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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Receptor tyrosine kinases: mechanisms of activation and signaling
S. R. Hubbard, and W. T. Miller Curr.Opin.Cell Biol. 19(2):117-123 (2007)
to Activation Animals Binding Biological Coenzymes Conformation Cross-Talk Enzyme Humans Kinase Kinases Ligands Models Protein Protein-Tyrosine Receptor Research Signal Transduction Tyrosine metabolism pharmacology by kanefendt on Feb 5, 2010, 11:28 AM
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Where is VEGF in the body? A meta-analysis of VEGF distribution in cancer
C. Kut, Gabhann F. Mac, and A. S. Popel Br.J.Cancer 97(7):978-985 (2007)
to A Assay Distribution Endothelial Enzyme-Linked Factor Growth Human Humans Immunosorbent Neoplasms Pharmacokinetics Prognosis Research Tissue Vascular blood cells diagnosis metabolism pathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of lymphatic vascular development
T. Makinen, C. Norrmen, and T. V. Petrova Cell Mol.Life Sci. 64(15):1915-1929 (2007)
to A Angiopoietins Animals Biological Cells Cultured Endothelial Factor Growth Human Humans Inflammation Lymphangiogenesis Lymphatic Lymphedema Models Proteins Receptors Research Substances TIE Transport Vascular Vesicular Vessels analysis cells cytology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate biomarkers in evaluating response to anti-angiogenic agents: focus on sunitinib
S. E. Deprimo, and C. Bello Ann.Oncol (2007)
to Angiogenesis Biological Cells Endothelial Growth Humans Indoles Inhibitors Laboratories Markers Neoplasms Neovascularization Pathologic Proteins Pyrroles Research Tumor blood cells diagnosis drug effects metabolism methods pathology pharmacology protein response supply therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Surrogate predictive biomarkers for response to anti-EGFR agents: state of the art and challenges
F. Cappuzzo, L. Toschi, G. Finocchiaro, C. Ligorio, and A. Santoro Int.J.Biol.Markers 22(1 Suppl 4):S10-S23 (2007)
to & Antibodies Biological Carcinoma Dosage Drug Epidermal Factor Gene Growth Human Humans Immunohistochemistry Inhibitors Kinase Kinases Lung Markers Monoclonal Mutation Neoplasm Neoplasms Non-Small-Cell Phosphoproteins Predictive Protein Protein-Tyrosine Proteins Proto-Oncogene Quinazolines Receptor Resistance Tests Tyrosine Value analysis antagonists c-akt drug effects erbB-2 erbB-3 genetics identify inhibitors of protein response therapeutic therapy use by kanefendt and 1 other user on Feb 5, 2010, 11:28 AM
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Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
Samuel Deprimo, Carlo Bello, John Smeraglia, Charles Baum, Dominic Spinella, Brian Rini, M. Dror Michaelson, and Robert Motzer Journal of Translational Medicine 5(1):32 (2007)
to Carcinoma Disease Placenta Progression Proteins Tyrosine analysis protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Appropriate calibration curve fitting in ligand binding assays
J. W. Findlay, and R. F. Dillard AAPS.J. 9(2):E260-E267 (2007)
to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
T. Force, D. S. Krause, and R. A. van Etten Nat.Rev.Cancer 7(5):332-344 (2007)
to & Adaptor Antibodies Benzenesulfonates Biological Delivery Diseases Drug Enzyme Heart Human Humans Indoles Inhibitors Kinase Kinases Models Monoclonal Mutation Neoplasms Protein Protein-Tyrosine Proteins Proto-Oncogene Pyridines Pyrroles Quinazolines Research Signal Systems Transducing Tyrosine adverse antagonists c-abl cells chemically development drug effects growth induced inhibitors physiology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. M. Ebos, C. R. Lee, J. G. Christensen, A. J. Mutsaers, and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A 104(43):17069-17074 (2007)
to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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The clinical toxicity profile of vascular endothelial growth factor VEGF and vascular endothelial growth factor receptor VEGFR targeting angiogenesis inhibitors; a review
F. A. Eskens, and J. Verweij Eur.J.Cancer 42(18):3127-3139 (2006)
to & A Angiogenesis Antibodies Endothelial Factor Growth Humans Inhibitors Kinase Kinases Medical Monoclonal Neoplasms Neovascularization Oncology Pathologic Protein Protein-Tyrosine Receptors Tyrosine Vascular adverse antagonists blood control drug effects inhibitors prevention protein supply therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment
A. Gampel, L. Moss, M. C. Jones, V. Brunton, J. C. Norman, and H. Mellor Blood 108(8):2624-2631 (2006)
to A Active Adult Biological Blood Cell Cells Compartmentation Cultured Endosomes Endothelial Factor GTP-Binding Growth Humans Kinases Laboratories Lysosomes Membrane Plasma Proteins Receptor-2 Recombinant Research Transport Tyrosine Vascular Vessels blood cells cytology drug effects metabolism pharmacology protein rab4 response src-Family by kanefendt on Feb 5, 2010, 11:28 AM
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Tyrosine kinase inhibitors of vascular endothelial growth factor receptors in clinical trials: current status and future directions
A. Morabito, Maio E. De, Maio M. Di, N. Normanno, and F. Perrone Oncologist. 11(7):753-764 (2006)
to & A Angiogenesis Clinical Endothelial Factor Growth Human Humans Inhibitors Kinase Kinases Lung Neoplasms Piperidines Protein Protein-Tyrosine Proteins Quinazolines Receptors Research Safety Topic Trials Tyrosine Vascular antagonists as drug inhibitors metabolism protein therapeutic therapy use by kanefendt on Feb 5, 2010, 11:28 AM
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Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
I. Shiojima, and K. Walsh Genes Dev. 20(24):3347-3365 (2006)
to & Adaptation Animals Cardiac Cardiomegaly Cell Contraction Differentiation Diseases Failure Growth Heart Humans Hypertension Myocardial Myocytes Neovascularization Physiologic Physiological Proteins Proto-Oncogene Signal Sports Transduction c-akt cytology development embryology genetics growth metabolism pathology physiology physiopathology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Differential roles of vascular endothelial growth factor receptor-1 and receptor-2 in angiogenesis
M. Shibuya J Biochem.Mol.Biol. 39(5):469-478 (2006)
to A Animals Atherosclerosis Cells Chemistry Development Dna Embryonic Endothelial Factor Female Growth Human Humans Inflammation Japan Metastasis Mice Neoplasm Neoplasms Neovascularization Pathologic Physiologic Pre-Eclampsia Pregnancy Proteins Receptor-1 Receptor-2 Research Signal Transduction Tyrosine Vascular Viral blood cells genetics metabolism physiology physiopathology protein response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis
A. Y. Debrah, S. Mand, S. Specht, Y. Marfo-Debrekyei, L. Batsa, K. Pfarr, J. Larbi, B. Lawson, M. Taylor, O. Adjei, and A. Hoerauf PLoS.Pathog. 2(9):e92 (2006)
to & Adult Aged Animals C Data Doxycycline Elephantiasis Endothelial Factor Female Filarial Filaricides Growth Humans Hydrocele Intercellular Lymphatic Lymphedema Male Microfilaria Middle Molecular Outcome Parasitemia Peptides Plasma Proteins Receptor-3 Research Sequence Signaling System Testicular Testis Treatment Vascular Vessels Wolbachia and antagonists blood drug effects immunology inhibitors isolation parasitology pathology physiology protein purification therapeutic therapy ultrasonography use by kanefendt on Feb 5, 2010, 11:28 AM
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