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Appropriate calibration curve fitting in ligand binding assays
J. W. Findlay, and R. F. Dillard AAPS.J. 9(2):E260-E267 (2007)
to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. M. Ebos, C. R. Lee, J. G. Christensen, A. J. Mutsaers, and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A 104(43):17069-17074 (2007)
to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. A. Eskens, N. Steeghs, J. Verweij, J. L. Bloem, O. Christensen, Doorn L. van, J. Ouwerkerk, M. J. Jonge, J. W. Nortier, J. Kraetzschmar, P. Rajagopalan, and H. Gelderblom J.Clin.Oncol. 27(25):4169-4176 (2009)
to & A Administration Adolescent Adult Aged Angiogenesis Biological Contrast Dose Dose-Response Drug Endothelial Factor Factors Fatigue Female Growth Human Humans Hypertension Imaging Inhibitors Kinase Magnetic Male Markers Maximum Media Medical Metastasis Middle Neoplasm Neoplasms Oncology Oral Outcome Pharmacokinetics Plasma Platelet-Derived Protein Proteins Proto-Oncogene Pyridazines Pyridines Receptor Receptor-2 Receptor-3 Relationship Research Resonance Safety Schedule Time Tolerated Treatment Tumor Tyrosine Vascular Young administration adverse antagonists beta blood c-kit diagnostic dosage drug effects enzymology inhibitors methods pathology protein response supply therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Soluble form of vascular cell adhesion molecule 1 induces migration and proliferation of vascular smooth muscle cells
H. M. Lee, H. J. Kim, K. J. Won, W. S. Choi, S. H. Park, H. Song, P. J. Park, T. K. Park, C. K. Lee, and B. Kim J.Vasc.Res. 45(3):259-268 (2008)
to & Adhesion Animals Aorta Cell Chemistry Cultured Dose-Response Drug Growth Hypertension Inbred Male Molecule-1 Movement Muscle Myocytes Phosphorylation Proliferation Rats Relationship Research SHR Signal Smooth Solubility Sprague-Dawley Transduction Tyrosine Vascular WKY administration cells cytology development dosage drug effects growth methods pathology pharmacology physiopathology response by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
J. D. Hood, C. J. Meininger, M. Ziche, and H. J. Granger Am.J.Physiol 274(3 Pt 2):H1054-H1058 (1998)
to A Calcium Capillaries Cells Cultured Dose-Response Drug Endothelial Endothelium Enzymologic Expression Factor Factors Gene Growth Human Humans Lymphokines Microcirculation Nitric Oxide Regulation Relationship Research Synthase Time Up-Regulation Vascular cells drug effects metabolism pharmacology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Optimizing the use of biomarkers, surrogate endpoints, and clinical endpoints for more efficient drug development
W. A. Colburn J.Clin.Pharmacol. 40(12 Pt 2):1419-1427 (2000)
to Biological Design Dose-Response Drug Factors Forecasting Humans Laboratories Markers Pharmacokinetics Relationship Reproducibility Results Time analysis drug of therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Neutralizing antibodies against epidermal growth factor and ErbB-2/neu receptor tyrosine kinases down-regulate vascular endothelial growth factor production by tumor cells in vitro and in vivo: angiogenic implications for signal transduction therapy of solid tumors
A. M. Petit, J. Rak, M. C. Hung, P. Rockwell, N. Goldstein, B. Fendly, and R. S. Kerbel Am.J.Pathol. 151(6):1523-1530 (1997)
to A Adenocarcinoma Animals Antibodies Breast Carcinoma Cell Cells Cultured Dose-Response Down-Regulation Drug Endothelial Epidermal Expression Factor Factors Gene Growth Human Humans Immunoenzyme Lymphokines Mice Monoclonal Neoplasm Neoplasms Neoplastic Neovascularization Neutralization Nude Oncogenes Pathologic Proliferation Receptor Regulation Relationship Research Signal Squamous Survival Techniques Tests Transduction Transplantation Tumor Tyrosine Vascular blood cells drug effects erbB-2 immunology metabolism pathology pharmacology physiology protein therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Application of the four-parameter logistic model to bioassay: comparison with slope ratio and parallel line models
A. Volund Biometrics 34(3):357-365 (1978)
to Assay Biological Dose-Response Drug Immunoassay Models RANGE Relationship analysis methods response by kanefendt on Feb 5, 2010, 11:28 AM
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Genetic heterogeneity of the vasculogenic phenotype parallels angiogenesis; Implications for cellular surrogate marker analysis of antiangiogenesis
Y. Shaked, F. Bertolini, S. Man, M. S. Rogers, D. Cervi, T. Foutz, K. Rawn, D. Voskas, D. J. Dumont, Y. Ben-David, J. Lawler, J. Henkin, J. Huber, D. J. Hicklin, R. J. D'Amato, and R. S. Kerbel Cancer Cell 7(1):101-111 (2005)
to A Angiogenesis Animals Antibodies Assay Biological Cell Cells Cytometry Dose-Response Drug Endothelial Factor Factors Fibroblast Flow Growth Humans Inbred Inhibitors Male Markers Mice Neovascularization Pathologic Phenotype Receptor Receptor-2 Relationship Research Stem Strains Survival TIE-2 Transgenic Vascular analysis blood cells drug effects genetics metabolism methods pharmacology physiology therapy by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A regulates the expression of VEGF-C in human retinal pigment epithelial cells
B. Zhao, A. Ma, J. Cai, and M. Boulton Br.J.Ophthalmol. 90(8):1052-1059 (2006)
to A C Cells Chain Choroidal Cultured Dose-Response Drug Endothelial Epithelial Epithelium Expression Eye Factor Gene Glucose Growth Human Humans Messenger Neovascularization Pigment Polymerase Proteins RNA Reaction Receptor-3 Recombinant Regulation Relationship Research Reverse Synergism Transcriptase Vascular analysis cells chemically cytology drug effects genetics induced metabolism methods of pharmacology protein secretion by kanefendt on Feb 5, 2010, 11:28 AM
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