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Phase I dose escalation study of telatinib, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor 2 and 3, platelet-derived growth factor receptor beta, and c-Kit, in patients with advanced or metastatic solid tumors
F. A. Eskens, N. Steeghs, J. Verweij, J. L. Bloem, O. Christensen, Doorn L. van, J. Ouwerkerk, M. J. Jonge, J. W. Nortier, J. Kraetzschmar, P. Rajagopalan, and H. Gelderblom J.Clin.Oncol. 27(25):4169-4176 (2009)
to & A Administration Adolescent Adult Aged Angiogenesis Biological Contrast Dose Dose-Response Drug Endothelial Factor Factors Fatigue Female Growth Human Humans Hypertension Imaging Inhibitors Kinase Magnetic Male Markers Maximum Media Medical Metastasis Middle Neoplasm Neoplasms Oncology Oral Outcome Pharmacokinetics Plasma Platelet-Derived Protein Proteins Proto-Oncogene Pyridazines Pyridines Receptor Receptor-2 Receptor-3 Relationship Research Resonance Safety Schedule Time Tolerated Treatment Tumor Tyrosine Vascular Young administration adverse antagonists beta blood c-kit diagnostic dosage drug effects enzymology inhibitors methods pathology protein response supply therapy toxicity use by kanefendt on Feb 5, 2010, 11:28 AM
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Cardiac toxicity of sunitinib and sorafenib in patients with metastatic renal cell carcinoma
M. Schmidinger, C. C. Zielinski, U. M. Vogl, A. Bojic, M. Bojic, C. Schukro, M. Ruhsam, M. Hejna, and H. Schmidinger J.Clin.Oncol. 26(32):5204-5212 (2008)
to 80 Aged Arteries Artery Benzenesulfonates Biological Carcinoma Cardiovascular Cell Coronary Disease Diseases Echocardiography Electrocardiography Estimate Factors Failure Female Heart Humans Hypertension Indoles Inhibitors Kaplan-Meiers Kidney Kinase Male Markers Metastasis Middle Neoplasm Neoplasms Outcome Prospective Protein Pyridines Pyrroles Renal Research Risk Studies Time Treatment Tyrosine adverse and blood chemically diagnosis drug effects enzymology induced methods mortality over pathology protein therapy toxicity by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling
S. Swendeman, K. Mendelson, G. Weskamp, K. Horiuchi, U. Deutsch, P. Scherle, A. Hooper, S. Rafii, and C. P. Blobel Circ.Res. 103(9):916-918 (2008)
to A ADAM Amyloid Animals Cells Cercopithecus Cos Endothelial Extracellular Factor Factor-alpha Factors Fibroblasts Fusion Growth Human Humans Kinases Knockout MAP Membrane Mice Necrosis Neuropilin-1 Phosphorylation Precursor Protein Proteins Receptor-2 Recombinant Research Secretases Signal Signal-Regulated Swine Time Transduction Transfection Tumor Vascular aethiops cells deficiency enzymology genetics metabolism protein surgery by kanefendt on Feb 5, 2010, 11:28 AM
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VEGF upregulates ecNOS message, protein, and NO production in human endothelial cells
J. D. Hood, C. J. Meininger, M. Ziche, and H. J. Granger Am.J.Physiol 274(3 Pt 2):H1054-H1058 (1998)
to A Calcium Capillaries Cells Cultured Dose-Response Drug Endothelial Endothelium Enzymologic Expression Factor Factors Gene Growth Human Humans Lymphokines Microcirculation Nitric Oxide Regulation Relationship Research Synthase Time Up-Regulation Vascular cells drug effects metabolism pharmacology physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Elevated levels of angiogenic cytokines in the plasma of cancer patients
E. Fuhrmann-Benzakein, M. N. Ma, L. Rubbia-Brandt, G. Mentha, D. Ruefenacht, A. P. Sappino, and M. S. Pepper Int.J Cancer 85(1):40-45 (2000)
to 2 A Adult Aged Cytokines Endothelial Factor Factor-alpha Factors Fibroblast Growth Hepatocyte Humans Lymphokines Middle Necrosis Neoplasms Neovascularization Pathologic Prospective Reference Research Studies Time Transforming Tumor Values Vascular beta blood cells metabolism pathology response supply therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Optimizing the use of biomarkers, surrogate endpoints, and clinical endpoints for more efficient drug development
W. A. Colburn J.Clin.Pharmacol. 40(12 Pt 2):1419-1427 (2000)
to Biological Design Dose-Response Drug Factors Forecasting Humans Laboratories Markers Pharmacokinetics Relationship Reproducibility Results Time analysis drug of therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Circulating endothelial cells as a marker of endothelial damage in allogeneic hematopoietic stem cell transplantation
A. Woywodt, J. Scheer, L. Hambach, S. Buchholz, A. Ganser, H. Haller, B. Hertenstein, and M. Haubitz Blood 103(9):3603-3605 (2004)
to Adult Aged Agents Antineoplastic Case-Control Cell Cells Conditioning Count Diseases Endothelial Endothelium Factors Female Hematopoietic Homologous Humans Male Microcirculation Middle Radiotherapy Stem Studies Time Transplantation Vascular adverse cells diagnosis effects etiology methods pathology by kanefendt on Feb 5, 2010, 11:28 AM
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Prediction of active drug plasma concentrations achieved in cancer patients by pharmacodynamic biomarkers identified from the geo human colon carcinoma xenograft model
F. R. Luo, Z. Yang, H. Dong, A. Camuso, K. McGlinchey, K. Fager, C. Flefleh, D. Kan, I. Inigo, S. Castaneda, T. W. Wong, R. A. Kramer, R. Wild, and F. Y. Lee Clin.Cancer Res. 11(15):5558-5565 (2005)
to Agents Animals Antibodies Antigen Antineoplastic Antitumor Assay Assays Biological Carcinoma Cell Chemistry Colonic Enzyme-Linked Epidermal Factor Factors Female G Growth Human Humans Immunoglobulin Immunohistochemistry Immunosorbent Ki-67 Kinase Line MAP Markers Mice Model Monoclonal Neoplasm Neoplasms Nude Pharmacokinetics Phosphorylation Receptor Research Signaling System Time Transplantation Tumor Tyrosine Xenograft analysis biosynthesis drug metabolism methods pathology pharmacology protein response therapy by kanefendt on Feb 5, 2010, 11:28 AM
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Determination of vascular endothelial growth factor VEGF in circulating blood: significance of VEGF in various leucocytes and platelets
K. Werther, I. J. Christensen, and H. J. Nielsen Scand.J.Clin.Lab Invest 62(5):343-350 (2002)
to 80 A Adult Aged Blood Chemistry Coagulation Colorectal Count Endothelial Factor Factors Female Growth Humans Immunomagnetic Intercellular Leukocytes Lymphocytes Lymphokines Male Middle Monocytes Neoplasms Peptides Plasma Platelet Platelets Proteins Research Separation Signaling Time Vascular Whole analysis and blood cells immunology methods over protein by kanefendt on Feb 5, 2010, 11:28 AM
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Prognostic impact of matched preoperative plasma and serum VEGF in patients with primary colorectal carcinoma
K. Werther, I. J. Christensen, and H. J. Nielsen Br.J.Cancer 86(3):417-423 (2002)
to 80 A Adult Aged Biological Carcinoma Colonic Colorectal Endothelial Factor Factors Female Growth Humans Lymphokines Male Markers Middle Neoplasm Neoplasms Plasma RANGE Rate Rectal Reference Research Staging Survival Time Tumor Values Vascular and blood mortality over pathology surgery by kanefendt on Feb 5, 2010, 11:28 AM
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The rediscovery of the lymphatic system: old and new insights into the development and biological function of the lymphatic vasculature
G. Oliver, and M. Detmar Genes Dev. 16(7):773-783 (2002)
to Animals Biological Cytoplasm Diseases Factors Fluorescence Homeodomain Humans Lymphatic Mice Microscopy Models Proteins Research Suppressor System Time Tumor diagnosis embryology genetics metabolism physiology protein by kanefendt on Feb 5, 2010, 11:28 AM
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Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling
Y. He, K. Kozaki, T. Karpanen, K. Koshikawa, S. Yla-Herttuala, T. Takahashi, and K. Alitalo J.Natl.Cancer Inst. 94(11):819-825 (2002)
to & Animals Antibodies Blotting C Cell Cells Cultured D Division Endothelial Expression Factor Factors Female Gene Growth Human Humans Kinase Kinases Laboratories Line Lung Lymph Lymphangiogenesis Lymphatic Metastasis Mice Neoplasm Neoplasms Neoplastic Nodes Protein-Tyrosine RNA Receptor Receptor-3 Receptors Regulation Research Scid Signal Time Transduction Transfection Transplantation Tumor Vascular Vessels Western antagonists blood cells control genetics immunology inhibitors metabolism methods pathology prevention protein secondary supply by kanefendt on Feb 5, 2010, 11:28 AM
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