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
O. Aprelikova, K. Pajusola, J. Partanen, E. Armstrong, R. Alitalo, S. K. Bailey, J. McMahon, J. Wasmuth, K. Huebner, and K. Alitalo Cancer Res. 52(3):746-748 (1992)
to 5 Acid Adult Amino Banding Blotting Cell Chain Chromosome Chromosomes Data Dna Homology Human Humans Kidney Kinase Kinases Leukemia Lung Messenger Molecular Northern Nucleic Organ Pair Placenta Polymerase Protein-Tyrosine RNA Reaction Receptors Research Sequence Specificity Surface Tyrosine analysis cells genetics by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
K. Pajusola, O. Aprelikova, J. Korhonen, A. Kaipainen, L. Pertovaara, R. Alitalo, and K. Alitalo Cancer Res. 52(20):5738-5743 (1992)
to & Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues
H. Bando, M. Brokelmann, M. Toi, K. Alitalo, J. P. Sleeman, B. Sipos, H. J. Grone, and H. A. Weich Int.J.Cancer 111(2):184-191 (2004)
to Animals Antibodies Assay Carcinoma Cells Chemistry Cultured Distribution Endothelial Enzyme-Linked Factor Goats Growth Human Humans Immunosorbent Kidney Ligands Lung Mice Monoclonal Neoplasms Neovascularization Pathologic RANGE Receptor-3 Research Sensitivity Specificity Tissue Tumor Vascular analysis and cells diagnostic immunology methods pathology protein use by kanefendt on Feb 5, 2010, 11:28 AM
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A phase 1 study of SU11248 in the treatment of patients with refractory or resistant acute myeloid leukemia AML or not amenable to conventional therapy for the disease
W. Fiedler, H. Serve, H. Dohner, M. Schwittay, O. G. Ottmann, A. M. O'Farrell, C. L. Bello, R. Allred, W. C. Manning, J. M. Cherrington, S. G. Louie, W. Hong, N. M. Brega, G. Massimini, P. Scigalla, W. E. Berdel, and D. K. Hossfeld Blood 105(3):986-993 (2005)
to & 3 Acute Aged Clearance Endothelial Factor Female Follow-Up Genotype Growth Human Humans Hypertension Indoles Kinase Kinases Leukemia Lung Male Metabolic Middle Mutation Myeloid Pharmacokinetics Platelet-Derived Protein-Tyrosine Proteins Proto-Oncogene Pyrroles Rate Receptor Receptors Research SU11248 Studies Tyrosine Vascular analysis antagonists cells drug fms-Like genetics inhibitors protein response therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Inhibition of lymphogenous metastasis using adeno-associated virus-mediated gene transfer of a soluble VEGFR-3 decoy receptor
J. Lin, A. S. Lalani, T. C. Harding, M. Gonzalez, W. W. Wu, B. Luan, G. H. Tu, K. Koprivnikar, M. J. VanRoey, Y. He, K. Alitalo, and K. Jooss Cancer Res. 65(15):6901-6909 (2005)
to Adenoviridae Animals C Carcinoma Cell Endothelial Factor Female Gene Genetic Growth Human Humans Kidney Line Lung Lymph Lymphangiogenesis Lymphatic Male Melanoma Metastasis Mice Neoplasms Nodes Nude Prostate Prostatic Receptor-3 Renal Techniques Therapy Transfer Tumor Vascular Vectors biosynthesis blood cells genetics immunology methods pathology secondary therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
Y. He, I. Rajantie, K. Pajusola, M. Jeltsch, T. Holopainen, S. Yla-Herttuala, T. Harding, K. Jooss, T. Takahashi, and K. Alitalo Cancer Res. 65(11):4739-4746 (2005)
to & Adenoviridae Animals Antitumor Assays Cell Cells Endothelial Endothelium Factor Fusion Genetic Growth Humans Immunoglobulins Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Model Neoplasm Neoplasms Neovascularization Nodes Pathologic Proteins Receptor-3 Recombinant Research Scid Signal Staging Transduction Tumor Vascular Vectors Vessels Xenograft administration antagonists cells control dosage genetics inhibitors pathology physiology prevention protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
Y. He, K. Kozaki, T. Karpanen, K. Koshikawa, S. Yla-Herttuala, T. Takahashi, and K. Alitalo J.Natl.Cancer Inst. 94(11):819-825 (2002)
to & Animals Antibodies Blotting C Cell Cells Cultured D Division Endothelial Expression Factor Factors Female Gene Growth Human Humans Kinase Kinases Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Neoplasm Neoplasms Neoplastic Nodes Protein-Tyrosine RNA Receptor Receptor-3 Receptors Regulation Research Scid Signal Time Transduction Transfection Transplantation Tumor Vascular Vessels Western antagonists blood cells control genetics immunology inhibitors metabolism methods pathology prevention protein secondary supply by kanefendt on Feb 5, 2010, 11:28 AM
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