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Monoclonal antibodies against epidermal growth factor receptor in advanced colorectal carcinoma: clinical efficacy and markers of sensitivity
E. Carcereny, and J. Maurel Rev.Recent Clin.Trials 1(2):113-118 (2006)
to & Animals Antibodies Biomarkers Carcinoma Colorectal Drug Epidermal Europe Factor Factors Growth Humans Immunologic Ligands Medical Monoclonal Mutation Neoplasm Neoplasms Oncology Pharmacological Phosphorylation Prognosis Receptor Resistance Tyrosine antagonists genetics inhibitors pharmacology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells
N. Rahimi, T. E. Golde, and R. D. Meyer Cancer Res. 69(6):2607-2614 (2009)
to Amyloid B-Cell C Cell Cells Cytoplasm Diffuse Endothelial Factor Growth Humans Hypertension Kinase Large Ligands Lymphoma Membrane Necrosis Phosphorylation Precursor Protein Receptor-1 Research Secretases Signal Structure Tertiary Transduction Tyrosine Vascular biosynthesis cells enzymology metabolism pathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
R. Kumar, M. C. Crouthamel, D. H. Rominger, R. R. Gontarek, P. J. Tummino, R. A. Levin, and A. G. King Br.J.Cancer 101(10):1717-1723 (2009)
to & 3 50 Angiogenesis Benzenesulfonates Bone Cell Cells Concentration Diseases Endothelial Factor Growth Hematologic Hematopoietic Human Humans Indoles Inhibitors Inhibitory Kinase Line Marrow Myelopoiesis Phosphorylation Platelet-Derived Protein Proteins Proto-Oncogene Pyridines Pyrimidines Pyrroles Receptors Research Specificity Stem Substrate Sulfonamides Tumor Tyrosine Vascular antagonists c-kit chemically drug effects enzymology fms-Like induced inhibitors methods pharmacology protein by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF receptor protein-tyrosine kinases: structure and regulation
R. Jr Roskoski Biochem.Biophys.Res.Commun. 375(3):287-291 (2008)
to Animals Chemistry Conformation Endothelial Factor Growth Human Humans Kinase Kinases Mice Phosphorylation Protein Protein-Tyrosine Receptor Receptor-1 Receptors Research Tyrosine Vascular blood classification metabolism by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
S. Swendeman, K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel Circ.Res. 103(9):916-918 (2008)
to A ADAM Amyloid Animals Cells Cercopithecus Cos Endothelial Extracellular Factor Factor-alpha Factors Fibroblasts Fusion Growth Human Humans Kinases Knockout MAP Membrane Mice Necrosis Neuropilin-1 Phosphorylation Precursor Protein Proteins Receptor-2 Recombinant Research Secretases Signal Signal-Regulated Swine Time Transduction Transfection Tumor Vascular aethiops cells deficiency enzymology genetics metabolism protein surgery by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells
H. M. Lee, H. J. Kim, K. J. Won, W. S. Choi, S. H. Park, H. Song, P. J. Park, T. K. Park, C. K. Lee, and B. Kim J.Vasc.Res. 45(3):259-268 (2008)
to & Adhesion Animals Aorta Cell Chemistry Cultured Dose-Response Drug Growth Hypertension Inbred Male Molecule-1 Movement Muscle Myocytes Phosphorylation Proliferation Rats Relationship Research SHR Signal Smooth Solubility Sprague-Dawley Transduction Tyrosine Vascular WKY administration cells cytology development dosage drug effects growth methods pathology pharmacology physiopathology response by kanefendt on Feb 5, 2010, 11:28 AM
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Proteolytic processing regulates receptor specificity and activity of VEGF-C
V. Joukov, T. Sorsa, V. Kumar, M. Jeltsch, L. Claesson-Welsh, Y. Cao, O. Saksela, N. Kalkkinen, and K. Alitalo EMBO J. 16(13):3898-3911 (1997)
to Acid Amino Animals Antibodies C Cells Cos Cultured Data Dimerization Disulfides Endopeptidases Endothelial Endothelium Factor Factors Growth Humans Kinase Kinases Laboratories Molecular Phosphorylation Post-Translational Processing Protein Protein-Tyrosine Rabbits Receptor Receptors Research Sequence Tumor Tyrosine Vascular biosynthesis cells genetics metabolism secretion by kanefendt on Feb 5, 2010, 11:28 AM
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Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
M. J. Karkkainen, R. E. Ferrell, E. C. Lawrence, M. A. Kimak, K. L. Levinson, M. A. McTigue, K. Alitalo, and D. N. Finegold Nat.Genet. 25(2):153-159 (2000)
to 5 Activation Alleles Animals C Cell Chemistry Chromosomes Data Dominant Endothelial Enzyme Factor Factors Female Fusion Genes Growth Half-Life Human Humans Infant Kinase Kinases Laboratories Line Lymphedema Male Mice Missense Models Molecular Mutation Newborn Pair Pedigree Phosphorylation Protein Protein-Tyrosine Proteins Receptor Receptor-3 Receptors Recombinant Research Sequence Signal Stability Structure Surface Transcriptional Transduction Tyrosine Vascular congenital drug effects genetics metabolism pharmacology protein secondary by kanefendt on Feb 5, 2010, 11:28 AM
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Receptor protein-tyrosine kinases and their signal transduction pathways
Geer P. van der, T. Hunter, and R. A. Lindberg Annu.Rev.Cell Biol. (1994)
to Acid Alignment Amino Animals Biological Conformation Data Factor Family Growth Homology Humans Kinase Kinases Laboratories Models Molecular Multigene Phosphorylation Post-Translational Processing Protein Protein-Tyrosine Receptor Receptors Sequence Signal Substances Transduction classification genetics physiology by kanefendt on Feb 5, 2010, 11:28 AM
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Overview of monoclonal antibodies and small molecules targeting the epidermal growth factor receptor pathway in colorectal cancer
L. C. Snyder, I. Astsaturov, and L. M. Weiner Clin.Colorectal Cancer (2005)
to & Administration Amplification Antibodies Approval Binding Colorectal Drug Epidermal Exanthema Factor Food Gene Growth Humans IgG Ligands Medical Molecular Monoclonal Neoplasms Oncology Phosphorylation Prognosis Receptor Receptors Signal Sites States Transduction Tyrosine United Weight and antagonists biosynthesis cells chemically drug induced inhibitors pharmacology physiology physiopathology response therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model
F. R. Luo, Z. Yang, H. Dong, A. Camuso, K. McGlinchey, K. Fager, C. Flefleh, D. Kan, I. Inigo, S. Castaneda, T. W. Wong, R. A. Kramer, R. Wild, and F. Y. Lee Clin.Cancer Res. 11(15):5558-5565 (2005)
to Agents Animals Antibodies Antigen Antineoplastic Antitumor Assay Assays Biological Carcinoma Cell Chemistry Colonic Enzyme-Linked Epidermal Factor Factors Female G Growth Human Humans Immunoglobulin Immunohistochemistry Immunosorbent Ki-67 Kinase Line MAP Markers Mice Model Monoclonal Neoplasm Neoplasms Nude Pharmacokinetics Phosphorylation Receptor Research Signaling System Time Transplantation Tumor Tyrosine Xenograft analysis biosynthesis drug metabolism methods pathology pharmacology protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Ligand-induced vascular endothelial growth factor receptor-3 VEGFR-3 heterodimerization with VEGFR-2 in primary lymphatic endothelial cells regulates tyrosine phosphorylation sites
J. Dixelius, T. Makinen, M. Wirzenius, M. J. Karkkainen, C. Wernstedt, K. Alitalo, and L. Claesson-Welsh J.Biol.Chem. 278(42):40973-40979 (2003)
to Animals Binding Blood Cell Cells Chemistry Dimerization Electrophoresis Endothelial Endothelium Factor Factors Gel Growth Humans Immunoblotting Ligands Line Lymphatic Mutation Neovascularization Pathologic Peptides Phosphorylation Polyacrylamide Protein Receptor-2 Receptor-3 Research Signal Sites Structure Swine Tertiary Transduction Transfection Tyrosine Up-Regulation Vascular Vessels blood cells genetics metabolism pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
K. Spiekermann, K. Bagrintseva, R. Schwab, K. Schmieja, and W. Hiddemann Clin.Cancer Res. 9(6):2140-2150 (2003)
to 3 Acid Activation Acute Amino Cell DNA-Binding Data Enzyme Factor Human Humans Indoles Kinase Kinases Leukemia Milk Mitogen-Activated Molecular Mutation Myeloid Neoplastic Phenotype Phosphorylation Protein Protein-Tyrosine Proteins Proto-Oncogene Receptor Research STAT3 STAT5 Sequence Trans-Activators Transcription Transformation Tyrosine cells fms-Like metabolism pathology pharmacology physiology protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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