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Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
N. Henke, R. Schmidt-Ullrich, R. Dechend, J. K. Park, F. Qadri, M. Wellner, M. Obst, V. Gross, R. Dietz, F. C. Luft, C. Scheidereit, and D. N. Muller Circ.Res. 101(3):268-276 (2007)
to & Adhesion Albuminuria Angiotensin Animals Atherosclerosis B Blood C57BL Cardiovascular Cell Cells Chain Chloride Cultured Dietary Diseases Endothelial Ester Expression Factor-alpha Fusion Gene Humans Hypertension I-kappa II III Inbred Inflammation Intercellular Kidney Methyl Mice Models Molecule-1 NF-kappa NG-Nitroarginine Necrosis Nephritis Nitric Organ Oxide Polymerase Pressure Proteins Reaction Receptor Recombinant Regulation Research Reverse Signal Sodium Specificity Synthase TIE-1 Transcriptase Transduction Transgenic Tumor Type Vascular antagonists biosynthesis blood cells complications control etiology genetics inhibitors metabolism physiology physiopathology prevention protein toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Key elements of bioanalytical method validation for macromolecules
M. Kelley, and B. DeSilva AAPS.J. 9(2):E156-E163 (2007)
to Antibodies Binding Chemistry Immunoassay Indicators Ligands Macromolecular Monoclonal Pharmaceutical Pharmacokinetics Preparations Reagents Reference Reproducibility Results Sensitivity Specificity Standards Substances analysis and metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Appropriate calibration curve fitting in ligand binding assays
J. W. Findlay, and R. F. Dillard AAPS.J. 9(2):E260-E267 (2007)
to & Algorithms Analytical Binding Calibration Chemistry Dose-Response Drug Ligands Models Pharmaceutical Pharmacokinetics Preparations Protein RANGE Relationship Reproducibility Research Results Sensitivity Specificity Statistical analysis and data metabolism methods numerical of response statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Multiple circulating proangiogenic factors induced by sunitinib malate are tumor-independent and correlate with antitumor efficacy
J. M. Ebos, C. R. Lee, J. G. Christensen, A. J. Mutsaers, and R. S. Kerbel Proc.Natl.Acad.Sci.U.S.A 104(43):17069-17074 (2007)
to & A Administration Agents Angiogenesis Animals Antineoplastic Antitumor Assays Blood Cell Dose-Response Drug Endothelial Factor Female Growth Humans Hypoxia Indoles Inducing Line Mice Model Neoplasms Organ Outcome Placenta Pregnancy Proteins Pyrroles RANGE Receptor-2 Relationship Research Schedule Scid Specificity Treatment Tumor Tyrosine Vascular Xenograft administration blood dosage drug effects metabolism pathology pharmacology protein response therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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Quantitative bioanalytical methods validation and implementation: best practices for chromatographic and ligand binding assays
C. T. Viswanathan, S. Bansal, B. Booth, A. J. DeStefano, M. J. Rose, J. Sailstad, V. P. Shah, J. P. Skelly, P. G. Swann, and R. Weiner Pharm.Res. 24(10):1962-1973 (2007)
to & Administration Animals Artifacts Assay Binding Biological Body Calibration Chemistry Chromatography Control Documentation Drug Fluids Food Government Guidelines Humans Macromolecular Pharmaceutical Quality Radioligand Reference Regulation Reproducibility Research Results Species Specificity Stability Standards States Substances Technology Topic United and as jurisprudence legislation methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Critical ligand binding reagent preparation/selection: when specificity depends on reagents
B. Rup, and D. O'Hara AAPS.J. 9(2):E148-E155 (2007)
to Antibodies Binding Chemistry Immunoassay Indicators Ligands Monoclonal Pharmaceutical Pharmacokinetics Preparations Reagents Reproducibility Research Results Safety Sensitivity Specificity and metabolism methods of standards by kanefendt on Feb 5, 2010, 11:28 AM
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Myelosuppression and kinase selectivity of multikinase angiogenesis inhibitors
R. Kumar, M. C. Crouthamel, D. H. Rominger, R. R. Gontarek, P. J. Tummino, R. A. Levin, and A. G. King Br.J.Cancer 101(10):1717-1723 (2009)
to & 3 50 Angiogenesis Benzenesulfonates Bone Cell Cells Concentration Diseases Endothelial Factor Growth Hematologic Hematopoietic Human Humans Indoles Inhibitors Inhibitory Kinase Line Marrow Myelopoiesis Phosphorylation Platelet-Derived Protein Proteins Proto-Oncogene Pyridines Pyrimidines Pyrroles Receptors Research Specificity Stem Substrate Sulfonamides Tumor Tyrosine Vascular antagonists c-kit chemically drug effects enzymology fms-Like induced inhibitors methods pharmacology protein by kanefendt on Feb 5, 2010, 11:28 AM
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VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors
T. V. Petrova, P. Bono, W. Holnthoner, J. Chesnes, B. Pytowski, H. Sihto, P. Laakkonen, P. Heikkila, H. Joensuu, and K. Alitalo Cancer Cell 13(6):554-556 (2008)
to Antibodies Antibody Blood Blotting Cell Cells Chain Chemistry Cytometry Endothelial Factor Flow Growth Humans Immunohistochemistry Line Lymphatic Messenger Neoplasms Northern Polymerase RNA Reaction Receptor-3 Reproducibility Results Reverse Separation Specificity Transcriptase Tumor Vascular Vessels Western analysis blood genetics immunology methods of pathology supply by kanefendt on Feb 5, 2010, 11:28 AM
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Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo?
W. Wynendaele, R. Derua, M. F. Hoylaerts, A. Pawinski, E. Waelkens, E. A. Bruijn, R. Paridaens, W. Merlevede, and A. T. van Oosterom Ann.Oncol. 10(8):965-971 (1999)
to A Adult Aged Assay Biological Endothelial Enzyme-Linked Factor Factors Female Growth Humans Immunosorbent Lymphokines Male Markers Middle Neoplasms Neovascularization Nonparametric Pathologic RANGE Reference Research Sensitivity Specificity Statistics Tumor Values Vascular analysis and blood diagnosis methods by kanefendt on Feb 5, 2010, 11:28 AM
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Release of the angiogenic cytokine vascular endothelial growth factor VEGF from platelets: significance for VEGF measurements and cancer biology
R. E. Banks, M. A. Forbes, S. E. Kinsey, A. Stanley, E. Ingham, C. Walters, and P. J. Selby Br.J Cancer 77(6):956-964 (1998)
to A Acid Adult Aged Assay Biological Blood Bone Cells Citrates Collection Edetic Endothelial Enzyme-Linked Factor Factors Female Growth Healing Heparin Humans Immunohistochemistry Immunosorbent Indicators Lymphokines Male Markers Marrow Megakaryocytes Middle Platelets Reagents Reference Research Sensitivity Specificity Specimen Values Vascular Wound and biosynthesis blood cells cytology methods physiology by kanefendt on Feb 5, 2010, 11:28 AM
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Interference in immunoassay
C. Selby Ann.Clin.Biochem. (1999)
to Animals Humans Immunoassay Indicators Reagents Sensitivity Specificity and methods by kanefendt on Feb 5, 2010, 11:28 AM
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Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective
J. W. Findlay, W. C. Smith, J. W. Lee, G. D. Nordblom, I. Das, B. S. DeSilva, M. N. Khan, and R. R. Bowsher J.Pharm.Biomed.Anal. 21(6):1249-1273 (2000)
to Algorithms Antibodies Calibration Control Disease Immunoassay Molecular Progression Quality Reproducibility Results Safety Sensitivity Specificity Weight analysis and metabolism methods of protein response standards by kanefendt on Feb 5, 2010, 11:28 AM
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Human anti-animal antibody interferences in immunological assays
L. J. Kricka Clin.Chem. 45(7):942-956 (1999)
to Animals Antibodies Antibody Body False Fluids Human Humans Immunoassay Laboratories Mice Monoclonal Negative Population Positive RANGE Reactions Specificity analysis immunology methods pathology response standards therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Method dependence of interpretation of immunoassay results
U. H. Stenman, H. Alfthan, and U. Turpeinen Scand.J.Clin.Lab Invest Suppl (1991)
to & Animals Antibodies Antigens Binding Hormones Humans Immunoassay Neoplasm Peptides Protein Sensitivity Specificity analysis and data methods numerical standards statistics by kanefendt on Feb 5, 2010, 11:28 AM
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Calibration is the key to immunoassay but the ideal calibrator is unattainable
J. T. Whicher Scand.J.Clin.Lab Invest Suppl (1991)
to Antibodies Antigens Blood Calibration Humans Immunoassay Peptides Proteins Reference Sensitivity Specificity Standards analysis and blood immunology pathology protein standards by kanefendt on Feb 5, 2010, 11:28 AM
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The effects of common matrices for assay standards on performance of ültra sensitive" immunometric assays for TSH. Report of a joint WHO/IFCC collaborative study
R. E. Gaines-Das, H. Brettschneider, and A. F. Bristow Ann.Biol.Clin.Paris 49(10):522-527 (1991)
to Calibration Humans Hyperthyroidism Hypothyroidism Immunoassay Laboratories RANGE Sensitivity Specificity Thyrotropin and blood methods response standards by kanefendt on Feb 5, 2010, 11:28 AM
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Method validation in the bioanalytical laboratory
A. R. Buick, M. V. Doig, S. C. Jeal, G. S. Land, and R. D. McDowall J.Pharm.Biomed.Anal. 8(8-12):629-637 (1990)
to Chemistry Drug Freezing Mass Pharmaceutical Reference Research Solubility Species Specificity Spectrometry Stability Standards Temperature instrumentation methods standards by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4, a novel class III receptor tyrosine kinase in chromosome 5q33-qter
O. Aprelikova, K. Pajusola, J. Partanen, E. Armstrong, R. Alitalo, S. K. Bailey, J. McMahon, J. Wasmuth, K. Huebner, and K. Alitalo Cancer Res. 52(3):746-748 (1992)
to 5 Acid Adult Amino Banding Blotting Cell Chain Chromosome Chromosomes Data Dna Homology Human Humans Kidney Kinase Kinases Leukemia Lung Messenger Molecular Northern Nucleic Organ Pair Placenta Polymerase Protein-Tyrosine RNA Reaction Receptors Research Sequence Specificity Surface Tyrosine analysis cells genetics by kanefendt on Feb 5, 2010, 11:28 AM
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FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines
K. Pajusola, O. Aprelikova, J. Korhonen, A. Kaipainen, L. Pertovaara, R. Alitalo, and K. Alitalo Cancer Res. 52(20):5738-5743 (1992)
to & Acid Amino Base Blood Cell Cells Chemistry Cloning Conformation Data Development Differentiation Distribution Dna Down-Regulation Embryonic Endothelial Epithelial Expression Factor Fetal Gene Growth Homology Human Humans Immunoglobulins Kinase Kinases Leukemia Line Lung Molecular Nucleic Protein Protein-Tyrosine Receptor-3 Receptors Research Sequence Species Specificity Surface Teratoma Tissue Tyrosine Vascular Vessels and blood cells genetics isolation pathology protein purification by kanefendt on Feb 5, 2010, 11:28 AM
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Bioanalytical method validation for macromolecules in support of pharmacokinetic studies
J. Smolec, B. DeSilva, W. Smith, R. Weiner, M. Kelly, B. Lee, M. Khan, R. Tacey, H. Hill, A. Celniker, V. Shah, R. Bowsher, A. Mire-Sluis, J. W. Findlay, M. Saltarelli, V. Quarmby, D. Lansky, R. Dillard, M. Ullmann, S. Keller, and H. T. Karnes Pharm.Res. 22(9):1425-1431 (2005)
to Analytical Binding Calibration Chemistry Laboratories Pharmacokinetics Reference Reproducibility Results Sensitivity Specificity Standards and methods of by kanefendt on Feb 5, 2010, 11:28 AM
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