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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
P. Laakkonen, M. Waltari, T. Holopainen, T. Takahashi, B. Pytowski, P. Steiner, D. Hicklin, K. Persaud, J. R. Tonra, L. Witte, and K. Alitalo Cancer Res. 67(2):593-599 (2007)
to & Animals Antibodies Antitumor Assays BALB Binding C Cell D Endothelial Factor Growth Human Humans Immunohistochemistry Inbred Ligands Mice Model Monoclonal Neoplasms Neovascularization Nude Pathologic Processes Receptor-3 Research Vascular Xenograft analysis antagonists blood immunology inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib
T. F. Chu, M. A. Rupnick, R. Kerkela, S. M. Dallabrida, D. Zurakowski, L. Nguyen, K. Woulfe, E. Pravda, F. Cassiola, J. Desai, S. George, J. A. Morgan, D. M. Harris, N. S. Ismail, J. H. Chen, F. J. Schoen, A. D. van den Abbeele, G. D. Demetri, T. Force, and M. H. Chen Lancet 370(9604):2011-2019 (2007)
to & Aged Agents Animals Antineoplastic Arteries Artery Blood Carcinoma Coronary Disease Failure Female Gastrointestinal Heart Humans Hypertension Indoles Kinase Kinases Male Mice Middle Multicenter Pressure Protein-Tyrosine Pyrroles Rats Research Retrospective Safety Stroke Stromal Studies Topic Tumors Tyrosine Volume adverse antagonists as blood chemically drug effects induced inhibitors methods therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. M. Ebos, C. R. Lee, J. G. Christensen, A. J. Mutsaers, and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A 104(43):17069-17074 (2007)
to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
M. Shibuya J Biochem.Mol.Biol. 39(5):469-478 (2006)
to A Animals Atherosclerosis Cells Chemistry Development Dna Embryonic Endothelial Factor Female Growth Human Humans Inflammation Japan Metastasis Mice Neoplasm Neoplasms Neovascularization Pathologic Physiologic Pre-Eclampsia Pregnancy Proteins Receptor-1 Receptor-2 Research Signal Transduction Tyrosine Vascular Viral blood cells genetics metabolism physiology physiopathology protein response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of analytic methods for biomarkers used in drug development
C. H. Chau, O. Rixe, H. McLeod, and W. D. Figg Clin.Cancer Res. 14(19):5967-5976 (2008)
to Agents Animals Antineoplastic Biological Biomarkers Chemistry Design Drug Evaluation Genome Genomics Human Humans Markers Medical Mice Neoplasms Oncology Outcome Pharmaceutical Pharmacological Preclinical Research Treatment Tumor analysis drug metabolism methods pharmacology therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor-mediated decrease in plasma soluble vascular endothelial growth factor receptor-2 levels as a surrogate biomarker for tumor growth
J. M. Ebos, C. R. Lee, E. Bogdanovic, J. Alami, Slyke P. Van, G. Francia, P. Xu, A. J. Mutsaers, D. J. Dumont, and R. S. Kerbel Cancer Res. 68(2):521-529 (2008)
to A Adenocarcinoma Adenoviridae Animals BALB Biological Burden C C57BL Cell Cells Cultured Disease Endothelial Experimental Factor Female Genetic Growth HT29 Heterologous Human Humans Inbred Male Mammary Markers Mice Neoplasm Neoplasms Progression Proliferation Prostatic Receptor-2 Research Solubility Transduction Transfection Transgenic Transplantation Tumor Tyrosine Vascular blood cells genetics metabolism methods pathology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF receptor protein-tyrosine kinases: structure and regulation
R. Jr Roskoski Biochem.Biophys.Res.Commun. 375(3):287-291 (2008)
to Animals Chemistry Conformation Endothelial Factor Growth Human Humans Kinase Kinases Mice Phosphorylation Protein Protein-Tyrosine Receptor Receptor-1 Receptors Research Tyrosine Vascular blood classification metabolism by kanefendt on Feb 5, 2010, 11:28 AM
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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
T. Tammela, G. Zarkada, E. Wallgard, A. Murtomaki, S. Suchting, M. Wirzenius, M. Waltari, M. Hellstrom, T. Schomber, R. Peltonen, C. Freitas, A. Duarte, H. Isoniemi, P. Laakkonen, G. Christofori, S. Yla-Herttuala, M. Shibuya, B. Pytowski, A. Eichmann, C. Betsholtz, and K. Alitalo Nature 454(7204):656-660 (2008)
to & Adult Angiogenesis Animals Antibodies BALB Blood C Cell Cells Dipeptides Down-Regulation Endothelial Endothelium Expression Factor Factors Female Gene Growth Humans Inbred Inhibitors Laboratories Ligands Line Lymphangiogenesis Mice Monoclonal Neoplasms Neoplastic Neovascularization Notch Pathologic Proliferation Receptor-3 Receptors Regulation Research Signal Transduction Transgenic Tumor Tyrosine Vascular Vessels antagonists blood cells drug effects genetics inhibitors metabolism pharmacology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
S. Swendeman, K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel Circ.Res. 103(9):916-918 (2008)
to A ADAM Amyloid Animals Cells Cercopithecus Cos Endothelial Extracellular Factor Factor-alpha Factors Fibroblasts Fusion Growth Human Humans Kinases Knockout MAP Membrane Mice Necrosis Neuropilin-1 Phosphorylation Precursor Protein Proteins Receptor-2 Recombinant Research Secretases Signal Signal-Regulated Swine Time Transduction Transfection Tumor Vascular aethiops cells deficiency enzymology genetics metabolism protein surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular biology and pathology of lymphangiogenesis
T. Karpanen, and K. Alitalo Annu.Rev.Pathol. (2008)
to Animal Animals Biological Biology Developmental Endothelial Endothelium Expression Factors Gene Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Markers Mice Models Molecular Regulation Research System Vascular Vessels cytology genetics metabolism methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Glucocorticoids suppress tumor lymphangiogenesis of prostate cancer cells
A. Yano, Y. Fujii, A. Iwai, S. Kawakami, Y. Kageyama, and K. Kihara Clin.Cancer Res. 12(20 Pt 1):6012-6017 (2006)
to & Animals C Cell Chain Dexamethasone Endothelial Expression Factor Gene Glucocorticoids Growth Heterologous Human Humans Japan Line Lymphangiogenesis Lymphatic Male Metastasis Mice Neoplasms Neoplastic Polymerase Prostate Prostatic Reaction Receptor-3 Regulation Reverse Transcriptase Transplantation Tumor Vascular cells control drug effects genetics pathology pharmacology prevention protein by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiovascular failure in mouse embryos deficient in VEGF receptor-3
D. J. Dumont, L. Jussila, J. Taipale, A. Lymboussaki, T. Mustonen, K. Pajusola, M. Breitman, and K. Alitalo Science 282(5390):946-949 (1998)
to Adult Animals Antigens Blood C CD31 Cardiovascular Cell Chemistry Development Embryo Embryonic Endothelial Endothelium Factor Factors Fetal Gene Growth Hematopoiesis Heterozygote Homozygote Hybridization Immunohistochemistry In Kinase Kinases Ligands Lymphatic Mammalian Mice Neovascularization Physiologic Protein-Tyrosine Receptor Receptor-3 Receptors Research Signal Situ Surface System Targeting Transduction Vascular Vessels analysis and blood embryology genetics physiology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia
I. Stein, A. Itin, P. Einat, R. Skaliter, Z. Grossman, and E. Keshet Mol.Cell Biol. 18(6):3112-3119 (1998)
to 3T3 A Animals Biosynthesis Cell Cells Cultured Endothelial Factor Factors Growth Humans Hypoxia Lymphokines Messenger Mice Neovascularization Oxygen Pathologic Protein RNA Rats Research Ribosomes Vascular biosynthesis cells genetics identify metabolism protein by kanefendt on Feb 5, 2010, 11:28 AM
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Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
W. Roeckl, D. Hecht, H. Sztajer, J. Waltenberger, A. Yayon, and H. A. Weich Exp.Cell Res. 241(1):161-170 (1998)
to & A Agents Animals BALB Binding C Cell Cells Cloning Competitive Cross-Linking Dimerization Endothelial Expression Factor Factors Fibrinolytic Gene Growth Heparin Human Humans Inbred Kinase Kinases Ligands Lymphokines Mice Mitogens Molecular Plastics Proliferation Protein Protein-Tyrosine Proteins Proto-Oncogene Reagents Receptor Receptor-1 Receptors Research Solubility Tyrosine Vascular antagonists cells drug effects genetics inhibitors isolation metabolism pharmacology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Human anti-animal antibody interferences in immunological assays
L. J. Kricka Clin.Chem. 45(7):942-956 (1999)
to Animals Antibodies Antibody Body False Fluids Human Humans Immunoassay Laboratories Mice Monoclonal Negative Population Positive RANGE Reactions Specificity analysis immunology methods pathology response standards therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
M. J. Karkkainen, R. E. Ferrell, E. C. Lawrence, M. A. Kimak, K. L. Levinson, M. A. McTigue, K. Alitalo, and D. N. Finegold Nat.Genet. 25(2):153-159 (2000)
to 5 Activation Alleles Animals C Cell Chemistry Chromosomes Data Dominant Endothelial Enzyme Factor Factors Female Fusion Genes Growth Half-Life Human Humans Infant Kinase Kinases Laboratories Line Lymphedema Male Mice Missense Models Molecular Mutation Newborn Pair Pedigree Phosphorylation Protein Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Sequence Signal Stability Structure Surface Transcriptional Transduction Tyrosine Vascular congenital drug effects genetics metabolism pharmacology protein secondary by kanefendt on Feb 5, 2010, 11:28 AM
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Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
A. M. Petit, J. Rak, M. C. Hung, P. Rockwell, N. Goldstein, B. Fendly, and R. S. Kerbel Am.J.Pathol. 151(6):1523-1530 (1997)
to A Adenocarcinoma Animals Antibodies Breast Carcinoma Cell Cells Cultured Dose-Response Down-Regulation Drug Endothelial Epidermal Expression Factor Factors Gene Growth Human Humans Immunoenzyme Lymphokines Mice Monoclonal Neoplasm Neoplasms Neoplastic Neovascularization Neutralization Nude Oncogenes Pathologic Proliferation Receptor Regulation Relationship Research Signal Squamous Survival Techniques Tests Transduction Transplantation Tumor Tyrosine Vascular blood cells drug effects erbB-2 immunology metabolism pathology pharmacology physiology protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
J. A. Forsythe, B. H. Jiang, N. V. Iyer, F. Agani, S. W. Leung, R. D. Koos, and G. L. Semenza Mol.Cell Biol. 16(9):4604-4613 (1996)
to (Genetics) 1 40 A Acid Alignment Animals Base Binding Carcinoma Cell Cells Chemistry Cultured DNA-Binding Data Endothelial Expression Factor Factors Fusion Gene Genes Genetic Growth Hepatocellular Homology Human Humans Hypoxia Hypoxia-Inducible Liver Lymphokines Mice Molecular Neoplasms Nuclear Nucleic Promoter Proteins Rats Recombinant Regions Regulation Reporter Research Sequence Simian Subunit Transcription Transfection Tumor Vascular alpha biosynthesis cells genetics metabolism pathology physiology protein response virus by kanefendt on Feb 5, 2010, 11:28 AM
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Different efficacy of various blocking reagents to eliminate interferences by human antimouse antibodies with a two-site immunoassay
J. Reinsberg Clin.Biochem. 29(2):145-148 (1996)
to Analysis Animals Antibodies Antigen Blocking Blood CA-125 Chemical Evaluation False Heterophile Human Humans Immunoassay Indicators Mice Positive RANGE Reactions Reagents Studies Topic and as blood methods by kanefendt on Feb 5, 2010, 11:28 AM
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