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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Receptor tyrosine kinases: mechanisms of activation and signaling
S. R. Hubbard, and W. T. Miller Curr.Opin.Cell Biol. 19(2):117-123 (2007)
to Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of lymphatic vascular development
T. Makinen, C. Norrmen, and T. V. Petrova Cell Mol.Life Sci. 64(15):1915-1929 (2007)
to A Angiopoietins Animals Biological Cells Cultured Endothelial Factor Growth Human Humans Inflammation Lymphangiogenesis Lymphatic Lymphedema Models Proteins Receptors Research Substances TIE Transport Vascular Vesicular Vessels analysis cells cytology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Appropriate calibration curve fitting in ligand binding assays
J. W. Findlay, and R. F. Dillard AAPS.J. 9(2):E260-E267 (2007)
to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
T. Force, D. S. Krause, and R. A. van Etten Nat.Rev.Cancer 7(5):332-344 (2007)
to & Adaptor Antibodies Benzenesulfonates Biological Delivery Diseases Drug Enzyme Heart Human Humans Indoles Inhibitors Kinase Kinases Models Monoclonal Mutation Neoplasms Protein Protein-Tyrosine Proteins Proto-Oncogene Pyridines Pyrroles Quinazolines Research Signal Systems Transducing Tyrosine adverse antagonists c-abl cells chemically development drug effects growth induced inhibitors physiology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Fit-for-purpose method development and validation for successful biomarker measurement
J. W. Lee, V. Devanarayan, Y. C. Barrett, R. Weiner, J. Allinson, S. Fountain, S. Keller, I. Weinryb, M. Green, L. Duan, J. A. Rogers, R. Millham, P. J. O'Brien, J. Sailstad, M. Khan, C. Ray, and J. A. Wagner Pharm.Res. 23(2):312-328 (2006)
to Approval Biological Calibration Chemistry Control Data Design Drug Interpretation Markers Models Quality Reproducibility Research Results Statistical Terminology Topic analysis as of by kanefendt on Feb 5, 2010, 11:28 AM
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Notch signaling in the regulation of tumor angiogenesis
A. O. Rehman, and C. Y. Wang Trends Cell Biol. 16(6):293-300 (2006)
to & Agents Angiogenesis Animals Binding Biological Blood Carcinogens Cells Endothelial Genes Humans Inducing Inhibitors Laboratories Ligands Models Neoplasms Neovascularization Notch Pathologic Receptors Signal Suppressor Transduction Tumor Vessels blood cells development growth metabolism physiology supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Possible molecular mechanisms involved in the toxicity of angiogenesis inhibition
H. M. Verheul, and H. M. Pinedo Nat.Rev.Cancer 7(6):475-485 (2007)
to & A Administration Agents Angiogenesis Antineoplastic Biological Blood Clinical Coagulation Drug Endothelial Factor Function Growth Humans Hypertension Inhibitors Left Models Neoplasm Platelets Research Resistance Schedule Signal Thrombosis Topic Transduction Trials Vascular Ventricular administration adverse antagonists as chemically dosage drug effects etiology induced inhibitors physiology toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap
F. T. Wu, M. O. Stefanini, Gabhann F. Mac, and A. S. Popel PLoS.One. 4(4):e5108 (2009)
to A Binding Biological Biology Capillaries Dimerization Endothelial Factor Growth Human Humans Ligands Lymphatic Models Muscle Plasma Receptor-1 Research Skeletal States Systems Tyrosine United Vascular Vessels metabolism physiology protein therapy ultrastructure by kanefendt on Feb 5, 2010, 11:28 AM
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Association of vascular endothelial growth factor and vascular endothelial growth factor receptor-2 genetic polymorphisms with outcome in a trial of paclitaxel compared with paclitaxel plus bevacizumab in advanced breast cancer: ECOG 2100
B. P. Schneider, M. Wang, M. Radovich, G. W. Sledge, S. Badve, A. Thor, D. A. Flockhart, B. Hancock, N. Davidson, J. Gralow, M. Dickler, E. A. Perez, M. Cobleigh, T. Shenkier, S. Edgerton, and K. D. Miller J.Clin.Oncol. 26(28):4672-4678 (2008)
to & A Antibodies Antineoplastic Breast Chemotherapy Combined Dna Endothelial Factor Female Genotype Growth Haplotypes Hazards Humans Hypertension Models Monoclonal Neoplasms Nonparametric Nucleotide Paclitaxel Polymorphism Proportional Protocols Rate Receptor-2 Research Retrospective Single Statistics Studies Survival Vascular administration dosage drug genetics methods pathology therapeutic therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular biology and pathology of lymphangiogenesis
T. Karpanen, and K. Alitalo Annu.Rev.Pathol. (2008)
to Animal Animals Biological Biology Developmental Endothelial Endothelium Expression Factors Gene Growth Humans Laboratories Lymphangiogenesis Lymphatic Lymphedema Markers Mice Models Molecular Regulation Research System Vascular Vessels cytology genetics metabolism methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Evaluation of logistic and polynomial models for fitting sandwich-ELISA calibration curves
R. A. Herman, P. N. Scherer, and G. Shan J.Immunol.Methods 339(2):245-258 (2008)
to Assay Calibration Enzyme-Linked Immunosorbent Models Proteins RANGE Theoretical methods protein standards by kanefendt on Feb 5, 2010, 11:28 AM
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The hemostatic system as a regulator of angiogenesis
T. Browder, J. Folkman, and S. Pirie-Shepherd J.Biol.Chem. 275(3):1521-1524 (2000)
to Aggregation Animals Biological Blood Capillaries Fibrin Fibrinolysis Hemostasis Models Neovascularization Physiologic Platelet Platelets Research Vessels physiology by kanefendt on Feb 5, 2010, 11:28 AM
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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
M. J. Karkkainen, R. E. Ferrell, E. C. Lawrence, M. A. Kimak, K. L. Levinson, M. A. McTigue, K. Alitalo, and D. N. Finegold Nat.Genet. 25(2):153-159 (2000)
to 5 Activation Alleles Animals C Cell Chemistry Chromosomes Data Dominant Endothelial Enzyme Factor Factors Female Fusion Genes Growth Half-Life Human Humans Infant Kinase Kinases Laboratories Line Lymphedema Male Mice Missense Models Molecular Mutation Newborn Pair Pedigree Phosphorylation Protein Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Sequence Signal Stability Structure Surface Transcriptional Transduction Tyrosine Vascular congenital drug effects genetics metabolism pharmacology protein secondary by kanefendt on Feb 5, 2010, 11:28 AM
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Application of the four-parameter logistic model to bioassay: comparison with slope ratio and parallel line models
A. Volund Biometrics 34(3):357-365 (1978)
to Assay Biological Dose-Response Drug Immunoassay Models RANGE Relationship analysis methods response by kanefendt on Feb 5, 2010, 11:28 AM
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An assessment of the 4-6-20 rule for acceptance of analytical runs in bioavailability, bioequivalence, and pharmacokinetic studies
R. O. Kringle Pharm.Res. 11(4):556-560 (1994)
to Analysis Availability Biological Control Design Equivalency Models Multivariate Pharmacokinetics Quality Research Statistical Therapeutic methods by kanefendt on Feb 5, 2010, 11:28 AM
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Receptor protein-tyrosine kinases and their signal transduction pathways
Geer P. van der, T. Hunter, and R. A. Lindberg Annu.Rev.Cell Biol. (1994)
to Acid Alignment Amino Animals Biological Conformation Data Factor Family Growth Homology Humans Kinase Kinases Laboratories Models Molecular Multigene Phosphorylation Post-Translational Processing Protein Protein-Tyrosine Receptor Receptors Sequence Signal Substances Transduction classification genetics physiology by kanefendt on Feb 5, 2010, 11:28 AM
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The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
G. Oliver, and M. Detmar Genes Dev. 16(7):773-783 (2002)
to Animals Biological Cytoplasm Diseases Factors Fluorescence Homeodomain Humans Lymphatic Mice Microscopy Models Proteins Research Suppressor System Time Tumor diagnosis embryology genetics metabolism physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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